Endo Patho Test 2-3.pdf

Pathology Test Session Endocrinology:- MCQ’s:- 1.A 40 years old female suddenly developed excruciating headache and diplopia.The patient was refered to ER and CT scan showed a pituitary growth.Which one is responsible for his condition? A.Sheehan syndrome B.Pituitary apoplexy C.Prolactinoma D.S...

Pathology Test Session Endocrinology:- MCQ’s:- 1.A 40 years old female suddenly developed excruciating headache and diplopia.The patient was refered to ER and CT scan showed a pituitary growth.Which one is responsible for his condition? A.Sheehan syndrome B.Pituitary apoplexy C.Prolactinoma D.Somatotroph adenoma of pituitary 2.A child presents with umbilical hernia,short stature,protruded tongue,mental retardation.What is the most likely diagnosis? A.Cretinism B.Acromegaly C.Dwarfism D.This condition is secondary to hypothyroidism in mother during pregnancy E.Gigantism 3.A 65 years old male presents with bone pain,hypocalcemia,increased PTH and enlarged all 04 parathyroid glands.What is the most likely cause of enlargement of parathyroid glands? A.Chronic renal failure B.Primary hyperparathyroidism C.Parathyroid adenoma D.Parathyroid carcinoma E.Tertiary hyperparathyroidism 4.A 32 years old lady complains of nausea,vomiting,diarrhea and abdominal pain.O/E,blood pressure is 90/60mmHg with postural drop and generalised pigmentation.On CBC,Hb is 10g/dl,WBC 5000,platelet 150000,Na+ is 128,K+ is 6.What is the most likely diagnosis? A.Pheochromocytoma B.Bilateral adrenal cortical hyperplasia C.Exogenous glucocorticoid administration D.Addison’s disease E.Cushing disease 5.A 35 year old woman has noted that the ring on her hand is now tight,her shoe size is increased in the last year.She complains of joint pain,numbness and tingling sensations on her thumb and first two fingers of the right hand.What is your diagnosis? A.Growth hormone adenoma B.Pituitary adenoma C.Prolactinoma D.Acromegaly E.B12 deficiency 6.A 25 year old ill man has attacks of headache, nervousness, palpitations,sweating and apprehension.His BP is 170-80/110-20mmHg during these attacks.His examination shows black pigmented spots on the skin.What is your diagnosis? A.Addison’s disease B.Addisonian crisis C.Cushing syndrome D.Cushing disease E.Pheochromocytoma 7.A 42 year old lady who is a known case of rheumatoid arthritis and bronchial asthma seen in medical OPD with 06 months history of lethargy,weight gain and weakness.She has acne on her face.What is the most likely diagnosis? A.Cushing disease B.Cushing syndrome C.Pheochromocytoma D.Addison’s disease E.Exogenous glucocorticoid administration 8.What is the most common pituitary adenoma? A.Growth hormone adenoma B.Thyrotroph adenoma C.Pituitary adenoma D.Prolactinoma E.Anyone can be prevalent depending upon the patient’s condition 9.A 5 year old boy has developed the features that suggest the development of puberty over the past 06 months.O/E,the child has developed secondary sex characters like pubic hair and enlargement of penis.Which of the following morphological features is most likely to be seen in his adrenal glands? A.Cortical atrophy B.Cortical hyperplasia C.Cortical nodule D.Medullary atrophy E.Medullary hyperplasia F.Medullary nodule 10.A 69 year old male has progressively obtunded over the past week.He has an 80 pack year of smoking cigarettes.O/E,he is afebrile and normotensive.Lab findings show Serum Na+ levels are 115mmol/L,K+ levels are 4.5mmol/L,Cl ions are 80mmol/L and bicarbonate ions are 23mmol/L.The serum glucose is 80mg/dl,creatinine is 1.9mg/dl,urea nitrogen is 19mg/dl.A head CT scan shows no intracerebral hemorrhage.Which of the following neoplasm is most likely to be present in this man? A.Adrenohypophyseal adenoma B.Adrenocortical carcinoma C.Pheochromocytoma D.Small cell lung CA E.Mixed tumor of lung or renal cell CA 11.Which of the following hormone levels is normally secreted in sheehan syndrome? A.ADH B.PTH C.GH D.TRH E.TSH 12.A patient came with a history of regular iatrogenic glucocorticoid intake due to which he developed Cushing syndrome.What morphological change do you expect in the adrenal gland? A.Hyperplasia B.Nodule formation in the cortex C.Nodule formation in the medulla D.No change E.Atrophy 13.What happens in pituitary apoplexy? A.Hyperpituitarism B.Hypopituitarism C.No change in gland’s function..only morphology is altered D.Can be hyperactive or hypoactive gland E.None of the above 14.What is the most common cause of primary hyperaldosteronism? A.Idiopathic B.Conn syndrome C.Adrenal adenoma D.Adrenal CA E.Bilateral adrenal hyperplasia 15.Which test will differentiate between the ACTH- dependant and ACTH-independant causes of Cushing syndrome? A.Low dose dexamethasone suppression test B.High dose dexamethasone suppression test C.Plasma ACTH D.Serum cortisol E.24 hour urinary cortisol 16.Hypertension,hypokalemia and metabolic alkalosis are classical signs of: A.Addison’s disease B.Pheochromocytoma C.Cushing syndrome D.Diabetes mellitus leading to vascular malformations E.Hyperaldosteronism 17.Hypercalcemia may lead to which GIT problems? A.Mouth ulcers B.Peptic ulcers C.Appendicitis D.Pancreatitis E.A and C both F.B and D both 18.A type 2 diabetic male suddenly faint.His blood glucose level is 550mg/dl.What is the cause? A.Dehydration B.He forgot to take insulin C.Constipation D.Cardiac deterioration E.None 19.Mutation associated with papillary carcinoma: A.RAS B.tp53 C.RET proto-oncogene D.MAPK pathway activation E None 20.Gene mutation associated with Grave’s disease: A.HLA-DQ2 B.HLA-DQ8 C.HLA-DR3 D.HLA-DR4 E.None of the above 21.Digeorge syndrome is associated with which chromosome? A.Chromosome 23 B.Chromosome 21 C.Chromosome18 D.Chromosome 15 E.Chromosome 22 22.Thyroid CA variant with best prognosis is: 23.Thyroid CA which is radiosensitive: 24.Which thyroid CA is chemosensitive? 25.Which thyroid CA is associated with amyloid deposits? 26.Which thyroid CA mostly and firstly involves lymph nodes? 27.Which thyroid CA has hematogenous spread mainly and mostly? Options for Q.22 TO 27 A.Medullary CA B.Thyroid CA C.Follicular CA D.Anaplastic CA E.Papillary CA 28.Which of the following type of cell is least likely to be affected during the progression of type 1 Diabetes Mellitus? A.Alpha cells B.Beta cells C.Delta cells D.PP cells(pancreatic polypeptides) 29.Which of the following is a characteristic of diabetic neuropathy? A.Albuminuria B.Ketoacidosis C.Hyperpigmentation D.Hyponatremia E.Hypernatremia 30.In the pathogenesis of type 1 DM,which of the immune cells are responsible for the destruction of pancreatic beta cells? A……B-lymphocytes B……CD4+ T-cells C ……CD8+ T-cells D……Macrophages 31.Which of the following is a typical finding in diabetic foot ulcers? A.Hyperreflexia B.Hyporeflexia C.Increased sweating D.Impaired wound healing 32.Which of the following molecular pathway is strongly implicated in the development of complications of diabetes like neuropathy and nephropathy etc? A.Wnt/beta-catenin pathway B.Polyol pathway C.JAK-STAT signaling pathway D.Both A and B E.Both B and C 33.Hypoglycemia is seen in: A.Glucagonoma B.Cushing syndrome C.Acromegaly D.Hypopituitarism E.Pheochromocytoma