What is a consequence of a chromosomal rearrangement moving the 'white' gene near heterochromatin?
Understand the Problem
The question is asking about the effects that occur when a chromosomal rearrangement causes the 'white' gene to be positioned near heterochromatin. This involves concepts from genetics concerning gene expression and regulation.
Answer
Transcriptional silencing in a stochastic pattern.
The final answer is transcriptional silencing in a stochastic pattern.
Answer for screen readers
The final answer is transcriptional silencing in a stochastic pattern.
More Information
Position-effect variegation (PEV) occurs when chromosomal rearrangements relocate a gene near heterochromatin, leading to stochastic patterns of gene silencing. This occurs because the spread of heterochromatin packaging from its boundary into the adjacent euchromatin regions can turn off genes that would normally be expressed.
Tips
A common mistake is assuming the silencing is uniform rather than stochastic. The effect is variable and often leads to mosaic expression in tissues.
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