Normal vascular Growth Quiz
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Questions and Answers

What is the process called when vascularity increases in a tissue due to increased metabolism?

  • Vascular reconstruction
  • Angiogenesis (correct)
  • Tissue repair
  • Neovascularization
  • In which type of tissue does angiogenesis occur more slowly?

  • New growth tissue
  • Cancerous tissue
  • Old, well-established tissues (correct)
  • All tissues
  • What is the time required for long-term regulation of angiogenesis?

  • A few days in the neonate
  • Neither option
  • Both options (correct)
  • As long as months in older adults
  • What is the final degree of response to angiogenesis like in younger tissues compared to older tissues?

    <p>Better in younger tissues</p> Signup and view all the answers

    What is one example of increased vascularity in tissues due to low atmospheric oxygen?

    <p>Increased vascularity in animals at high altitudes</p> Signup and view all the answers

    What effect does excess oxygen have on vascular growth in premature babies?

    <p>Cessation of new vascular growth</p> Signup and view all the answers

    Which of the following factors is NOT involved in the formation of new blood vessels?

    <p>Angiogenin</p> Signup and view all the answers

    What is the condition called when retinal vessels grow out from the retina into the eye's vitreous humor, eventually causing blindness?

    <p>Retrolental fibroplasia</p> Signup and view all the answers

    What is the first step in angiogenesis?

    <p>Dissolution of the basement membrane of the endothelial cells</p> Signup and view all the answers

    What is the goal of tissue repair?

    <p>To restore normal function with native parenchymal and connective tissue</p> Signup and view all the answers

    Which cells contribute to the restoration of damaged tissues during tissue repair?

    <p>All of the above</p> Signup and view all the answers

    What is the process of new blood vessel development from existing vessels called?

    <p>Angiogenesis</p> Signup and view all the answers

    What is the final step in angiogenesis?

    <p>Recruitment of periendothelial cells</p> Signup and view all the answers

    Which of the following is a key factor in the process of angiogenesis?

    <p>Formation of the vascular lumen</p> Signup and view all the answers

    What role do fibroblast growth factors (FGFs) play in angiogenesis?

    <p>Stimulate the proliferation of endothelial cells</p> Signup and view all the answers

    What are angiopoietins 1 and 2 (Ang 1 and Ang 2) responsible for in angiogenesis?

    <p>Playing a role in angiogenesis and vascular maturation</p> Signup and view all the answers

    What is the role of vascular endothelial growth factors (VEGFs) in angiogenesis?

    <p>Stimulate migration and proliferation of endothelial cells</p> Signup and view all the answers

    What is the main reason why solid tumors need to induce angiogenesis?

    <p>To ensure the supply of oxygen and nutrients</p> Signup and view all the answers

    What are the sources of pro-angiogenic factors in angiogenesis?

    <p>All of the above</p> Signup and view all the answers

    What alters the production of pro-angiogenic factors in angiogenesis?

    <p>All of the above</p> Signup and view all the answers

    Which of the following is a characteristic of controlled neovascularization?

    <p>Formation of new blood vessels in wound healing</p> Signup and view all the answers

    What happens when oxygen levels are low in a cell?

    <p>HIF binds to EPO and other genes</p> Signup and view all the answers

    Which molecule is a potent inhibitor of endothelial cell proliferation and migration?

    <p>Endostatin</p> Signup and view all the answers

    Which disease is characterized by tumors in multiple organs, including the brain, spinal cord, eyes, and kidneys?

    <p>Von Hippel-Lindau disease</p> Signup and view all the answers

    What is the clinical significance of coronary collaterals in myocardial infarction?

    <p>They have no clinical relevance</p> Signup and view all the answers

    Do new blood vessels form in the heart after a myocardial infarction?

    <p>Yes, through granulation scar formation</p> Signup and view all the answers

    What is the role of capillary density in myocardial infarction?

    <p>It is not affected by myocardial infarction</p> Signup and view all the answers

    Which process is NOT associated with controlled neovascularization?

    <p>Retinopathy</p> Signup and view all the answers

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