What is the pathology of Intravascular hemolysis?
Understand the Problem
The question is asking to describe the disease process of Intravascular hemolysis, that is, the destruction of red blood cells within blood vessels.
Answer
Intravascular hemolysis involves RBC destruction within vessels, releasing contents into plasma, impairing NO availability, causing oxidative stress, and affecting vasoconstriction.
The pathology of intravascular hemolysis involves the destruction of red blood cells within the blood vessels, leading to the release of hemoglobin and other cell contents into the plasma. This process can impair nitric oxide (NO) bioavailability, cause oxidative stress, and alter the redox balance. These physiological changes promote vasoconstriction, blood vessel remodeling, and can contribute to conditions like sickle cell disease.
Answer for screen readers
The pathology of intravascular hemolysis involves the destruction of red blood cells within the blood vessels, leading to the release of hemoglobin and other cell contents into the plasma. This process can impair nitric oxide (NO) bioavailability, cause oxidative stress, and alter the redox balance. These physiological changes promote vasoconstriction, blood vessel remodeling, and can contribute to conditions like sickle cell disease.
More Information
Intravascular hemolysis can lead to complications such as vasoconstriction and blood vessel remodeling due to its impact on NO and oxidative stress. It is a key factor in the pathophysiology of diseases like sickle cell anemia.
Tips
A common mistake is confusing intravascular hemolysis with extravascular hemolysis, which occurs when RBCs are removed primarily in organs like the spleen, rather than within the blood vessels.
Sources
- Intravascular hemolysis - Wikipedia - en.wikipedia.org
- Clinical Sequelae of Intravascular Hemolysis and Extracellular - jamanetwork.com
- Intravascular Hemolysis - an overview | ScienceDirect Topics - sciencedirect.com
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