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Combination therapy may be required for symptom management. Combination therapy is useful when additional medications to target depression symptoms are required. Major Depressive Disorder (MDD): one of the most common mental disorders affecting approx. 7.1% of adults in the US, S/S: Depressed mood,...

Combination therapy may be required for symptom management. Combination therapy is useful when additional medications to target depression symptoms are required. Major Depressive Disorder (MDD): one of the most common mental disorders affecting approx. 7.1% of adults in the US, S/S: Depressed mood, irritability, withdrawal, problems sleeping/eating/energy/concentration or self-worth are all signs and symptoms of major depressive disorder. Pt.’s with severe depression may experience thoughts of suicide/ psychotic symptoms. If antidepressant therapy for major depressive disorder is mistaken for bipolar depression what could happen? It may precipitate a manic episode/ induce a rapid-cycle bipolar depression & contribute to the incidence of death by suicide in children & adults < 25 yrs of age. Monamine neurotransmitters are norepinephrine, dopamine, & serotonin