Immunology 2 GN PDF

Immunology 2 Tutor: Ms P Lazarou Module: Biomedical Sciences GDC Learning Outcomes The aim of this subject is to apply to the practice of dental therapy and dental hygiene principles that derive from the biomedical, behavioural and materials sciences. To develop knowledge in the study of im...

Immunology 2 Tutor: Ms P Lazarou Module: Biomedical Sciences GDC Learning Outcomes The aim of this subject is to apply to the practice of dental therapy and dental hygiene principles that derive from the biomedical, behavioural and materials sciences. To develop knowledge in the study of immunology. GDC 1.1 Assessment Forma&ve Summa&ve Quiz Ques&ons incorporated in Biomedical Sciences Eassessment 4 Immunology 2 1) Read and complete task on the following article, pages 5-8 from Antibody-mediated vs cell-mediate immunity: An introduction to immunology and immunopathology Richard Warrington1*, Wade Watson2 , Harold L Kim3,4, Francesca Romana Antonetti5 2) Complete the self-assessment quiz on the antibody mediated and cell mediated immunity 5 Intended Learning outcomes: Immunology 2 Review antibody mediated and cell mediated immunity by reading appropriate resources and completing a self assessment quiz Define and recognise the variances between antibody mediated and cell mediated immunity Recognise and explain passive and active immunization 6 Antibody-mediated and cell-mediated immunity Consolidation of learning The Cellular Immune Response – YouTube https://www.youtube.com/watch?v=oUpcRfpEh3c ANTIGEN PROCESSING AND PRESENTATION – YouTube https://www.youtube.com/watch?v=Bgd1qxQ0Dh4&feature=emb_logo 7 8 Passive and active immunity Acquired (adaptive) immunity Passive Active immunity immunity Natural passive immunity : e.g Artificial passive immunity: Natural active immunity: Artificial active immunity: mother’s antibodies through Transferred therapeutically e.g. Antibodies developed in Antibodies developed in placenta/breast milk snake antitoxin, response to infection response to a vaccination Immunoglobulin – transplant Transfer of anAbody or of sensiAsed cells from an ProducAon of anAbodies against a speciLc agent aMer immune person to a non-immune person. exposure to the anAgen. -Short duraAon. Person at risk when immunity runs out. -SpeciLc anAbodies idenALed as foreign - Used when infecAon risk is high/own response not -Response is speciLc to a parAcular anAgen developed -Memory: anAgen is remembered 9 Immunisation Artificial active immunity: antibodies develop after immunisation/administration of vaccine. How does this happen?  Immunological memory  A specific immune reaction induced against a weakened/killed microorganism  Subsequent infections from same pathogen raises a stronger and faster defensive reaction  This reaction may come from antibodies and/or cells.  Antibodies attach to specific surface structures on antigen – activates the complement system (see immunology 1) 1 0 Vaccines and the immune response h9ps://www.youtube.com/watch?v=Atrx1P2EkiQ 1 1 References: An introducAon to immunology and immunopathology Richard Warrington1*, Wade Watson2 , Harold L Kim3,4, Francesca Romana AntoneR5 McMahon R., Sloan P. Essen%als of Pathology for Den%stry. London: Harcourt Publishers, 2000 Allergy. h9ps://www.immunology.org/public-informa&on/bitesized-immunology/ immune-dysfunc&on/allergy Report on autoimmune awareness: connect-immune-research-are-you-autoimmune- report.pdf (immunology.org) Garcia P. Juvenile Diabetes Research Foundation (JDRF) 2018 h9ps://www.immunology.org/sites/default/Xles/connect-immune-research-are-you- autoimmune-report.pdf 1 2 References cont… British Society for immunology: Immunodeficiency: https://www.immunology.org/policy-and-public-affairs/briefings-and-position- statements/immunodeficiency Autoimmune Diseases and Their Manifestations on Oral Cavity: Diagnosis and Clinical Management (hindawi.com) https://www.hindawi.com/journals/jir/2018/6061825/ [accessed 12/01/21]