5 Toxin Cases

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Questions and Answers

In the case of the 12-year-old Rocky Mountain Horse presenting with reduced appetite, weight loss, and crusting lesions on lightly pigmented skin, which bloodwork finding is MOST directly indicative of the primary underlying cause of secondary photosensitization?

  • Increased anion gap and sodium potassium ratio
  • Elevated aspartate transaminase (AST) and alkaline phosphatase (ALP) (correct)
  • Mildly elevated creatinine and urea nitrogen
  • Decreased potassium and chloride levels

Considering the clinical presentation and bloodwork results of the 12-year-old Rocky Mountain Horse, which of the following pathophysiological mechanisms BEST explains the development of secondary photosensitization in this case?

  • Impaired hepatic excretion of phylloerythrin resulting in its deposition in superficial skin layers. (correct)
  • Direct cytotoxic effect of plant toxins on melanocytes causing localized skin necrosis and inflammation.
  • Increased production of protoporphyrinogen oxidase leading to porphyrin accumulation in erythrocytes.
  • Autoimmune-mediated destruction of dermal collagen and elastin, increasing skin sensitivity to UV radiation.

Given the diagnosis of primary hepatic disease and secondary photosensitization in the 12-year-old Rocky Mountain Horse, which of the following management strategies is the MOST crucial for long-term prognosis?

  • Initiating corticosteroid therapy to reduce dermal inflammation and crusting.
  • Implementing strict stall confinement and sun avoidance measures.
  • Administering broad-spectrum antibiotics to prevent secondary skin infections.
  • Identifying and eliminating the hepatotoxic plant source from the horse's environment and diet. (correct)

In the case of the 18-year-old Thoroughbred mare with colic and reflux, the suspicion of cantharidin toxicity is raised due to the alfalfa hay consumption. Which component of alfalfa hay is MOST directly associated with cantharidin contamination?

<p>Blister beetles that are inadvertently harvested with alfalfa. (D)</p> Signup and view all the answers

Considering the clinical signs of colic and foul-smelling reflux in the 18-year-old Thoroughbred mare, and the suspicion of cantharidin toxicity, what is the MOST appropriate initial diagnostic test to confirm cantharidin exposure?

<p>Urinalysis to detect cantharidin excretion. (D)</p> Signup and view all the answers

In the 18-year-old Thoroughbred mare with suspected cantharidin toxicity, the passage of a nasogastric tube and collection of 15 liters of foul-smelling reflux is a critical step in management. What is the PRIMARY therapeutic benefit of nasogastric intubation and refluxing in this scenario?

<p>To relieve gastric distension and reduce the risk of gastric rupture. (C)</p> Signup and view all the answers

For the 18-year-old Quarter Horse gelding presenting with weight loss, a heart murmur, crackles, and jugular pulses, which pathophysiological mechanism is MOST consistent with the observed clinical signs?

<p>Mitral valve regurgitation causing left-sided congestive heart failure. (A)</p> Signup and view all the answers

Considering the history of another horse found dead and the clinical signs in the 18-year-old Quarter Horse gelding, ionophore toxicity is considered as a differential. What is the PRIMARY mechanism by which ionophores induce cardiac damage in horses?

<p>Disruption of mitochondrial function in cardiomyocytes leading to cellular necrosis. (C)</p> Signup and view all the answers

White snakeroot toxicity is also considered in the differential diagnosis for the 18-year-old Quarter Horse gelding. Which toxic principle in white snakeroot is responsible for cardiac and skeletal muscle damage in horses?

<p>Tremetone (D)</p> Signup and view all the answers

In the case of the 5-year-old Arabian gelding with anorexia in an overgrazed pasture, and the suspicion of red maple toxicity, which hematological finding is MOST directly associated with acute red maple leaf toxicity?

<p>Heinz body hemolytic anemia. (C)</p> Signup and view all the answers

The CBC of the 5-year-old Arabian gelding reveals a leukocytosis with a segmented neutrophilia and a mild left shift. While red maple toxicity primarily causes hemolytic anemia, what is the MOST likely explanation for the observed leukogram changes in this acutely ill horse?

<p>Stress leukogram secondary to pain and systemic illness. (C)</p> Signup and view all the answers

Considering the overgrazed pasture and stripped bark on trees in the 5-year-old Arabian gelding's environment, which of the following differential diagnoses, beyond red maple toxicity, should be MOST strongly considered in a horse presenting with anorexia and potential pica?

<p>Chronic parasitism and malnutrition (C)</p> Signup and view all the answers

To differentiate between red maple toxicity and other causes of anemia and anorexia in the 5-year-old Arabian gelding, which diagnostic approach would provide the MOST specific information regarding red maple exposure?

<p>Microscopic examination of a blood smear for Heinz bodies. (D)</p> Signup and view all the answers

In managing a horse with suspected red maple toxicity, beyond supportive care, what is the PRIMARY therapeutic goal aimed at mitigating the hemolytic effects of the toxin?

<p>Providing blood transfusions to replace lost red blood cells and improve oxygen carrying capacity. (A)</p> Signup and view all the answers

When comparing Red Maple and Pin Oak leaves, as depicted in the images, what is the MOST reliable morphological feature to differentiate Red Maple from Pin Oak leaves, especially considering potential leaf fragmentation or decomposition?

<p>The presence of sharply pointed lobes versus rounded lobes. (C)</p> Signup and view all the answers

Considering the long-term management of a horse that has recovered from red maple toxicity, what is the MOST critical preventative measure to minimize the risk of recurrence?

<p>Strategic pasture management to eliminate or restrict access to red maple trees, especially wilted leaves. (B)</p> Signup and view all the answers

In the context of equine toxicology, pyrrolizidine alkaloids are mentioned as a toxic principle. Although not directly implicated in these cases, which of the following plants is a well-known source of pyrrolizidine alkaloids and commonly causes chronic liver disease in horses?

<p>Tansy ragwort (<em>Senecio jacobaea</em>) (B)</p> Signup and view all the answers

Foxglove (Digitalis purpurea) was listed as an option for a toxic plant. While not the correct answer for the photosensitization case, what is the PRIMARY toxic effect of cardiac glycosides found in foxglove on equine physiology?

<p>Cardiotoxicity resulting in arrhythmias and heart failure. (C)</p> Signup and view all the answers

Considering the presented cases collectively, which of the following clinical signs is the MOST sensitive indicator of potential plant-based toxicosis in horses, warranting further investigation into environmental exposures?

<p>Sudden onset of anorexia or altered behavior. (C)</p> Signup and view all the answers

In managing equine toxicities, rapid identification of the toxic agent is crucial. Which of the following resources is MOST valuable for quickly identifying potential toxic plants based on visual characteristics and geographical location to aid in diagnosis?

<p>Online botanical databases and plant identification apps. (A)</p> Signup and view all the answers

Flashcards

Rocky Mountain Horse clinical signs

Characterized by reduced appetite and weight loss, lethargy, normal vital parameters, and crusting lesions on lightly pigmented areas.

Bloodwork findings in Rocky Mountain Horse

Elevated liver enzymes (AST, GGT, SDH), Icterus, and trace hemolysis

Primary liver disease in horses

Yes, primary hepatic disease is present, leading to secondary photosensitization.

Toxic plant for horses

Crotalaria, a plant, would be most consistent with induction of these abnormalities.

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Thoroughbred Mare clinical signs

Mare showing signs of colic, HR=60 bpm, RR = 40 BPM, T = 101.8 F, improved with flunixin meglumine, then colicky again; 15 L of foul smelling reflux.

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Mare diet

Mare is fed prairie and alfalfa hay and Alfalfa hay was harvested previous summer in July.

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Cantharidin toxicity

Important differential consideration based on symptoms and diet.

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Mare diagnostic tests

CBC and serum chemistry, urine test for cantharidin, electrolyte panel.

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Therapy needed for the mare

The mare is colicky and refluxing needing stomach decompression and intravenous fluids.

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Quarter Horse gelding clinical signs

Presents for weight loss; owner increased grain but cannot gain weight; horse has been a ranch horse for many years. Another horse on the farm was found dead in pasture 1 week previously.

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Quarter Horse gelding vital parameters

98.9 F; P = 72 BPM, Grade 5/6 holosystolic murmur, RR = 28 BrPM, Bilateral crackles present.

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Next steps for Quarter Horse

Extension agent to examine pasture, feed analysis, cardiac exam (ECG, echocardiogram).

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Differential considerations for Arabian gelding experiencing anorexia

Indiscriminant feed/forage ingestion and anemia could suggest red maple toxicity.

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Diagnosis establishment in Arabian gelding cases

Examine the property to determine if toxic plans are present and determine status of other horses in the area.

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Study Notes

Rocky Mountain Horse Case

  • 12-year-old Rocky Mountain Horse exhibited reduced appetite, weight loss, and lethargy.
  • The horse had a body condition score of 3/9.
  • Physical examination showed normal vital parameters: T = 99.7 F, P = 44 BPM, RR = 12 BrPM.
  • Dermatologic examination showed crusting lesions on lightly pigmented areas, including the white blaze and a lower limb white sock.
  • Bloodwork was initiated.
  • The horse likely has primary hepatic disease leading to secondary photosensitization.
  • Crotalaria plant is consistent with the abnormalities observed.

Thoroughbred Mare Case

  • 18-year-old Thoroughbred mare at K-State CVM showed signs of colic at LARC.
  • Initial examination revealed HR = 60 bpm, RR = 40 BPM, and T = 101.8 F.
  • Flunixin meglumine improved the mare’s condition temporarily.
  • The mare showed colic signs again after about 3 hours.
  • Reexamination with a nasogastric tube resulted in approximately 15 L of foul-smelling reflux.
  • The mare received IV fluids and was under hospital management.
  • Diet information is important, specifically if the mare consumed prairie hay and alfalfa hay harvested in July, which indicates third cutting hay in full bloom.
  • Cantharidin toxicity is an important consideration.
  • Diagnostics should include a complete blood count, serum chemistry analysis, and tests for electrolyte balance.
  • Urine should be tested for cantharidin, and other hay should be removed to avoid cantharidin toxicity
  • The mare was colicky and refluxing, requiring stomach decompression.
  • Surgery was indicated if the mare remained painful.
  • Continued decompression, IV fluids, and pain management are indicated.
  • Antibiotics are indicated if bloodwork suggests sepsis.
  • The mare was euthanized due to being uncomfortable, and the teaching horses were no longer fed alfalfa hay based on this incident.

Quarter Horse Gelding Case

  • 18-year-old Quarter Horse gelding presented for weight loss.
  • The owner had already increased the grain, but the horse still couldn’t gain weight.
  • The horse lived in a drylot, fed square bale hay with concentrate grain twice a day.
  • There was another horse found dead in the pasture one week prior.
  • The current patient was found lying down but improved after receiving flunixin meglumine.
  • The physical examination showed T = 98.9 F and P = 72 BPM.
  • A Grade 5/6 holosystolic murmur, PMI over the mitral valve, and jugular pulses were present.
  • RR = 28 BrPM, and bilateral crackles were detected diffusely in all lung fields.
  • The horse exhibited lethargy and poor appetite.
  • Colic examination was not likely indicated.
  • Consulting with an extension agent to examine the pasture (specifically looking for white snakeroot) is logical next step.
  • Feed analysis to rule out ionophore contamination is necessary.
  • A complete cardiac examination might be required to assess cardiac isoenzyme testing
  • This horse was in congestive heart failure.
  • Ionophore intoxication was suspected but unconfirmed and communicated to the client to prevent future incidents.

Arabian Gelding Case

  • 5-year-old Arabian gelding was examined for anorexia.
  • The horse lives in a pasture with 3 other horses and typically has a round bale of hay, but the manger is empty.
  • The pasture is overgrazed with stripped bark on trees.
  • Physical examination showed HR = 80 BPM, RR = 24 BrPM, and T = 101.3 F.
  • There should be concern about indiscriminate feed or forage ingestion.
  • Anemia could indicate red maple toxicity
  • Examine the property to identify toxic plants and evaluate the status of other horses to determine if they are affected.
  • The client mentioned fallen leaves from a tree as a concern.

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