Eukaryotic Cell Cycle Quiz

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Questions and Answers

What roles do CDKs and cyclins play in the eukaryotic cell cycle?

  • They do not affect the duration of any cell cycle phase.
  • They are involved in cell cycle regulation by phosphorylating proteins. (correct)
  • They are only responsible for DNA replication.
  • They play no role in cellular processes.

The restriction point is critical for ensuring a cell is ready to enter DNA synthesis.

True (A)

What is the primary function of E2F in the eukaryotic cell cycle?

To help the cell overcome the restriction point.

During the transition from G1 to S phase, the cell checks for the presence of ______ necessary for DNA replication.

<p>specific proteins</p> Signup and view all the answers

Which of the following events occurs during the G2 to M phase transition?

<p>DNA synthesis completion is verified. (C)</p> Signup and view all the answers

Surveillance mechanisms in the cell cycle are designed to promote unregulated cell growth.

<p>False (B)</p> Signup and view all the answers

Match the following cell cycle components with their descriptions:

<p>CDKs = Enzymes that regulate the cell cycle through phosphorylation Cyclins = Proteins that activate CDKs APC/C = Complex that triggers the exit from M phase CKIs = Inhibitors of CDKs</p> Signup and view all the answers

If error-free DNA synthesis is not completed, a cell may die through ______ or develop cancer.

<p>apoptosis</p> Signup and view all the answers

Flashcards

CDK

Cyclin-dependent kinases are enzymes that regulate the cell cycle by phosphorylating target proteins.

Cyclin

A protein that activates a cyclin-dependent kinase (CDK).

Start/Restriction point

A critical point in the G1 phase where the cell commits to entering the cell cycle.

APC/C

Anaphase-promoting complex/cyclosome is a protein complex that triggers the transition from metaphase to anaphase in mitosis.

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SCF

A protein complex that plays a role in regulating the cell cycle, specifically targeting proteins for degradation and plays important roles in the cell cycle and development.

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CKI

Cyclin-dependent kinase inhibitors are proteins that regulate the cell cycle by inhibiting the activities of cyclin-CDK complexes.

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Mitogen

A substance that stimulates cell division.

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E2F

A transcription factor that promotes the expression of genes required for DNA replication and the cell cycle.

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G1 to S Phase Transition

The point at which the cell decides to enter DNA replication or not.

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G2 to M Phase Transition

The transition from G2 to M phase is triggered by a series of events controlled by specific protein interactions.

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Chromosomal Segregation

The process of separating sister chromatids during mitosis or meiosis.

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Cell Cycle Exit

The process through which the cell cycle stops. The processes ensuring apoptosis are triggered.

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Surveillance Mechanisms

Cellular monitoring systems that ensure accuracy of the cell cycle events. They trigger cell cycle arrest when errors are detected.

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Study Notes

Eukaryotic Cell Cycle

  • The eukaryotic cell cycle, though appearing simple (G1, S, G2, M), is complex and highly regulated
  • Specific proteins, cellular readiness, and completion of previous stages are required for each phase
  • DNA synthesis must be error-free during the S to G2 transition
  • Surveillance mechanisms arrest cell growth if DNA synthesis is not accurate or errors present
  • Apoptosis or mutations can lead to cancer development

Cell Cycle Regulation

  • CDKs (Cyclin-Dependent Kinases) and cyclins regulate progression through the cell cycle
  • Cyclin degradation and CDK phosphorylation are critical for progression through different phases
  • E2F plays a role in overcoming the restriction point (G1 to S)
  • Specific events dictate the transition among phases, including G1 to S, G2 to M, entry to mitosis, chromosomal segregation, and exit from M
  • Surveillance mechanisms prevent inappropriate cell cycle progression

Learning Objectives

  • Define terms (CDKs, cyclins, Start/Restriction point, APC/C, SCF, CKIs, and mitogens)
  • Describe the role of CDK phosphorylation and cyclin degradation in cell cycle progression
  • Explain the role of E2F in overcoming the restriction point
  • Discuss events dictating transitions (G1 to S, G2 to M)
  • Explain surveillance mechanisms preventing inappropriate progression of the eukaryotic cell cycle

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