12 Questions
What is the main reason behind the lack of B-cells in X-linked agammaglobulinemia (Bruton’s)?
Inability of pro-B cells to differentiate into pre-B cells due to tyrosine kinase deficiency
Which condition is characterized by hypogammaglobulinemia, reduced lymphocytes, and decreased T-cell activity?
Common variable immunodeficiency
What is a common symptom associated with Isolated IgA deficiency?
Otitis media
Why can a celiac test result show a false negative in a patient with IgA deficiency?
Low IgA levels in blood serum affect the test accuracy
What is the primary biological defect in Hyper IgM syndrome?
Deficiency or lack of function of CD40L
Which immune deficiency can result in life-threatening anaphylaxis post blood transfusion due to recognition of transfused IgA as foreign?
Isolated IgA deficiency
Which of the following is true about hyper IgM syndrome?
It is an autosomal recessive disorder that primarily affects males
What is the prognosis for hyper IgM syndrome?
Poor prognosis
DiGeorge syndrome is also known as:
22q11 deletion syndrome
What is the primary biological cause of DiGeorge syndrome?
Abnormal development of the 3rd and 4th pharyngeal pouches, leading to a small thymus and T-cell deficiency
What is the primary immunodeficiency associated with severe combined immunodeficiency (SCID)?
Mutation in cytokine receptors or the RAG gene, leading to a lack of T lymphocytes and NK cells
Which of the following is an example of an innate immunodeficiency?
Hereditary angioedema
Learn about X-linked agammaglobulinemia (Bruton’s) which mainly affects males, leading to underdeveloped B-cells and reduced antibody production. Explore the treatment with IV immunoglobulins and the uncommon Common Variable Immunodeficiency characterized by hypogammaglobulinemia and reduced lymphocytes.
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