Functional Experiment 2 Golden Points PDF

# Experiment pulmonary edema - Agents used for pulmonary edema: Normal saline and adrenaline - Lung coefficients =weight of lung/weight of body # Hyperkalemia experiment (HK) - Agent used for HK : 4%KCL - Agent prevented HK: CaCl2 - Typical change in ECG: sharp T wave p wave flate, QRS wave widenin...

# Experiment pulmonary edema - Agents used for pulmonary edema: Normal saline and adrenaline - Lung coefficients =weight of lung/weight of body # Hyperkalemia experiment (HK) - Agent used for HK : 4%KCL - Agent prevented HK: CaCl2 - Typical change in ECG: sharp T wave p wave flate, QRS wave widening, ST segment short, M 3 phase wave - 10% KCl leads to death of rabbit # Analgesic effects if diclofanic sodium - Intraperitonial injection of acetic acid can cause: abdominal pain(writhing) - Which agent can prevent abdominal pain (writhing) diclofenac sodium - Acetic acid is volatile # Experiment organophosphate poisoning - Agents lead to organophosphate poisoning: Organophosphate - Antidote for organophosphate poisoning: Atropine, pralidoxime - Mechanism of organophosphate: inhibition of AchE - Mechanism of action of atropine: block M receptor - Mechanism of pralidoxime: Activation of AchE - Muscrinic symptoms (DUMBBELSS) - Diarrhea - Urination - Miosis (constriction of pupil) - Bronchospasm - Bradycardia - Emesis - Lacrimation - Salivation - Sweating # Experiment basic action or effect of drug - Mechanism of procain :block nerve conduction of sensory impulses- pain - Procain toxicity :convulsions - Antidote for procain toxicity (convulsions) : diazepam - Injection site in rabit of procaine for muscle relaxation: notch between ischial tuberosity and greater trochanter - Injection site of procain in Rabit for systemic symptoms: IM into thigh muscle on the opposite side of local injection side # Experiment general principles: - Method to capture the Rabit: Neck and skin by right hand buttock by left hand - Method to kill the Rabit: pulmonary embolism - Method to kill mice: cervical dislocation # Effects of furosemide on amount of rabit urine - Effect of furosemide on amount of urine: increase - Mechanism of action of furosemide: inhibit sodium potassium 2 chloride # Mixed - Volume of distribution= given drug/plasma drug - Righting reflex disappear: sleeping state (hypnosis ( - Renal blood flow increase: dopamine - LD50 indicates: toxicity of drug - TI = LD50/ED50 - Drug of choice for absence seizure in child: ethosuximede - Carbon monoxide poisoning: Cherry Red - Carbon monoxide leads to which hypoxia in rabbit: anemia hypoxia - In hepatic encephalopathy ammonium chloride given in: duodenum - Antidote for hepatic encephalopathy: sodium glutamate - Pink foam sputum not seen in: acute right heart failure - Mechanism of heparin: stimulation to antithrombin 3 - Fastest absorption: intraperitoneal injection - Index for anesthesia: corneal reflex disappear and muscle relaxation - Osmotic diuretic: Furosemide - Blood hypoxia causes: carbon monoxide poisoning', anemia', nitrite - Nitrite poisoning antidote =methylene blue - Half life 0.693/