How does the structure of the glomerular basement membrane contribute to the formation of filtrate in Bowman's capsule?
Understand the Problem
The question is asking about the role of the glomerular basement membrane (GBM) structure in the kidney's filtration process. Specifically, it wants to know how the GBM's structure helps in forming filtrate within Bowman's capsule.
Answer
The GBM filters blood based on size and charge, retaining large proteins while allowing smaller molecules to pass into the filtrate.
The glomerular basement membrane (GBM) is a selectively permeable extracellular matrix that separates blood in the capillaries from filtrate in Bowman's capsule. It acts as a filter based on size and charge, preventing large proteins and negatively charged molecules from passing through, ensuring that essential proteins remain in the blood while allowing water, ions, and small molecules to pass into the filtrate.
Answer for screen readers
The glomerular basement membrane (GBM) is a selectively permeable extracellular matrix that separates blood in the capillaries from filtrate in Bowman's capsule. It acts as a filter based on size and charge, preventing large proteins and negatively charged molecules from passing through, ensuring that essential proteins remain in the blood while allowing water, ions, and small molecules to pass into the filtrate.
More Information
The GBM's structure is composed of a network of collagen, laminin, and other proteins that create a mesh-like barrier. This meshwork restricts the passage of molecules based on their size and electrical charge.
Tips
A common mistake is thinking only about size when considering filtration. The GBM also uses charge to filter.
Sources
- Glomerular filtration (glomerulus) | Renal physiology (article) - khanacademy.org
- The Glomerular Basement Membrane - PMC - pmc.ncbi.nlm.nih.gov
- Glomerular Filtration Barrier - an overview | ScienceDirect Topics - sciencedirect.com
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