Podcast
Questions and Answers
What is the incidence of Common Variable Immunodeficiency (CVID) worldwide?
What is the incidence of Common Variable Immunodeficiency (CVID) worldwide?
1:25,000-50,000
What are the genetic mutations associated with Common Variable Immunodeficiency (CVID)?
What are the genetic mutations associated with Common Variable Immunodeficiency (CVID)?
Mutations in ICOS, CD19, BAFF-R, TNFRSF13B gene sets
What is the main cause of Common Variable Immunodeficiency (CVID) in 90% of cases?
What is the main cause of Common Variable Immunodeficiency (CVID) in 90% of cases?
Currently unknown
What is the prevalence of Common Variable Immunodeficiency (CVID) in males compared to females?
What is the prevalence of Common Variable Immunodeficiency (CVID) in males compared to females?
What is the main genetic risk factor associated with Common Variable Immunodeficiency (CVID)?
What is the main genetic risk factor associated with Common Variable Immunodeficiency (CVID)?
Which gene mutation affects the B cell survival, maturation, and antibody production in Common Variable Immunodeficiency (CVID)?
Which gene mutation affects the B cell survival, maturation, and antibody production in Common Variable Immunodeficiency (CVID)?
What is an example of a primary immunodeficiency characterized by a combined T- and B-cell defect?
What is an example of a primary immunodeficiency characterized by a combined T- and B-cell defect?
Which gene deficiency is associated with the most common autosomal recessive SCID?
Which gene deficiency is associated with the most common autosomal recessive SCID?
What are the manifestations of SCID in infants?
What are the manifestations of SCID in infants?
Name a low virulence organism that can cause severe disease in individuals with SCID.
Name a low virulence organism that can cause severe disease in individuals with SCID.
What type of genetic mutation in the CD19 gene can lead to B-cell defects?
What type of genetic mutation in the CD19 gene can lead to B-cell defects?
What is the genetic mutation associated with X-linked severe combined immunodeficiency (X-SCID)?
What is the genetic mutation associated with X-linked severe combined immunodeficiency (X-SCID)?
What is the consequence of defects in genes responsible for V(D)J recombination of T cell receptor and B cell receptor?
What is the consequence of defects in genes responsible for V(D)J recombination of T cell receptor and B cell receptor?
What syndrome is characterized by defects in genes that allow rearrangement of T cell receptor and B cell receptor?
What syndrome is characterized by defects in genes that allow rearrangement of T cell receptor and B cell receptor?
In which immunodeficiency disorder are T cells and B cells produced but not functional and limited in number?
In which immunodeficiency disorder are T cells and B cells produced but not functional and limited in number?
What is the main treatment for severe combined immunodeficiency (SCID) in infants?
What is the main treatment for severe combined immunodeficiency (SCID) in infants?
What is the consequence of a mutation in the common gamma chain (É£c) of cytokine receptors for cytokines?
What is the consequence of a mutation in the common gamma chain (É£c) of cytokine receptors for cytokines?
What is the reason for washing the gel extensively in the process of identifying immunoglobulin components?
What is the reason for washing the gel extensively in the process of identifying immunoglobulin components?
What is the significance of the narrow band or 'M protein' in the electrophoresis of serum proteins?
What is the significance of the narrow band or 'M protein' in the electrophoresis of serum proteins?
Which two processes during B cell development increase the risk of malignant transformation?
Which two processes during B cell development increase the risk of malignant transformation?
Why are B cell malignancies more common than T cell malignancies?
Why are B cell malignancies more common than T cell malignancies?
What is the significance of class switch recombination in B cells?
What is the significance of class switch recombination in B cells?
Why do mature B cells divide in secondary lymphoid tissue?
Why do mature B cells divide in secondary lymphoid tissue?
Explain one mechanism by which cancer cells avoid immune attack.
Explain one mechanism by which cancer cells avoid immune attack.
Describe the role of NK cells in avoiding immune attack by cancer cells.
Describe the role of NK cells in avoiding immune attack by cancer cells.
How do cancer cells create a physical barrier to immune cells?
How do cancer cells create a physical barrier to immune cells?
Explain the concept of antigenic modulation in immune evasion by cancer cells.
Explain the concept of antigenic modulation in immune evasion by cancer cells.
Discuss the relationship between chronic inflammation and cancer risk.
Discuss the relationship between chronic inflammation and cancer risk.
Explain the significance of immune surveillance in cancer prevention.
Explain the significance of immune surveillance in cancer prevention.
Explain how cancer cells evade the immune system using the PD-L1/PD-1 pathway.
Explain how cancer cells evade the immune system using the PD-L1/PD-1 pathway.
Describe the role of immune checkpoint proteins CTLA-4 and PD-1 in cancer immunotherapy.
Describe the role of immune checkpoint proteins CTLA-4 and PD-1 in cancer immunotherapy.
How do cancer cells utilize TGF-β, IL-10, and IDO to inhibit T cells?
How do cancer cells utilize TGF-β, IL-10, and IDO to inhibit T cells?
Explain the mechanism of immune checkpoint blockade therapy in cancer treatment.
Explain the mechanism of immune checkpoint blockade therapy in cancer treatment.
How does adoptive cellular therapy contribute to cancer treatment?
How does adoptive cellular therapy contribute to cancer treatment?
What is the significance of immune surveillance in cancer development?
What is the significance of immune surveillance in cancer development?
