Wound Healing and Tissue Repair - Dr. Natia Bolotashvili Introduction

Wound Healing Phases

• The proliferative phase is characterized by fibroblast activity and production of collagen.
• Vitamin C is required by fibroblasts to produce collagen during wound healing.

Inflammatory Phase

• Platelets play a crucial role in the inflammatory phase by releasing chemical signals that attract white blood cells to the wound site.
• Common symptoms associated with the inflammatory phase include pain, redness, swelling, and heat.
• Itching is NOT a common symptom associated with the inflammatory phase.

Proliferative Phase

• The initial wound tissue formed during the proliferative phase is known as granulation tissue.
• Capillary loops play a crucial role in wound healing during the proliferative phase by providing oxygen and nutrients to the wound site.

Remodelling Phase

• The main characteristic of the remodelling phase is the reorganization of collagen fibers to increase wound strength.
• Myofibroblasts are responsible for wound contraction during the remodelling phase.

Types of Wound Healing

• Atraumatic wound healing aims to reduce the inflammatory and proliferative responses.

Wound Healing Timeline

• Maximal tensile strength in a wound post-injury is typically achieved within 3-6 months.

Compartment Syndrome

• Compartment syndrome is indicated by a pressure level within muscles of greater than 30 mmHg.

Pressure Sores

• The defining characteristic of pressure sores is tissue damage caused by constant pressure and lack of movement.

Learn about the mechanism of wound healing and tissue repair as explained by Dr. Natia Bolotashvili. This quiz covers the normal wound healing phases including the inflammatory phase, proliferative phase, and remodelling phase.