Match the following drugs with their functions: Benserazide | Causes potential hepatotoxicity; Carbidopa | COMT inhibitor used alongside L-dopa; Tolcapone | Inhibits peripheral dop... Match the following drugs with their functions: Benserazide | Causes potential hepatotoxicity; Carbidopa | COMT inhibitor used alongside L-dopa; Tolcapone | Inhibits peripheral dopa decarboxylase; Entacapone | Selectively reduces peripheral dopamine formation.
Understand the Problem
The question is asking to match specific drugs with their respective functions. Each drug is listed with a function, and we need to identify which function corresponds to which drug based on pharmacological knowledge.
Answer
Benserazide - Inhibits peripheral dopa decarboxylase; Carbidopa - Inhibits peripheral dopa decarboxylase; Tolcapone - COMT inhibitor; Entacapone - COMT inhibitor.
Benserazide inhibits peripheral dopa decarboxylase, Carbidopa inhibits peripheral dopa decarboxylase, Tolcapone is a COMT inhibitor used alongside L-dopa, Entacapone is a COMT inhibitor.
Answer for screen readers
Benserazide inhibits peripheral dopa decarboxylase, Carbidopa inhibits peripheral dopa decarboxylase, Tolcapone is a COMT inhibitor used alongside L-dopa, Entacapone is a COMT inhibitor.
More Information
Tolcapone and entacapone are primarily used to inhibit the breakdown of levodopa, making it more effective for Parkinson's patients. Carbidopa and benserazide help in ensuring that more levodopa reaches the brain by inhibiting its peripheral conversion.
Tips
A common mistake is confusing the roles of COMT inhibitors and dopa decarboxylase inhibitors. COMT inhibitors like tolcapone and entacapone prevent levodopa breakdown, while dopa decarboxylase inhibitors like carbidopa and benserazide keep more levodopa available to enter the central nervous system.
Sources
- Parkinson's disease: etiopathogenesis and treatment - jnnp.bmj.com
- COMTIs and Tolcapone in Parkinson's Disease - researchgate.net
- Stalevo Drug Label - accessdata.fda.gov
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