Pathogenic Actions of Bacteria PDF

Summary

These notes discuss the pathogenic actions of bacteria, covering topics such as bacterial colonization, host-cell adhesion, invasion, virulence factors, exotoxins, and endotoxins, as well as the host's immune response and the evasion of host defenses. Different bacterial types and their actions are detailed.

Full Transcript

O livehere bacteria's containthemostmicrobiota I microbecapable capacityof a microbe ofcausinghostdamage tocausedamagein host Tentaspartofnormal microbiota ...

O livehere bacteria's containthemostmicrobiota I microbecapable capacityof a microbe ofcausinghostdamage tocausedamagein host Tentaspartofnormal microbiota infectedindividuals animals vectors reserviors contaminatedfood water howwe are exposedto pathogens how pathogensenterthebody ingestion inhalation arthropodbites Provideformidable ftp fjy barrier intactskin excellentdefense blockingalmostall Pathogens somebacterialdiseases resultfromtoxins eitherpremade food or producedinsidethebody ratherthanfrom the bacteria physically invadingtissues enable bacteriato resistflushing competewithothermicrobesforniches andfirmlyattachto hosttissuesfor colonization invasion to move adhesins specialproteinsor structuresthat helpbacteriastickto specifictissues location onhairlikestructuressurrounding bacteria Ictcellsliningmucosal somebacteria 1 directly 2 followinga periodof colonization supportcolonization 1 2 3 Pathogenspread a s dueto degradativeenzymes byproducts of bacterialgrowth damagecytoplasmicmembrane tissues disruptkeybiologicalactivities harm harmfulin lowconc recognizebacterial cellwallcomponents recognizestructureson bacteria f result Pyrogenicacutephaseresponse Gtve G ve Bacterialtriggers at lowlevels 1 helpbodybycausingfever 3 activationofimmune 2 vasodilation inflammatoryresponses maybesecretedorreleasedduringlysisofthecell activate Tcell Proinflammatorycytokines Tproliferation effects potentiallygiverisetopathologicalsystemic causedbyneutrophil macrophage complement I causedbyinflammation swelling microcoagulation when circulatingantigenantibody complexes can causedamage atdistantsites directviralcytopathogenesis viralimmunopathogenesis virulence status nagtional Polysaccharidecapsule sheltering Protectedzone Producingenzymes ormediators for microbes to survivefor extended periods virusespersistinhost as 1 Virions 2 Chromosomally integrated Provivalgenomes Routesoftransmission 1respiratory 2 fecaloral 3 Sexual 4 vectorborne 5 vertical 2 10 ratio

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