Anti epileptic drugs.pdf

anti-epileptic drug recurrent disorder of cerebral function characterised...

anti-epileptic drug recurrent disorder of cerebral function characterised > Epilepsy : by seizures and convulsions sudden attack of involuntary muscular > convulsion - : contractions and relaxations spasms ( DAEDD - Seizure : chronic medical condition sudden changes in the electrical function of the brain limitednumberofcorticol nerstate Focal (Partial) Seizures : - abnormal excessive neuronal discharge assoc. w · person may be aware / have impaired conciousness abnormal electroencephalogram (EEG) activity. T fever arisesimultaneously in both hemisphe a b head trauma Generalised Seizures : To find a cause drug abuse f - Seizures ca · therapy aim to control mo type of seizure > choice of drug - i of pt have their seizure so % generalisedcprim, as · ↑ controlled w medications seizures activity involves - · cence myoclonic tunic-clonic tonic atonic a blinking starring jerking movement stiffening falling , Falling heavily Falling heavily falling of the body ground wo and jerking of the body to the ground to the partial focal seizure activity starts within epilepsy one hemisphere diagnosis abnormal : wave patterns on the EEG simple complex seizures activity while seizures activity with the person is alert change in awareness of surroundings - · each type of epilepsy displays a specific EEG patterns during a seizure Side Effects EEG patterns > choose the drug therapy · - I L Y L Fetal CNS Effects GI Effects Rash Abnormalities therapy helps symptoms and not cure · w. and birth defects browsiness sedation-vertigo - , mouth - Dry No drug has therapeutic effect against · one Depression Headache - - Nausea all type of secure - - Dizziness - confusion - vomitting - slurred speech Tremor Anorexia - - status epilepticus - Diarrhea - Ataxia - Interferance w cognitive fx in learning situations - Nystagmus - life threatening cellular mechanisms of seizures - generalised tonic-clonic convulsions in which the patient is in a state of prolonged continuous seizure activity and Excitation Inhibition unconscious. - ionic-inward Nat , cat currents - a ionic-inward outward ke currents - cause brain damage = medical emergency , - neurotransmitter : glutamate aspartate , - Neurotransmitter : GABA - Hypotension Treatment: Status Epilepticus - Hypoxia Blocks voltage-dependant ion channels - Cardiac dysrhythmias treatments / objectives- - Inhibits activity of glutamate Cf excitatory Enhance the inhibitory activity of GABA