In Myasthenia Gravis, which component of the neuromuscular junction is primarily affected by the autoimmune response?
Understand the Problem
The question is asking which specific part of the neuromuscular junction is impacted by the autoimmune response in Myasthenia Gravis. This is a medical topic related to immunology and neurology.
Answer
acetylcholine receptor (AChR)
The final answer is the acetylcholine receptor (AChR)
Answer for screen readers
The final answer is the acetylcholine receptor (AChR)
More Information
In Myasthenia Gravis, the immune system creates antibodies that target the acetylcholine receptors (AChR) located on the muscle side of the neuromuscular junction. This impairs signal transmission from nerve to muscle, leading to muscle weakness.
Tips
A common mistake is confusing the presynaptic and postsynaptic components of the neuromuscular junction. Myasthenia Gravis affects the postsynaptic acetylcholine receptors.
Sources
- Myasthenia gravis - an overview | ScienceDirect Topics - sciencedirect.com
- Myasthenia Gravis | National Institute of Neurological Disorders and Stroke - ninds.nih.gov
- Myasthenia Gravis: Practice Essentials, Background, Anatomy - emedicine.medscape.com
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