Autonomic Nervous System PDF

Autonomic nervous system Dr. Hader I. Sakr Associate professor, Medical Physiology  ‫ﺴﻢ ﷲ اﻟﺮﲪﻦ اﻟﺮﺣﲓ‬ ‫﴿ َواﺗ ُﻘﻮا ا َ ۖ َوﯾ ُ َﻌ ُ ُ َ ُ‬ ‫ا‬‫و‬ ‫ۗ‬ ‫ا‬ ‫ُ‬ ‫ﲂ‬ ‫ُ‬ ‫ﻤ‬‫ّ‬ ‫ِ‬ ‫ﻠ‬ ‫ﳾ ٍء َ ِﻠ ٌﲓ﴾‬ ‫ِ ُ ِّ‬ ‫ﲁ َْ‬ Learning objectives...

Autonomic nervous system Dr. Hader I. Sakr Associate professor, Medical Physiology  ‫ﺴﻢ ﷲ اﻟﺮﲪﻦ اﻟﺮﺣﲓ‬ ‫﴿ َواﺗ ُﻘﻮا ا َ ۖ َوﯾ ُ َﻌ ُ ُ َ ُ‬ ‫ا‬‫و‬ ‫ۗ‬ ‫ا‬ ‫ُ‬ ‫ﲂ‬ ‫ُ‬ ‫ﻤ‬‫ّ‬ ‫ِ‬ ‫ﻠ‬ ‫ﳾ ٍء َ ِﻠ ٌﲓ﴾‬ ‫ِ ُ ِّ‬ ‫ﲁ َْ‬ Learning objectives: ANS neurotransmitters, fibers and receptors: o Distribution. o Mode of action. o Drugs acting on them Alarm response. Drugs that affect the autonomic activity  Drugs that affect the autonomic activity - The junctions in the efferent autonomic pathway are a logical site for pharmacological manipulation because transmission at them is chemical. - The steps of neurotransmitter synthesis, storage, release, breakdown, reuptake or receptor binding can be stimulated or inhibited by drugs. Drugs that affect the Parasympathetic Nervous System Drugs that affect the autonomic activity ↓ Parasympathetic  Drugs that affect the autonomic activity Drugs that affect the Sympathetic Nervous System Drugs that affect the autonomic activity Drugs that affect the autonomic activity Conclusion Transmission within the ANS is chemically-mediated. Autonomic fibers could be either cholinergic or adrenergic. Each type has its own distribution, neurotransmitter, receptors and mechanism of action. Sympathetic nervous system discharges as one unit in emergency situations which is known as “Alarm response”. There are large number of drugs affecting the ANS activity at its different levels, either through stimulation or inhibition. References Guyton and Hall, 13th edition. Unit II(6); 81-2. Ganong’s review of medical physiology 25th ed. Section I(5); 107-10. Thank You