MED6012 Rational Pharmacotherapy Final Question Booklet 2024-2025 Fall Semester PDF

BAU INTERNATIONAL UNIVERSITY MEDICINE PROGRAM MED6012 Rational pharmacotherapy Final QUESTION BOOKLET 2024-2025 FALL SEMESTER Booklet Type: B Student ID No : Name, Surname: Signature : ********************************************************************...

BAU INTERNATIONAL UNIVERSITY MEDICINE PROGRAM MED6012 Rational pharmacotherapy Final QUESTION BOOKLET 2024-2025 FALL SEMESTER Booklet Type: B Student ID No : Name, Surname: Signature : ************************************************************************* 1. To which type of hypersensitivity reactions 4. To which type of hypersensitivity reactions angioedema belongs to: drug-induced hemolytic anemia belongs to: a. 1st type, (correct) a. 1st type, nd b. 2 type, b. 2nd type, (correct) c. rd 3 type, c. 3rd type, th d. 4 type d. 4th type 2. To which type of hypersensitivity reactions urticaria belongs to: 5. Hematopoetic toxicity includes: a. agranulocytosis, a. 1st type, (correct) b. thrombocytopenia, b. 2nd type, c. pancytopenia, c. 3rd type, d. all the mentioned options th d. 4 type (correct) 3. To which type of hypersensitivity reactions 6. Hematopoetic toxicity of drugs: anaphylactic shock belongs to: a. is irreversible, a. 1st type, (correct) b. reversible with cessation for b. 2nd type, most of the drugs, (correct) c. always requires bone c. 3rd type, marrow transplantation, d. 4th type d. no correct option 7. Choose the type of anemia which is not 12. Choose the tissues/organs where the drug related to drug administration: could be metabolized: a. aplastic, a. liver, b. iron deficient, (correct) b. intestine, c. hemolytic, c. plasma d. B12-deficient d. in all the mentioned tissues/organs (correct) 8. Cases of agranulocytosis require: 13. Active drug after metabolism: a. immediate administration of antibiotics, (correct) a. may have active metabolites, b. blood transfusion, b. may be transformed into an inactive metabolite, c. erythropoetins, c. options 1 and 2 are correct, d. no correct option (correct) 9. Mechanisms of nephrotoxicity of the drugs include: d. no correct answer. 14. Prodrug: a. interstitial nephritis, a. must be transformed into an b. renal tubular necrosis, active form by metabolism, c. decreased filtration, (correct) d. all the mentioned options b. is effective in any case of (correct) use, 10. Cases of cellular hepatotoxicity of drugs c. can be administered only in are characterized with: small doses, a. increased liver enzymes, d. no correct answer. (correct) 15. Biotransformation of drugs occurs: b. hypocoagulation, a. in two phases, (correct) c. hypersensitivity, b. in ten phases, d. no correct option. c. in 20 phases, 11. In case of cellular hepatotoxicity of the d. no correct answer drug, discontinuation is required if: 16. Phase 2 of drug biotransformation a. liver enzymes are increased involves: three times above normal range, (correct) a. synthetic chemical reactions, b. liver enzymes are increased b. conversion of the molecule to 10x times above normal range, a more hydrophilic one, c. the drug should not be c. both options are correct, discontinued, (correct) d. no correct option. d. none of the answers are correct. 17. Phase 1 of drug biotransformation b. increase, (correct) involves: c. remain unchanged, a. hydroxylation, d. no correct answer b. dealkylation, 22. Drug A is an active drug. Drug B induces c. deamination, the enzyme responsible for converting Drug A into its inactive form. How will the d. all of the mentioned above. effectiveness of drug A be changed when (correct) taken simultaneously with drug B: 18. Most drug biotransformation reactions a. decrease, (correct) involve: b. increase, a. cytochrome 3A4, (correct) c. remain unchanged, b. P-GlycoProtein, d. no correct answer c. cytochrome 1A2, 23. Phase 2 synthetic reactions in the liver: d. no correct answer. 19. Drug A is a prodrug. Drug B inhibits the a. requires energy, (correct) enzyme responsible for converting Drug A b. requires intensive blood flow, into its active form. How will the c. requires good tissue effectiveness of Drug A be changed when oxygenation, taken simultaneously with Drug B: d. no correct answer a. decrease, (correct) 24. Types of phase 2 reactions: b. increase, a. glucuronidation, c. remain unchanged, b. acetylation, d. no correct answer. c. sulfation, 20. Drug A is a prodrug. Drug B induces the enzyme responsible for converting Drug A d. all of the mentioned above into its active form. How will the (correct) effectiveness of Drug A be changed when 25. Glucuronides can be excreted: taken simultaneously with Drug B: a. with bile, a. decrease, b. through the kidneys, b. increase, (correct) c. both options are correct, c. remain unchanged, (correct) d. no correct answer d. no correct option. 21. Drug A is an active drug. Drug B inhibits 26. In the case of excretion with bile, the enzyme responsible for converting Drug A glucuronides: into its inactive form. How will the a. enter the intestine and can be effectiveness of Drug A be changed when hydrolyzed by beta- taken simultaneously with Drug B: glucuronidase, a. decrease, b. some of the hydrolyzed  compounds will be reabsorbed options can be correct. into the portal vein system, (correct) c. both options are correct, 31. The risk of drug interactions increases if: (correct) a. more than 1 drug is d. no correct option. prescribed, 27. Possible drug interactions: b. the patient has several diseases, a. pharmaceutical (in the syringe), c. the patient is of extreme age, b. pharmacological (in the d. all the mentioned options are body), correct (correct) c. both options are correct, 32. Possible drug interactions: (correct) a. with other drugs, d. none of the options are b. with food, correct. c. with medicinal supplements, 28. Pharmaceutical interactions are possible: d. all of the mentioned above a. during preparation of the are correct (correct) dosage form, 33. Drug-drug interactions: b. during administration, a. most reactions are known c. during dissolution of drugs and predictable. (correct) in a solvent, b. most reactions are unknown d. all of the mentioned above and unpredictable, options are correct (correct) c. both options are correct, 29. Pharmacological drug interactions are possible: d. no correct answer. a. through pharmacodynamic, 34. Drug interactions with food: b. through pharmacokinetic, a. partially predictable, (correct) c. both options are correct, (correct) b. never predictable, d. none of the options are c. always predictable, correct. d. no correct option 30. In the case of a pharmacokinetic 35. Options for changing the therapeutic interaction (between drug A and B), drug A: effect during drug-drug interactions: a. changes the absorption of a. abnormal response, drug B, b. increased effect, b. the distribution of drug B, c. decreased effect, c. the metabolism of drug B, d. all of the mentioned above d. all of the mentioned above are correct. (correct) 36. If drug A enhances the therapeutic effect a. antagonists, of drug B, then drugs A and B are: b. synergists, (correct) a. synergists, (correct) c. synergo-antagonists, b. antagonists, d. no correct answer c. synergo-antagonists, 42. Benzodiazepines and opioids by their d. no correct option effect on the central nervous system: 37. If drug A weakens the therapeutic effect of a. antagonists, drug B, then drugs A and B are: b. synergists, (correct) a. synergists, c. synergo-antagonists, b. antagonists, (correct) d. no correct answer c. synergo-antagonists, 43. 1st generation antihistamines and d. no correct option benzodiazepines by their effect on sleep: 38. Rational combinations of drugs: a. antagonists, a. enhance the therapeutic b. synergists, (correct) effect, c. synergo-antagonists, b. decrease each other's side d. no correct answer effects, 44. Atropine (M-anticholinergic) and beta- c. both options are correct, blockers by their effect on heart rate: (correct) a. antagonists, (correct) d. no correct answer. b. synergists, 39. Food can affect drug absorption: c. synergo-antagonists, a. by binding (chelating) the drug, d. no correct answer b. changing gastric pH, 45. Non-dihydropyridine calcium channel blockers (verapamil) and beta-blockers by c. changing gastrointestinal effect on heart rate: motility, a. antagonists, d. by all of the mentioned above options. (correct) b. synergists, (correct) 40. Grapefruit juice: c. synergo-antagonists, a. inhibits enzyme 3A4, d. no correct option (correct) 46. Dobutamine (beta1-mimetic) and Atropine b. inhibits drug excretion, (anticholinergic) by effect on heart rate: c. affects drug distribution, a. antagonists, d. no correct answer b. synergists, (correct) 41. Benzodiazepines and opioids by their c. synergo-antagonists, effect on respiration: d. no correct option 47. Salbutamol (beta2-mimetic) and b. potatoes, propranolol (non-selective beta-blocker) by c. carrots, effect on bronchi: d. no correct answer a. antagonists, (correct) 53. In case of taking MAO inhibitors, the b. synergists, following should be excluded: c. synergo-antagonists, a. foods rich in tyramine, d. no correct option (correct) 48. Nitroglycerin drugs and peripheral b. foods rich in vitamin C, alpha1-adrenergic agonists by effect on blood c. foods rich in carbohydrates, pressure: d. no correct answer a. antagonists, (correct) 54. In case of taking Selective Serotonin b. synergists, Reuptake Inhibitors (SSRIs), the following c. synergo-antagonists, should be excluded: d. no correct option a. foods rich in tyramine, (correct) 49. Nitrates and naltrexone (mu-opioid receptor antagonist) by effect on blood b. foods rich in vitamin C, pressure: c. carbohydrate-rich foods, a. antagonists, (correct) d. no correct answer b. synergists, 55. If ACE inhibitors are prescribed to treat c. synergo-antagonists, hypertension, then it is rational to: d. no correct answer a. reduce the amount of sodium chloride consumed, (correct) 50. M3-anticholinergics and beta2-mimetics by effect on the bronchi: b. increase the amount of sodium chloride, a. antagonists, c. increase the amount of b. synergists, (correct) carbohydrates, c. synergo-antagonists, d. no correct answer. d. no correct answer 56. The absorption of acetylsalicylic acid in 51. Warfarin metabolism (via cytochrome the stomach is increased by: CYP2C9) can be slowed down by: a. acidic foods, (correct) a. cranberry juice, (correct) b. neutral foods, b. grapefruit juice, c. alkaline foods, c. apple juice, d. no correct answer d. no correct answer 57. Caffeine in relation to beta2-agonists: 52. Warfarin pharmacodynamics can be a. antagonists, changed by: b. synergists, (correct) a. spinach, (correct)  c. synergo-antagonists, c. Osmotic pressure d. no correct answer d. Hydrostatic pressure 58. How is the amount of albumin in a woman's body changed during pregnancy? 63. In case pKa of drug is equal to pH of a. Decreases, (correct) tissue: b. Increases, a. The drug will not have an action c. Is not changed, b. 50% of the drug will be ionized (correct) d. no correct answer c. the drug will not be eliminated 59. The only beta-blocker approved for use during pregnancy (in case of d. The drug will not be metabolized hyperthyroidism) is: a. propranolol, (correct) 64. Weak acid drugs will be ionized in: b. nebivolol, a. tissues with neutral pH c. carvedilol, b. tissues with base pH (correct) d. no correct answer. c. tissues with acid pH 60. After applying the fentanyl patch, the d. will not be ionized in the body patch begins to act: a. 24 hours after application, (correct) 65. Weak base drugs will be ionized in: b. 10 minutes after application, a. tissues with neutral pH c. one hour after application, b. tissues with base pH d. no correct answer. c. tissues with acid pH (correct) d. will not be ionized in the body 61. Drug metabolism supposes that the drug should be transformed to: 66. Food in stomach: a. non-polar molecules a. Can interact with the drug given b. Proteins enterally (correct) c. Nucleic acids b. Affects drug distribution d. water-soluble form for excretion c. Affects drug elimination (correct) d. Affects drug excretion 62. Moving force to deliver lipid-soluble drug 67. Drugs, affecting GI motility: to tissues: a. Slow down the metabolism of the a. Concentration gradient (correct) drugs b. Special carriers of molecules b. Slow down the excretion of the drugs  c. Affects also plasma protein binding c. can occur when the drug is excreted with the bile (correct) d. can also affect drug absorption from GI tract (correct) d. means that the drug is excreted with urine 68. Water-soluble drugs, given SC and IM: 73. In case the drug is administered topically: a. will not be absorbed a. bioavailability is high b. will not be excreted b. bioavailability is negligible (correct) c. will not be metabolized c. the drug is excreted fast d. reach systemic circulation through lymphatic vessels (correct) d. the drug is metabolized fast 69. Lipid-soluble drugs, given SC and IM: 74. Single-compartment model of distribution supposes that: a. reach systemic circulation through capillary endothelium (correct) a. the drug will affect only one type of tissues b. will not be absorbed b. the drug will have a short action c. will not be excreted c. the drug is not metabolized d. will not be metabolized d. the drug is distributed equally in all the tissues (correct) 70. The route with the fastest absorption: a. Intramuscular (correct) 75. Weak base and weak acid drugs will be b. Enteral bound to: c. Topical a. albumins, lipoproteins (correct) d. Transdermal b. Immune globulins c. liver enzymes 71. Mucous membranes: d. transferrin a. are permeable for lipid-soluble drugs (correct) 76. Drugs with high level of plasma protein b. are not permeable for lipid-soluble binding: drugs a. are excreted faster c. are permeable for water-soluble drugs b. are restricted in vessels (correct) d. cannot interact with the drug c. are concentrated in CNS d. are metabolized faster 72. Entero-hepatic circulation: a. Makes half-life time shorter 77. State of hypoproteinaemia will: b. Prevents the drug from transformation  a. Increase the absorption of the drug drug: b. increace plasma protein binding a. half-life of the drug is constant (correct) c. decrease the absorption of the drug b. The drug is not absorbed d. Increases free part of the drug in plasma (correct) c. The drug is not metabolized d. The drug is not excreted 78. Phase 2 of drug metabolism: a. Takes place in kidneys 80. In 5 half-life periods: b. Makes drug metabolism shorter a. 15% of the drug will be eliminated c. Affects GI motility b. 95% of the drug will be eliminated (correct) d. supposes that the drug will be conjugated with glucuronic acid to c. 35% of the drug will be eliminated make the drug more polar (correct) d. 65% of the drug will be eliminated 79. In case of 1st order elimination of the