Wound Healing EMT and TGF-β Cytostatic Effect Quiz
18 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

How does high concentration of growth factor and strong Ras-MAPK signaling during wound healing impact the cells?

  • Induces growth suppression through TGF-β receptor signaling
  • Enables cells to ignore the anti-growth effects of TGF-β Smad2/3 axis (correct)
  • Activates TSGs to inhibit cell proliferation
  • Promotes differentiation of epithelial cells

    • What is the role of Smad2/3 in promoting EMT during wound healing?

  • Suppress the formation of fibrous connective tissue
  • Inhibit cell migration
  • Activate oncogenes to promote cell differentiation
  • Upregulate Snail family of transcription factors that promote EMT (correct)

    • How do tumors benefit from the TGF-β Smad2/3 axis in terms of EMT?

  • Inhibits EMT process in tumor cells
  • Prevents metastasis
  • Promotes EMT and helps in EMT activation (correct)
  • Induces apoptosis in cancer cells

    • What is the main function of Bone Morphogenetic Proteins (BMPs) in the context of TGF-β family?

    <p>Formation and maintenance of various organs including bone, cartilage, muscle, kidney, and blood vessels</p> Signup and view all the answers

    What is the role of Oncogenes in tumor progression?

    <p>Promote cell proliferation and tumor growth</p> Signup and view all the answers

    How do cells overcome the cytostatic effect of TGF-β during wound healing EMT?

    <p>High concentration of growth factor and strong Ras-MAPK signaling enable cells to ignore the anti-growth effects of TGF-β</p> Signup and view all the answers

    What can TGFβ signaling trigger in cells, as mentioned in the text?

    <p>Cell migration</p> Signup and view all the answers

    Which role can TGF-β play in cancer, according to the text?

    <p>Tumor suppressor</p> Signup and view all the answers

    What is the main function of integrin-ECM interaction in cell migration as mentioned in the text?

    <p>Enhances cell motility</p> Signup and view all the answers

    In addition to Smads, what other intracellular signaling pathways can TGFβ activate according to the text?

    <p>Ras-MAPK pathway</p> Signup and view all the answers

    What is the main role of Grb2/SOS in TGF-β signaling pathway activation described in the text?

    <p>Recruitment for MAPK activation</p> Signup and view all the answers

    Which phase of the cell-division cycle occurs before G1 (gap1) phase?

    <p>S phase</p> Signup and view all the answers

    What is the role of Smad 2/3 in activating transcription?

    <p>Activating tumor suppressor genes</p> Signup and view all the answers

    How do tumor cells overcome the cytostatic effect of TGF-β?

    <p>By activating oncogenes</p> Signup and view all the answers

    What is the main reason that Tumor cells do not respond to the cytostatic effect of TGF-β?

    <p>Functional TGF-β receptor signaling</p> Signup and view all the answers

    Which factor promotes epithelial-mesenchymal transition (EMT) and metastasis?

    <p>Snail family of transcription factor</p> Signup and view all the answers

    How do tumor cells benefit from the TGF-β pathway?

    <p>By promoting oncogenes</p> Signup and view all the answers

    Why does TGF-β have no cytostatic effect on tumor cells?

    <p>Loss of TSG function and overexpression of oncogenes</p> Signup and view all the answers

    More Like This

    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser