Which of the following statements accurately describes the role of renal sodium-glucose cotransporters (SGLT) in glucose homeostasis? A) SGLT1 is the primary transporter responsibl... Which of the following statements accurately describes the role of renal sodium-glucose cotransporters (SGLT) in glucose homeostasis? A) SGLT1 is the primary transporter responsible for glucose reabsorption in the kidneys. B) SGLT1 and SGLT2 promote glucose excretion in the urine, regardless of blood glucose levels. C) SGLT inhibitors increase glucose reabsorption in the kidneys, lowering blood glucose. D) SGLT2 inhibitors block glucose reabsorption in the kidneys, increasing glucose excretion and lowering blood glucose.
Understand the Problem
The question is asking us to identify which statement correctly describes the function of renal sodium-glucose cotransporters (SGLT) in the process of glucose homeostasis, primarily focusing on their role in glucose reabsorption or excretion in the kidneys.
Answer
SGLT2 inhibitors block glucose reabsorption in the kidneys, increasing glucose excretion and lowering blood glucose.
The final answer is D) SGLT2 inhibitors block glucose reabsorption in the kidneys, increasing glucose excretion and lowering blood glucose.
Answer for screen readers
The final answer is D) SGLT2 inhibitors block glucose reabsorption in the kidneys, increasing glucose excretion and lowering blood glucose.
More Information
SGLT2 is mainly responsible for glucose reabsorption in the kidney, and its inhibition leads to increased glucose excretion, which helps lower blood glucose levels.
Tips
A common confusion is assuming that SGLT1 plays a major role in renal glucose reabsorption, while it primarily functions in the small intestine.
Sources
- Sodium-Glucose Co-transporters and Their Inhibition - cell.com
- Sodium-Glucose Transport Protein 2 (SGLT2) Inhibitors - NCBI - ncbi.nlm.nih.gov
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