Which condition requires a reduction in dose due to high bleeding risk? A) Patient under 50 years with no medical history B) Patient on Verapamil C) Patient aged 75 years D) Patien... Which condition requires a reduction in dose due to high bleeding risk? A) Patient under 50 years with no medical history B) Patient on Verapamil C) Patient aged 75 years D) Patient with CrCl of 20 ml/min
Understand the Problem
The question is asking about specific patient conditions that necessitate a decrease in medication dosage because of an increased risk of bleeding. It presents different patient scenarios, and we need to identify which one requires a dose reduction.
Answer
Patient with CrCl of 20 ml/min.
The condition that requires a reduction in dose due to high bleeding risk is: Patient with CrCl of 20 ml/min.
Answer for screen readers
The condition that requires a reduction in dose due to high bleeding risk is: Patient with CrCl of 20 ml/min.
More Information
Patients with a creatinine clearance (CrCl) of 20 ml/min have reduced kidney function, which can lead to accumulation of certain medications in the body, increasing the risk of bleeding with anticoagulants.
Tips
A common mistake is underestimating the impact of renal function on drug clearance, which is critical in patients prescribed anticoagulants.
Sources
- Stroke Prevention in Patients With Atrial Fibrillation and Renal ... - ahajournals.org
- Non–Vitamin K Antagonist Oral Anticoagulant Dosing in Patients ... - sciencedirect.com
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