Eukaryotic Cell Cycle (BIOL 374) PDF

Burman University, BIOL 374 Cellular Biology, Eukaryotic Cell Cycle Eukaryotic Cell Cycle Learning Objectives: After completing this module, you will be able to 1. Define the following terms: CDKs, cyclins, Start/Restriction point, APC/C, SCF, CKIs and mitogens. 2. Describe the role o...

Burman University, BIOL 374 Cellular Biology, Eukaryotic Cell Cycle Eukaryotic Cell Cycle Learning Objectives: After completing this module, you will be able to 1. Define the following terms: CDKs, cyclins, Start/Restriction point, APC/C, SCF, CKIs and mitogens. 2. Describe the role of CDK phosphorylation and cyclin degradation in the progression through the different stages of the cell cycle. 3. Explain the role of E2F in overcoming the restriction point. 4. Discuss the events that dictate the transition of cell cycle phases: G1 to S, G2 to M (entry to mitosis), chromosomal segregation and exit from M. 5. Explain the surveillance mechanisms that prevent inappropriate progression of the eukaryotic cell cycle. Text: Lodish et al. (2021), Ch. 19 Verse: For everything there is a season, and a time for every matter under heaven: a time to be born, and a time to die; a time to plant, and a time to pluck up what is planted; a time to kill, and a time to heal; a time to break down, and a time to build up; a time to weep, and a time to laugh; a time to mourn, and a time to dance; a time to cast away stones, and a time to gather stones together; a time to embrace, and a time to refrain from embracing; a time to seek, and a time to lose; a time to keep, and a time to cast away; a time to tear, and a time to sew; a time to keep silence, and a time to speak; a time to love, and a time to hate; a time for war, and a time for peace. Ecclesiastes 3:1-8 (ESV) There is a time for everything… The eukaryotic cell cycle appears simple – G1, S, G2 and M phases (as we learnt in our introductory biology courses). However, a closer look at all the events of the cell cycle indicates that this process is very complex and highly regulated. To enter a cell cycle phase requires specific protein products to be present, a cellular state of readiness, and the completion of the previous stage. For example, in the S to G2 transition, error-free DNA synthesis must be completed otherwise surveillance mechanisms are put into place to arrest the growth of the aberrant cell. The cell will either die by apoptosis, or a mutation(s) may lead to the development of cancer with uncontrolled cell growth. Like the changing of the seasons, God has placed life lessons, events, persons, cellular biology exams, etc, in our lives to guide our progression on this earth. While these may not be apparent now, I have looked back at many things in my life that impeded, or advanced, my progress through the years. And I thank God for all of life’s transitions. LW2024