18 Questions
How does high concentration of growth factor and strong Ras-MAPK signaling during wound healing impact the cells?
Enables cells to ignore the anti-growth effects of TGF-β Smad2/3 axis
What is the role of Smad2/3 in promoting EMT during wound healing?
Upregulate Snail family of transcription factors that promote EMT
How do tumors benefit from the TGF-β Smad2/3 axis in terms of EMT?
Promotes EMT and helps in EMT activation
What is the main function of Bone Morphogenetic Proteins (BMPs) in the context of TGF-β family?
Formation and maintenance of various organs including bone, cartilage, muscle, kidney, and blood vessels
What is the role of Oncogenes in tumor progression?
Promote cell proliferation and tumor growth
How do cells overcome the cytostatic effect of TGF-β during wound healing EMT?
High concentration of growth factor and strong Ras-MAPK signaling enable cells to ignore the anti-growth effects of TGF-β
What can TGFβ signaling trigger in cells, as mentioned in the text?
Cell migration
Which role can TGF-β play in cancer, according to the text?
Tumor suppressor
What is the main function of integrin-ECM interaction in cell migration as mentioned in the text?
Enhances cell motility
In addition to Smads, what other intracellular signaling pathways can TGFβ activate according to the text?
Ras-MAPK pathway
What is the main role of Grb2/SOS in TGF-β signaling pathway activation described in the text?
Recruitment for MAPK activation
Which phase of the cell-division cycle occurs before G1 (gap1) phase?
S phase
What is the role of Smad 2/3 in activating transcription?
Activating tumor suppressor genes
How do tumor cells overcome the cytostatic effect of TGF-β?
By activating oncogenes
What is the main reason that Tumor cells do not respond to the cytostatic effect of TGF-β?
Functional TGF-β receptor signaling
Which factor promotes epithelial-mesenchymal transition (EMT) and metastasis?
Snail family of transcription factor
How do tumor cells benefit from the TGF-β pathway?
By promoting oncogenes
Why does TGF-β have no cytostatic effect on tumor cells?
Loss of TSG function and overexpression of oncogenes
Test your knowledge on the process of wound healing in adult tissues, where epithelial cells may undergo EMT and cause fibrosis. Explore how the cytostatic effect of TGF-β is overcome during wound healing. This quiz covers key concepts in tissue repair and development.
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