Translational Biotechnology Overview PDF

Translational Biotechnology Overview Lecture notes by Olga Abian  Translational Biotechnology 1. Biotechnology applications 2. Translation of basic scientific discoveries to clinical applications A. Drug Development: Protein drugs, Hormones, Monoclonal antibodies,...

Translational Biotechnology Overview Lecture notes by Olga Abian  Translational Biotechnology 1. Biotechnology applications 2. Translation of basic scientific discoveries to clinical applications A. Drug Development: Protein drugs, Hormones, Monoclonal antibodies, Cytokines, Vaccines B. Nanomedicine C. Gene therapy D. Precision medicine/Biomarker development E. Microbial engineering for bio-therapeutics F. Application of big data and translational bioinformatics 3. Conclusions Biotechnology applications Biotechnology is an advanced field of biology that exploits technology to make and disseminate biological discoveries for human benefit Biotechnology applications Microbial Bioconversion From www.takarabio.com Vaccine development DOI: 10.2174/1389201020666190618115821 Therapeutic Proteins DOI: 10.1007/978-3-030-00710-2 Translation of basic scientific discoveries to clinical applications Translation of basic scientific discoveries to clinical applications DRUG Big data and Development translational bioinformatics Microbial engineering for bio- therapeutics NANOMEDICINE GEN THERAPY Precision medicine and biomarker development Translation of basic scientific discoveries to clinical applications: Drug development DRUG Development DOI: 10.1007/978-981-13-1562-6_14 Translation of basic scientific discoveries to clinical applications: Drug development Protein drugs DRUG Development Translation of basic scientific discoveries to clinical applications: Drug development https://www.maximizemarketresearch.com/ Translation of basic scientific discoveries to clinical applications: Drug development Translation of basic scientific discoveries to clinical applications: Drug development Recombinant Protein Production Practical Case we will do in next lessons: - PCR - Cloning mutagenesis - Expression systems Translation of basic scientific discoveries to clinical applications: Drug development Protein drugs DRUG Development Translation of basic scientific discoveries to clinical applications: Drug development Monoclonal antibodies Translation of basic scientific discoveries to clinical applications: Drug development Monoclonal Antibody Production Practical Case: Hybridome technology Translation of basic scientific discoveries to clinical applications: Drug development Protein drugs DRUG Development Translation of basic scientific discoveries to clinical applications: Drug development Recombinant vaccines Translation of basic scientific discoveries to clinical applications: Drug development Recombinant vaccines Whole Pathogen Vaccines Subunit Vaccines Nucleic Acid Vaccines Viral Vectored Vaccines DOI: 10.1038/s41577-020-00480-0 Translation of basic scientific discoveries to clinical applications: Drug development Recombinant vaccines From: https://www.genscript.com/ Translation of basic scientific discoveries to clinical applications: Drug development Recombinant viral vaccines DOI: 10.1016/j.vaccine.2019.08.031  Vaccines Production Practical Case: Classify these commercial vaccines in the different groups  Vaccines Practical Case: Classify these commercial Production vaccines in the different groups Commercial Disease Type(A,B,C,D) Production: EMA Assessment Cell culture (procaryotic Name Subtype(1-3A,1-5B,1-2C,1-2D) or eucaryotic) report Bexsero Havrix PreHevbri Vaxelis Rotarix Gardasil Menveo Comirnaty Vaxzevria PHH-1V Translation of basic scientific discoveries to clinical applications: Drug development Therapeutic Proteins DRUG Development Translation of basic scientific discoveries to clinical applications: Drug development Therapeutic Proteins DRUG Development DOI: 10.1016/B978-0-12-804659-3.00019-1 Translation of basic scientific discoveries to clinical applications: Drug development Cytokines DRUG Development https://go.drugbank.com/categories/DBCAT000079 Translation of basic scientific discoveries to clinical applications DRUG Big data and Development translational bioinformatics Microbial engineering for bio- therapeutics NANOMEDICINE GEN THERAPY Precision medicine and biomarker development Translation of basic scientific discoveries to clinical applications: Nanomedicine NANOMEDICINE doi.org/10.3390/jpm7040012 doi.org/10.3390/nano10112186 Translation of basic scientific discoveries to clinical applications: Nanomedicine NANOMEDICINE doi.org/10.3390/jpm7040012 Translation of basic scientific discoveries to clinical applications: Nanomedicine NANOMEDICINE Translation of basic scientific discoveries to clinical applications DRUG Big data and Development translational bioinformatics Microbial engineering for bio- therapeutics NANOMEDICINE GEN THERAPY Precision medicine and biomarker development Translation of basic scientific discoveries to clinical applications: Gen Therapy GEN THERAPY https://www.fda.gov/ Translation of basic scientific discoveries to clinical applications: Gen Therapy GEN THERAPY https://www.yourgenome.org Translation of basic scientific discoveries to clinical applications: Gen Therapy GEN THERAPY DOI: 10.1186/s12943-021-01431-6 Translation of basic scientific discoveries to clinical applications DRUG Big data and Development translational bioinformatics Microbial engineering for bio- therapeutics NANOMEDICINE GEN THERAPY Precision medicine and biomarker development Translation of basic scientific discoveries to clinical applications: Precision medicine and biomarker development Precision medicine and biomarker development Translation of basic scientific discoveries to clinical applications: Precision medicine and biomarker development Precision medicine and biomarker development Translation of basic scientific discoveries to clinical applications: Precision medicine and biomarker development Precision medicine and biomarker development DOI: 10.3390/biom12081021 Translation of basic scientific discoveries to clinical applications DRUG Big data and Development translational bioinformatics Microbial engineering for bio- therapeutics NANOMEDICINE GEN THERAPY Precision medicine and biomarker development Translation of basic scientific discoveries to clinical applications: Microbial engineering for bio-therapeutics Microbial engineering for bio- therapeutics DOI: 10.1002/adma.202102580 Translation of basic scientific discoveries to clinical applications: Microbial engineering for bio-therapeutics Microbial engineering for bio- therapeutics DOI: 10.1016/j.copbio.2020.05.006 Translation of basic scientific discoveries to clinical applications: Microbial engineering for bio-therapeutics Microbial engineering for bio- therapeutics DOI: 10.1016/j.copbio.2020.05.006 Translation of basic scientific discoveries to clinical applications DRUG Big data and Development translational bioinformatics Microbial engineering for bio- therapeutics NANOMEDICINE GEN THERAPY Precision medicine and biomarker development Translation of basic scientific discoveries to clinical applications: Big data and translational bioinformatics Big data and translational bioinformatics DOI: 10.1016/B978-0-323-89824-9.00001-X Translation of basic scientific discoveries to clinical applications: Big data and translational bioinformatics Big data and translational bioinformatics DOI: 10.1016/B978-0-12-821972-0.00004-6 Translation of basic scientific discoveries to clinical applications: Conclusions DOI: 10.3390/biotech11030023 Translation of basic scientific discoveries to clinical applications: Conclusions