What percentage of synapse density loss is typically observed in patients with Alzheimer's Disease (AD)?
Understand the Problem
The question is asking about the typical percentage of synapse density loss that is observed in patients suffering from Alzheimer's Disease. It includes multiple choice answers to quantify the degree of loss.
Answer
15–20% synapse density loss in early Alzheimer's stages.
Patients with Alzheimer's Disease typically experience a 15–20% synapse density loss in the neocortex and limbic system during mild cognitive impairment and early stages of the disease.
Answer for screen readers
Patients with Alzheimer's Disease typically experience a 15–20% synapse density loss in the neocortex and limbic system during mild cognitive impairment and early stages of the disease.
More Information
Synaptic loss in Alzheimer's Disease is a major pathological feature that strongly correlates with cognitive decline, highlighting the importance of synapse preservation in potential therapies.
Sources
- Synapse pathology in Alzheimer's disease - ScienceDirect.com - sciencedirect.com
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