A patient presents with hepatic impairment and a Child-Pugh score of 7. What general recommendation for dosage adjustments should be considered for medications that are primarily m... A patient presents with hepatic impairment and a Child-Pugh score of 7. What general recommendation for dosage adjustments should be considered for medications that are primarily metabolized by the liver?
Understand the Problem
The question is asking for the appropriate dosage adjustment recommendations for a patient with hepatic impairment based on their Child-Pugh score. It is specifically focusing on how medications that are primarily metabolized by the liver should be managed in this context.
Answer
Consider dose reduction for medications in Child-Pugh Class B.
For patients with a Child-Pugh score of 7 (Class B), a general recommendation is to consider dose reduction for medications primarily metabolized by the liver due to impaired clearance.
Answer for screen readers
For patients with a Child-Pugh score of 7 (Class B), a general recommendation is to consider dose reduction for medications primarily metabolized by the liver due to impaired clearance.
More Information
The Child-Pugh score is commonly used to assess liver disease severity. A score of 5-6 corresponds to Class A (mild), 7-9 to Class B (moderate), and 10-15 to Class C (severe). In general, the higher the score, the greater the need for dosage adjustments.
Tips
A common mistake is not adjusting doses which can lead to toxicity. Ensure to check drug-specific recommendations.
Sources
- Calculating and using the Child-Pugh score - sps.nhs.uk
- Drug Considerations for Medication Therapy in Cirrhosis - uspharmacist.com
- Pharmacokinetics in Patients with Impaired Hepatic Function - FDA - fda.gov
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