IMG_AC8852F00BC2-3.jpeg

Here's the information from the image, formatted into markdown: ## Bio of the Brain ### Similar words * Classical / operant conditioning ### Implicit * Priming * Procedural * Associative learning * Non-associative learning * Skills + habits ### Hunger state * Recall food images...

Here's the information from the image, formatted into markdown: ## Bio of the Brain ### Similar words * Classical / operant conditioning ### Implicit * Priming * Procedural * Associative learning * Non-associative learning * Skills + habits ### Hunger state * Recall food images easier when hungry (unconscious memory) ### HM * Medial temporal lobe resection (hippocampus + amygdala, etc...) * Medial temp. lobe linked to mem. * **Hippocampus + H. gyrus needed for encoding + consolidating explicit mem.** * anterograde amnesia - mostly normal otherwise ### KC * Hippocampus + parahippocampal gyrus damage ### Retro + anterograde amnesia * Episodic mem. lost, semantic retained ### BJ * Injured mammillary bodies * Brain-wide network also important ### Retro + anterograde amnesia ### Cortical association areas * Different objects stored in different areas ### Amnesiacs * ↑ performance on mirror task despite no memory of doing it * able to be primed * good at prediction task, bad on declarative mem task ### Parkinson's patients * bad at prediction task, perfect on declarative mem task * better on L-DOPA ### Morris Water Maze * Hippocampus needed for spatial learning * Place cells: Pyramidal neurons (fire when in a specific place) * Rotate w/ rotation of external land marks ### Grid cells * In medial entorhinal cortex (input to hippoc.) * Fire at evenly spaced locations to make Euclidean map (means of navigation) ### Hebb's Postulate * Repeated excitement of 1 neuron = growth to ↑ efficiency ### Synaptic plasticity * Change in strength of synaptic transmission (short + long term) ### Glutamatergic Synapse * Supramolecular complex - axon terminal boutons + postsynaptic dendritic spines ### Bliss/Lomo * In vivo rabbit hippocampus - extracellular field recording - perforant path * Activity-dependent info. storage in CNS ### Synaptic Plasticity | | Short T | Long T | | :------------------- | :-------------------------- | :-------------------- | | | | \> 1hr | | Pre-synaptic | | Post-synaptic | | msec - min | | Potentiation: ↑ | | Facilitation: ↑ Ca2+ | | Depression: ↓ Strength | | Depression: ↓ NT | | | 1. Cooperativity: Weak inputs close in time = retained 2. Associativity: weak input paired w/ strong = retained 3. Synapse specificity: info. only stored at activated synapses 4. Persistence: LTP stays 1hr-> \> 1yr