Wound Healing Overview

<p>Specialized bone-forming tissue (D)</p> Signup and view all the answers

<p>Irregular arrangement of collagen bundles (D)</p> Signup and view all the answers

<p>Haematoma formation occurs (B)</p> Signup and view all the answers

<p>Increased polymorphonuclear leucocyte infiltration (C)</p> Signup and view all the answers

<p>Regeneration (D)</p> Signup and view all the answers

<p>Open Wound (A)</p> Signup and view all the answers

<p>Surface epithelium of the skin (D)</p> Signup and view all the answers

<p>Stable cells (D)</p> Signup and view all the answers

<p>Permanent cells (B)</p> Signup and view all the answers

<p>Type of cells in the damaged organ (C)</p> Signup and view all the answers

<p>Haematoma (B)</p> Signup and view all the answers

<p>Repair (A)</p> Signup and view all the answers

<p>It can cause persistent trauma. (C)</p> Signup and view all the answers

<p>It blocks cell proliferation. (A)</p> Signup and view all the answers

<p>Impaired circulation. (D)</p> Signup and view all the answers

<p>They delay wound healing. (B)</p> Signup and view all the answers

<p>Wound dehiscence. (B)</p> Signup and view all the answers

<p>It is associated with delayed wound healing. (A)</p> Signup and view all the answers

<p>They do not interfere when taken at usual doses. (D)</p> Signup and view all the answers

<p>Deficient scar formation. (D)</p> Signup and view all the answers

<p>Excessive hydration. (B)</p> Signup and view all the answers

<p>Inappropriate suture techniques. (C)</p> Signup and view all the answers

<p>Restoration of an intact epithelial surface and tensile strength of sub-epithelial tissue (A)</p> Signup and view all the answers

<p>Rapid cell apoptosis (B)</p> Signup and view all the answers

<p>To stimulate cell division and proliferation (B)</p> Signup and view all the answers

<p>Platelets (D)</p> Signup and view all the answers

<p>Wound contraction (B)</p> Signup and view all the answers

<p>Presence of inflammatory cells (C)</p> Signup and view all the answers

<p>Wound contraction (B)</p> Signup and view all the answers

<p>Collagenization and progressive acquisition of wound strength (A)</p> Signup and view all the answers

<p>A large ugly scar is formed (A)</p> Signup and view all the answers

<p>Regeneration (C)</p> Signup and view all the answers

<p>They assist in reducing the size of the wound through contraction. (B)</p> Signup and view all the answers

<p>Fibrin clot forms and undergoes dehydration. (B)</p> Signup and view all the answers

<p>Healing by primary union (D)</p> Signup and view all the answers

<p>5 days (B)</p> Signup and view all the answers

<p>Scar tissue forms and collagen continues to accumulate. (C)</p> Signup and view all the answers

<p>It has an intact epidermal covering with dense connective tissue. (C)</p> Signup and view all the answers

<p>Epithelial cell proliferation and basal cell thickening. (B)</p> Signup and view all the answers

<p>Basal cells proliferate and epithelial cells migrate and deposit basement membrane components. (A)</p> Signup and view all the answers

<p>It is used for heavily contaminated or irregular wounds. (D)</p> Signup and view all the answers

<p>Optimal proliferation of blood vessels and collagen fibers bridging the incision. (B)</p> Signup and view all the answers

The body's process of replacing destroyed tissue with living tissue.

A breach or defect in living tissue caused by injury, accompanied by inflammation.

A wound where the skin is intact, but underlying tissues are damaged. Examples include contusions, hematomas, and pressure ulcers.

A wound where the skin is broken or cracked, exposing underlying tissue.

Wound healing where lost tissue is replaced by similar tissue.

Wound healing using granulation tissue forming scar tissue to replace lost tissue.

Cells that frequently divide and regenerate well, found in the skin, gut, urinary tract and blood cells.

Non-dividing cells, if lost, they cannot be replaced. Examples include neurons in the brain and specialized cardiac muscle cells.

The primary goals of wound healing are to restore the skin surface and the strength of the underlying tissue.

Wound healing involves seven key processes: inflammation, regeneration, cell migration, ECM synthesis, tissue remodeling, collagenization, and wound contraction.

Growth factors are small proteins that stimulate cell division and proliferation, playing a crucial role in the wound healing process.

Growth factors are released from various sources during the healing process, including platelets, serum, macrophages, and lymphocytes.

Regeneration is the replacement of lost tissue with identical cells, restoring the original structure.

Regeneration occurs through the proliferation of surviving cells and their migration to fill the gap left by the lost tissue.

A tissue's capacity for regeneration depends on its ability to proliferate, the damage to its supporting structures, and the severity of the injury.

Wound contraction is the reduction in the size of a wound by pulling the edges together.

Contraction accelerates healing by reducing the amount of tissue that needs to be replaced, but if excessive, can cause scarring.

Wound contraction is primarily driven by myofibroblasts, specialized cells that have contractile properties.

Cells that have characteristics of both fibroblasts and smooth muscle cells, playing a crucial role in wound contraction.

The process of healing a clean, uninfected surgical wound that is closed with sutures, resulting in minimal scarring.

The process of healing a wound with significant tissue loss, characterized by larger scar formation.

A meshwork of fibrin and blood cells that forms at a wound site, providing a temporary barrier and scaffolding for healing.

New tissue formed during wound healing, consisting of blood vessels, fibroblasts, and collagen, which gradually replaces the fibrin clot.

The process by which epithelial cells migrate across the wound surface to restore the skin barrier.

Dense, fibrous connective tissue that replaces the original tissue after a wound has healed, often lacking the function of the original tissue.

Myofibroblasts are key in wound contraction, bringing the edges of the wound together to minimize the gap and facilitate healing.

Epithelial cells migrate across the wound surface, forming a continuous barrier and protecting the underlying tissues from infection.

Healing by second intention involves a larger area of tissue loss, requiring greater deposition of collagen and the formation of more extensive scar tissue.

Macrophages are the key cells in tissue repair. They clear debris, fibrin, and foreign material, promoting angiogenesis and ECM deposition.

Scar formation involves a decrease in inflammation, increased collagen deposition, and regression of blood vessels, resulting in a pale, avascular scar.

Wound contraction helps to close large wounds by decreasing the gap between dermal edges and reducing the wound surface area.

Fractures heal with bone-forming tissue, unlike soft tissue wounds which heal with fibrous scar tissue.

Bone consists of calcified osteoid tissue made up of collagen fibers embedded in a mucoprotein matrix.

Immature bone with irregular collagen arrangement and less calcium content.

Mature bone with parallel collagen bundles, forming a stronger, organized structure.

Early movement can disrupt healing by causing persistent trauma to the wound, delaying the healing process.

Prior exposure to radiation can damage blood vessels, making it harder for the wound to get the nutrients it needs to heal.

A good blood supply is crucial for wound healing, as it delivers oxygen and nutrients to the injured area.

Systemic infections can delay wound healing because the body is fighting the infection, and less energy is available for repair.

Uncontrolled diabetes can slow down wound healing due to impaired circulation and nerve damage, making wounds more susceptible to infection.

A lack of protein in the diet can hinder wound healing because protein is the building block for new tissue.

While some anti-inflammatory medications can delay wound healing, most are safe at usual doses.

Wound dehiscence is when the edges of a wound separate or come apart, often due to poor suture material or technique.

Wound ulceration is when a wound fails to heal properly and forms an open sore, often due to inadequate granulation tissue formation.

An incisional hernia occurs when tissue bulges through a weakened abdominal wall resulting from inadequate scar formation.