Angiogenesis and Neovessel Formation

Vasculogenesis is driven by local ECs.

Diabetic foot ulcer is a result of enhanced angiogenesis.

VEGF-A stimulates lymphangiogenesis.

Endothelial cells are responsible for reestablishing vascular support in response to stimuli such as a wound.

Critical limb ischemia occurs when blood flow to limbs is increased.

Endothelial cells make up the entirety of the blood vessel wall in all types of blood vessels.

Nitric oxide is produced by Vascular Smooth Muscle Cells (VSMCs).

Endothelial cells are omnipotent: they have the same structure and functional properties regardless of the organ or tissue they are found in.

Endothelial cells only allow essential nutrients and oxygen to pass through their selectively permeable barrier.

Endothelial cells can proliferate and migrate to form new blood vessels in response to tissue injury or increased oxygen and nutrient demand.

Myosin light chain dephosphorylation is achieved through calcium pumping back into SR by SERCA and calcium extrusion out of the cell by PMCA and NCX.

Reducing MLCK activity is a mechanism for myosin light chain dephosphorylation.

Rho/ROCK Signaling is involved in the pathogenesis of Atherosclerosis.

Vascular Endothelial Cells form a multi-cellular layer lining the lumen of all blood vessels.

Endothelial Cells account for about 5 kg of an adult human body.