X-linked Agammaglobulinemia and Common Variable Immunodeficiency
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Questions and Answers

Which immune deficiency disorder is characterized by the inability of Pro-B cells to differentiate into Pre-B cells due to lack of tyrosine kinase?

  • Hypogammaglobulinemia
  • Common variable immunodeficiency
  • X-linked agammaglobulinemia(Bruton’s) (correct)
  • Isolated IgA deficiency

Which immune deficiency disorder is characterized by low levels of antibodies in the blood?

  • Isolated IgA deficiency (correct)
  • Common variable immunodeficiency
  • X-linked agammaglobulinemia(Bruton’s)
  • Hyper IgM syndrome

Which immune deficiency disorder shows a normal level of antibodies and lymphocytes but reduced IgA in serum?

  • X-linked agammaglobulinemia(Bruton’s)
  • Common variable immunodeficiency
  • Isolated IgA deficiency (correct)
  • Hyper IgM syndrome

Why can a test for celiac disease show a false negative result in a person with IgA deficiency?

<p>Low IgA level in the blood serum (A)</p> Signup and view all the answers

Which immune deficiency disorder is associated with life-threatening anaphylaxis post blood transfusion due to the recognition of transfused IgA as foreign?

<p>Isolated IgA deficiency (B)</p> Signup and view all the answers

What is the specific defect in Hyper IgM syndrome that leads to the inability of helper T cells to activate B cells and macrophages?

<p>CD40L deficiency (B)</p> Signup and view all the answers

Which germ layer gives rise to connective tissue, ovaries, testes, spleen, heart, blood, and kidneys?

<p>Mesoderm (D)</p> Signup and view all the answers

At what stage does the embryonic heart begin to beat?

<p>Day 21 (C)</p> Signup and view all the answers

What structure anchors the chorionic sac to the endometrium?

<p>Cytotrophoblast shell (A)</p> Signup and view all the answers

Which zone of spinal cord development develops into white matter tracks?

<p>Outer marginal zone (B)</p> Signup and view all the answers

When is maternal-fetal circulation needed due to the diffusion of nutrients being insufficient?

<p>Week 4 (B)</p> Signup and view all the answers

What is the name of the structure present in week 3 that is composed of an extraembryonic mesenchymal core surrounded by cytotrophoblasts and syncytiotrophoblast?

<p>Tertiary chorionic villi (B)</p> Signup and view all the answers

What is the structure that becomes the anus?

<p>Cloacal membrane (D)</p> Signup and view all the answers

What forms the neural tube?

<p>Neural folds/grooves (C)</p> Signup and view all the answers

What is the function of the allantois in early development?

<p>Bladder development (C)</p> Signup and view all the answers

Which germ layer gives rise to the CNS, PNS, hair, teeth, and neural crest cells?

<p>Ectoderm (B)</p> Signup and view all the answers

What structure separates the abdomen and the thoracic cavity?

<p>Septum transversum (B)</p> Signup and view all the answers

What is the significance of the closure of neuropores?

<p>Marks the end of neurulation (D)</p> Signup and view all the answers

Where is the cardiogenic mesoderm located?

<p>Anterior and lateral to the notochordal process (A)</p> Signup and view all the answers

What happens with the neural crest cells during neural folding?

<p>They migrate and can become part of PNS (B)</p> Signup and view all the answers

What structure out pouches from the causal wall of the umbilical vesicle and into the connecting stalk?

<p>Urachus (A)</p> Signup and view all the answers

What is the first formation in neurulation?

<p>The neural plate (day 19) (B)</p> Signup and view all the answers

What is the known prognosis for Hyper IgM?

<p>Not good prognosis (A)</p> Signup and view all the answers

What is the main biology feature of DiGeorge syndrome?

<p>T-cell deficiency (B)</p> Signup and view all the answers

How is 22q11 deletion syndrome diagnosed?

<p>In childhood due to complex cardiac abnormalities (D)</p> Signup and view all the answers

What is the key feature of SCID (Severe Combined Immunodeficiency)?

<p>Deficiency in cytokine receptors (A)</p> Signup and view all the answers

What is the genetic defect associated with Hereditary Angioedema?

<p>C2 deficiency (C)</p> Signup and view all the answers

Which immunodeficiency disorder involves accumulation of toxic deoxyadenosine?

<p>SCID (B)</p> Signup and view all the answers

What is the treatment for Hereditary Angioedema?

<p>C1 inhibitor from blood products (A)</p> Signup and view all the answers

What is the major feature of Otitis Media with Effusion (OME)?

<p>Fluid buildup leading to hearing loss (D)</p> Signup and view all the answers

What are the typical findings of Acute Otitis Media (AOM) in the tympanic membrane?

<p>Fluid, bulging, ear pain (C)</p> Signup and view all the answers

Why does Otitis Media have a higher incidence in children aged 0-5?

<p>Eustachian tube anatomy in young children (C)</p> Signup and view all the answers

Which pathogen is commonly associated with causing meningitis and sepsis in children?

<p>Haemophilus influenzae (C)</p> Signup and view all the answers

What is the unique virulence factor of gram-negative pathogens that is released when they die?

<p>Lipid A chains (A)</p> Signup and view all the answers

Which pathogen is commonly resistant to beta-lactam drugs such as penicillin and amoxicillin?

<p>Moraxella catarrhalis (B)</p> Signup and view all the answers

What is the main function of the prechordal plate in embryology?

<p>Organizing the structure of the head (B)</p> Signup and view all the answers

Which pathogen contributes to 90% of the microbiota of the skin?

<p>Staphylococcus aureus (D)</p> Signup and view all the answers

'Pyocyanin' triggers free radical accumulation and causes tissue damage in infections caused by which pathogen?

<p>Pseudomonas aeruginosa (A)</p> Signup and view all the answers

'Otopathogens' are pathogens that increase the chance of ear infections. Which pathogen is considered an 'otopathogen'?

<p>Moraxella catarrhalis (A)</p> Signup and view all the answers

What is a common cause of otitis externa?

<p>Pseudomonas aeruginosa (A)</p> Signup and view all the answers

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