Which therapy is a dimeric fusion protein that targets IL-1?
Understand the Problem
The question is asking for a specific therapy that is a dimeric fusion protein targeting IL-1. To answer it, we need to identify the correct option based on the properties of the listed therapies.
Answer
Rilonacept
The final answer is Rilonacept.
Answer for screen readers
The final answer is Rilonacept.
More Information
Rilonacept functions as a decoy receptor, neutralizing IL-1α and IL-1β to block their signaling pathways. It is used to treat conditions like cryopyrin-associated periodic fever syndromes and recurrent pericarditis.
Tips
A common mistake is confusing dimeric fusion proteins with monoclonal antibodies, which also target cytokines like IL-1 but have different structures and mechanisms.
Sources
- Rilonacept - an overview | ScienceDirect Topics - sciencedirect.com
- IL-1 Trap Rilonacept for Recurrent Pericarditis: RHAPSODY Study - acc.org
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