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why wedon'tuseach mati autonomic ns Comparison of somatic and autonomic systems Anatomical Differences in Sympathetic and Nervous System (NS) Parasympathetic Divisions Autonomic Nervous s ina.com Brain Autonomic nervous System Central NS Peripheral NS system: Sensory functions say Motor function 1. Sympathetic – also called the thoracolumbar I division 2. Parasympathetic – am Autonomic NS Somatic NS also called the craniosacral division Sympathetic NS Parasympathetic NS Ei ii.IE i Autonomic Nervous System Sympathetic and Parasympathetic Divisions Anatomical Differences in Sympathetic and Parasympathetic Divisions Functional differences between Sympathetic and Parasympathetic NS w nna Sympathetic Parasympathetic Length of Short long preganglionic fibers Length of Long postganglionic Short postganglionic postganglionic fibers fibers fibers rest Neurotransmitter Acetylcholine for both Acetylcholine released by branches (cholinergic) preganglionic axons Neurotransmitter Mainly release release acetylcholine released by norepinephrine postganglionic axons nurentran.net Copyright © 2005 Pearson Education, Inc., publishing as Benjamin Cummings coiners CENicatin Autonomic Nervous System Receptors involved in parasympathetic Parasympathetic Effector organ Effect(s) Receptor Acetylcholine Acetylcholine LI Nicotinic (N1 or NN) 1- stimulate all autonomic ganglia nervous system 2- secretion of NE and Epi from suprarenal gland Synthesis and Removal of Ach Nicotinic (N2 or NM) Skeletal muscle Skeletal muscle contraction 1. Muscarinic receptors (M): Muscarinic (M1) Stomach Increase HCl secretion Ach is a naturally occurring neurotransmitter that is rapidly hydrolyzed by neuronal acetylcholinesterase achmainytransemete.in Muscarinic receptors occur on all effector Muscarinic (M2) Heart 1. Decrease heart rate -----ve chronotropy (↓ H.R.) Primary transmitter in: cells stimulated by postganglionic 2. Slow heart conductivity ----ve dromotropy and plasma butyrylcholinesterase. 3. Decrease atrial contraction -------ve inotropic effect y cholinergic fibers 1. All autonomic ganglia The effect of ACh binding: Can be either inhibitory or excitatory Muscarinic (M3) Blood vessels Eye Vasodilation due to release of nitric oxide (NO) Miosis, Reduction in IOP (by opening of canal of Schlemm, are Two characteristics render it unsuitable as a drug: 2. Parasympathetic postganglionic neurons Depends on the receptor type of the therefore increases aqueous humor drainage) First its action is very brief. 3. Post-ganglionic I Accommodation to near vision sympathetic to target organ Secondly, it causes such diverse effects that no selective thermoregulatory sweat 2. Nicotinic receptors (N): Respiratory Tract Bronchoconstriction + Increase bronchial secretion action can be utilized. same gland. They are located in the autonomic Exocrine glands www.msn.am increase secretion of glands (salivation, sweating, 4. Neuro-muscular junction lacrimation….. (Skeletal muscles) ganglia, adrenal medulla and skeletal muscle end-plates. Urinary bladder Contraction of urinary bladder wall + Relaxation of ureter and sphincters of UT -------- Facilitate Urination Other derivatives that show some degree of selectivity Nnn and resistance to hydrolysis have been developed. Intestine Increase motility and secretion + Relax sphincters ------- Facilitate defecation anti Parasympathier no iii.ie