Biological Chemistry 1A Carbonyl Chemistry Lecture Notes Student PDF

Biological Chemistry 1A Carbonyl Chemistry – Lecture 1 Benjamin N. Bhawal School of Chemistry Joseph Black Building Room 214 [email protected] 1 Learning outcomes 2 Course content 3...

Biological Chemistry 1A Carbonyl Chemistry – Lecture 1 Benjamin N. Bhawal School of Chemistry Joseph Black Building Room 214 [email protected] 1 Learning outcomes 2 Course content 3 Recommended reading 4 Why should you care about organic reactions? 5 Why should you care about organic reactions? 6 Understanding reactivity and reaction mechanisms 7 Understanding reactivity and reaction mechanisms 8 How/why reactions happen 9 How/why reactions happen 10 Remember your basics! 11 Remember your basics! 12 Why should you care about carbonyl chemistry? 13 Coca-Cola 14 Coca-Cola 15 Carbonyl containing functional groups 16 The carbonyl group 17 3D structure of aldehydes– ChemTube 3D https://shorturl.at/dzOEo 18 The carbonyl group – electron distribution 19 Resonance structures 20  Biological Chemistry 1A Carbonyl Chemistry – Lecture 2 Benjamin N. Bhawal School of Chemistry Joseph Black Building Room 214 [email protected] 21 Skills check - Wooclap 22 Where do aldehydes and ketones come from? 23 Reactivity of carbonyl group 24 Nucleophilic addition to carbonyl group 25 3D structure of aldehydes– ChemTube 3D https://shorturl.at/dzOEo 26 Activation of the carbonyl group 27 Nucleophilic addition to aldehydes 28 Nucleophilic addition to aldehydes 29 Nucleophilic addition to aldehydes 30 Aldehydes vs ketones 31 What nucleophiles can we use? 32  Biological Chemistry 1A Carbonyl Chemistry – Lecture 3 Benjamin N. Bhawal School of Chemistry Joseph Black Building Room 214 [email protected] 33 Experiment 3 – functional group analysis 34 Experiment 3 – functional group analysis 35 Experiment 3 – functional group analysis 36 Skills check - Wooclap 37 Grignard reagents 38 Mechanism of Grignard addition to aldehydes 39 Mechanism of Grignard addition to aldehydes 40 Mechanism of Grignard addition – ChemTube 3D https://shorturl.at/6gcIO 41 Hydride reagents 42 Hydride addition to aldehydes 43 Hydride addition to aldehydes 44 Other nucleophiles for nucleophilic addition 45 Ketone – enol tautomerism 46 1,3-dicarbonyls 47 Addition of amines to the carbonyl group 48 Mechanism of imine formation 49 Mechanism of imine formation – ChemTube 3D https://shorturl.at/YMESU 50  Biological Chemistry 1A Carbonyl Chemistry – Lecture 4 Benjamin N. Bhawal School of Chemistry Joseph Black Building Room 214 [email protected] 51 Skills check - Wooclap 52 Carbonyl containing functional groups 53 How do carboxylic acids react? 54 Carboxylic acid derivatives 55 Relative reactivity of carboxylic acid derivatives 56 Relative reactivity of carboxylic acid derivatives 57 Relative reactivity of carboxylic acid derivatives 58 Nucleophilic acyl substitution 59 Leaving groups 60 Leaving groups 61 Mechanism of nucleophilic acyl substitution 62 Mechanism of acyl chloride hydrolysis 63  Biological Chemistry 1A Carbonyl Chemistry – Lecture 5 Benjamin N. Bhawal School of Chemistry Joseph Black Building Room 214 [email protected] 64 Skills check - Wooclap 65 Ester hydrolysis 66 Mechanism of basic ester hydrolysis 67 Mechanism of basic ester hydrolysis 68 Mechanism of acidic ester hydrolysis 69 Mechanism of acidic ester hydrolysis 70 Mechanism of acidic ester hydrolysis 71 Esterification of carboxylic acids 72 Mechanism of acidic ester hydrolysis – ChemTube 3D https://shorturl.at/W4p65 73 Amide versus ester hydrolysis 74  Biological Chemistry 1A Carbonyl Chemistry – Lecture 6 Benjamin N. Bhawal School of Chemistry Joseph Black Building Room 214 [email protected] 75 Skills check - Wooclap 76 Revision question 1 77 Revision question 2 78 Revision question 3 79 Revision question 4 80