HMS 2025 Plasmodium Lecture PDF
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Warwick Medical School
Samuel Dean
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Summary
This lecture covers the different species of Plasmodium that cause malaria, the pathology of the disease, the Plasmodium life cycle, the human host cells it affects, and the mechanisms of chloroquine resistance. The lecture also details the epidemiology and geographical distribution of malaria, including the different species and their prevalence. It also discusses the mechanisms behind resistance to chloroquine.
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Plasmodium andDiseases Neglected Tropic malaria Samuel Samuel Dean, Dean, Assistant AssociateProfessor Professor [email protected] Learning objectives By the end of t...
Plasmodium andDiseases Neglected Tropic malaria Samuel Samuel Dean, Dean, Assistant AssociateProfessor Professor [email protected] Learning objectives By the end of this session you will be able to: Understand that Malaria is caused by different species of plasmodium Understand that the pathology of malaria is linked to their immune evasion via sequestration Understand the plasmodium lifecycle (it is complex!) Understand which human host cells plasmodium colonise Understand how sickle cell anaemia gives rise to plasmodium resistance Understand how chloroquine kills parasites and how parasites have become resistant to chloroquine Malaria epidemiology 4 Plasmodium species cause human Malaria Plasmodium falciparum Causes most of the deaths 99.7% of African cases All Malaria cases by species 97% of all world-wide cases P. vivax Mixed cases 2% P. vivax 1% usually uncomplicated Causes 75% of cases in Americas ~50% of S. E. Asia cases 2% of all malaria cases P. ovale - usually uncomplicated
