In welchem Schritt wird Cholesterin an prä-beta-HDL angelegt?
Understand the Problem
Die Frage fragt danach, in welchem Schritt Cholesterin an prä-beta-HDL angelegt wird. Dies bezieht sich auf den Lipidstoffwechsel und die Rolle von HDL im Transport von Cholesterin.
Answer
Unesterified cholesterol is incorporated into pre-beta HDL before esterification by LCAT.
Unesterified cholesterol from cells is incorporated into pre-beta HDL, providing substrate for esterification by lecithin:cholesterol acyltransferase (LCAT).
Answer for screen readers
Unesterified cholesterol from cells is incorporated into pre-beta HDL, providing substrate for esterification by lecithin:cholesterol acyltransferase (LCAT).
More Information
Cholesterol is initially incorporated in its unesterified form, which is then esterified, allowing pre-beta HDL to transform and mature in its role in lipid transport.
Tips
Ensure understanding of the role of lecithin:cholesterol acyltransferase (LCAT) in cholesterol metabolism.
Sources
- Prebeta-1 HDL in plasma of normolipidemic individuals - PubMed - pubmed.ncbi.nlm.nih.gov
