Cardiovascular Therapeutics PDF

You are listening to ‘Heart Attack’ by Demi Lovato Therapeutics for Cardiovascular Disease Dr Martin Hawes Senior Lecturer in Veterinary Pharmacology and...

You are listening to ‘Heart Attack’ by Demi Lovato Therapeutics for Cardiovascular Disease Dr Martin Hawes Senior Lecturer in Veterinary Pharmacology and Therapeutics Sunday, 10 December 2023 1  Learning Outcomes Sunday, 10 December 2023 2  Links to other modules Sunday, 10 December 2023 3  Functional Problems of the Cardiovascular System Sunday, 10 December 2023 4  Drugs that affect cardiac function Sunday, 10 December 2023 5  Drugs that affect cardiac function Sunday, 10 December 2023 6  Drugs that affect myocardial cells directly 1. Antidysrhythmic Drugs Sunday, 10 December 2023 7  Cardiac action potential Sunday, 10 December 2023 8  Cardiac action potential Sunday, 10 December 2023 9  Sympathetic & parasympathetic inputs Adrenergic receptors Heart - mainly β1 Increase rate Airway - mainly β2 Bronchodilation Muscarinic receptors Heart – mainly M2 Slow rate Airway – mainly M3 Bronchoconstriction Sunday, 10 December 2023 10  Antidysrhythmic drugs (Vaughan Williams classification) Sunday, 10 December 2023 11  Antidysrhythmic Class I Sunday, 10 December 2023 12  Class II – β-adrenoceptor antagonists Sunday, 10 December 2023 13  Class III – K+ channel blockers Sunday, 10 December 2023 14  Class IV – Ca2+ channel blockers Sunday, 10 December 2023 15  Other antidysrhythmic agents Sunday, 10 December 2023 16  Sympathetic & parasympathetic inputs Adrenergic receptors Heart - mainly β1 Increase rate Airway - mainly β2 Bronchodilation Muscarinic receptors Heart – mainly M2 Slow rate Airway – mainly M3 Bronchoconstriction Sunday, 10 December 2023 17  Bradyarrhythmia Sunday, 10 December 2023 18  Antidysrhythmic medication - Summary ( ) Sunday, 10 December 2023 19  Drugs that affect myocardial cells directly 2. Cardiac glycosides and other inotropic drugs Sunday, 10 December 2023 20  Cardiac glycosides Sunday, 10 December 2023 21  Inodilators Sunday, 10 December 2023 22  Other drugs that increase myocardial contraction Sunday, 10 December 2023 23  Drugs that affect cardiac function indirectly (pre-load / after-load) Sunday, 10 December 2023 24  Main mechanisms of blood pressure regulation Sunday, 10 December 2023 25  Main mechanisms of blood pressure regulation Sunday, 10 December 2023 26  Renin-Angiotensin-Aldosterone System Angiotensin II Receptor Blockers (ARBs) e.g. telmisartan now licenced in cats Sunday, 10 December 2023 27  Diuretics Sunday, 10 December 2023 28  Loop diuretics Sunday, 10 December 2023 29  Aldosterone receptor antagonists Sunday, 10 December 2023 30  Thiazide diuretics Sunday, 10 December 2023 31  Calcium channel blockers Sunday, 10 December 2023 32  Congestive Heart Failure - Dogs Sunday, 10 December 2023 33  Congestive Heart Failure - Cats Sunday, 10 December 2023 34 Sunday, 10 December 2023 35 Sunday, 10 December 2023 36 Sunday, 10 December 2023 37 Sunday, 10 December 2023 38  Further reading Sunday, 10 December 2023 39