Feline Pathology PDF

Disease What does it look like Lesions Clinical signs Pathogenesis/causes Diagnosis Diabetes mellitus - diffuse tan colouring of the - glucosuria - presence of Amyloidosis...

Disease What does it look like Lesions Clinical signs Pathogenesis/causes Diagnosis Diabetes mellitus - diffuse tan colouring of the - glucosuria - presence of Amyloidosis - blood tests liver glucose in urine - systemic - Urine tests - Enlarged - bilirubinuria - presence of - Primary - Fructosamine test - Fat overtaken tubules bilirubin in the urine - Secondary - hypoalbuminemia - body - Familial doesnt have enough albumin - Localised - liver: diffuse fat (helps keep fluid from leaking - IAPP accumulation out of the blood vessels) - Ab - nuclei pushed to edge of - bilirubinemia - too much cell due to fat bilirubin in the blood Glucose toxicity accumulation - ascites - accumulation of - prolongued hyperglycaemia fluid in the peritoneal cavity - downregulation of glucose - fluid accumulation - causing abdominal swelling transporters on beta cell ascites membranes - damage to pancreas by - impared insulin secretion by digestive enzymes released beta cells + induction of which destroys the fat causing peripheral insulin resistance it to turn hard - glycogen accumulation in islet - triditis (inflammation of cells common duct connecting - cell dearth pancreas, liver + duodenum) - amyloid deposited in islets lipotoxicity - presistently high serum fatty - Congo red stain used acids suppress insiulin secretion by beta cells Disease What does it look like Lesions Clinical signs Pathogenesis/causes Diagnosis Feline infectious peritonitis - atrophy of kidney - ataxia - loss of full control of - mutated form of feline enteric - histopathology (if - Tan cortex with multifocal bodily movements coronavirus (FIP virus) pathognomonic lesions raised lesions - nystagmus - eyes move - effusive (wet form) vs non- present) - Lesions around blood involuntarily in a repetitive, effusive (dry form) - detection of intracellular FCoV rhythmic + uncontrolled - effusion is a high protein antigen (immunofluorescence vessels in kidney manner exudate or modified transudate or immunohistochemistry) - seizures - granulomatous inflammation - RT-PCR - incoordination localised in the lymph nodes, - dark orange thick exudate - intention tremors - tremors kindeys, uvea, meninges, - Multifocal hard nodules occuring during any voluntary ependyma + choroid plexus of - Inflamed capsule of liver movements the brain + spinal chord - hyperesthesia - increased - type 3 hypersensitivity - multifocal fibrinous sensitivity to stimuli, such as reaction with vasculitis touch sound, smell + sight peritonitis with - behaviour changes hepatomegaly + multifocal - Cranial nerve deficites round firm foci on the - Head tilt serosal surface of multiple - - cranial nerve deficits organs - - head tilt - plaques located on apex of heart - Fibrin inflamed capsule of liver - vasculitis necrosis - Macrophages