50 Questions
Which phase of wound healing involves the formation of granulation tissue and collagen formation?
Proliferation
What happens immediately after an injury in the haemostasis phase of wound healing?
Platelet aggregation
What is the first thing that happens in the clotting cascade during haemostasis?
Platelet aggregation
Which cells are involved in platelet aggregation during haemostasis?
Platelets
What is the final phase of wound healing that involves the remodeling of collagen?
Maturation
Which type of collagen is replaced by type I mature collagen during the maturation phase of wound healing?
Type III immature collagen
What is one of the patient factors that can affect wound healing?
Age
Which factor can delay all stages of healing?
Corticosteroids
What can radiation treatment lead to during wound healing?
Tissue fibrosis and vascular scarring
Which component of the extracellular matrix undergoes changes during the maturation phase of wound healing?
Type I mature collagen
During the inflammatory stage, why do we get vasodilation?
To bring in cytokines and inflammatory mediators
What cells are attracted to the cytokines in the platelet clot during the inflammatory stage?
Neutrophils and macrophages
What gives granulation tissue its shiny and red appearance?
New blood vessels
What is the role of myofibroblasts in the proliferation phase?
To promote wound contraction
Why is it important to measure or take pictures of the wound during the proliferation 2 phase?
To evaluate the deficit reduction
Which phase of wound healing involves the formation of granulation tissue and collagen formation?
Proliferation
What is the role of myofibroblasts in the proliferation phase?
Form granulation tissue
What is the first thing that happens in the clotting cascade during haemostasis?
Platelet aggregation
Which type of collagen is replaced by type I mature collagen during the maturation phase of wound healing?
Type III immature collagen
What can affect wound healing in patients?
Age
Which factor can delay all stages of healing?
Corticosteroids
What is the role of myofibroblasts in the proliferation phase of wound healing?
Formation of granulation tissue
Which phase of wound healing is characterized by the formation of granulation tissue and the proliferation of fibroblasts and blood vessels?
Proliferation (repair phase)
What type of cells are responsible for destroying bacteria and devitalized necrotic tissue during the inflammatory stage of wound healing?
Macrophages
What is the purpose of the platelet plug in wound healing?
To prevent blood loss
During which phase of wound healing does the formation of granulation tissue and collagen occur?
Proliferation
What is the first phase of wound healing that occurs immediately after an injury?
Haemostasis
What is the role of platelet aggregation during haemostasis?
To activate the clotting cascade
What happens during the maturation phase of wound healing?
Remodeling of collagen
Which phase of wound healing involves the release of cytokines from platelets?
Haemostasis
Which type of collagen is replaced by type I mature collagen during the maturation phase of wound healing?
Type III immature collagen
What is one of the patient factors that can affect wound healing?
Age
What factor can delay all stages of healing?
Concurrent treatment
What is the role of myofibroblasts in the proliferation phase of wound healing?
Formation of granulation tissue
What can radiation treatment lead to during wound healing?
Tissue fibrosis and vascular scarring
During the inflammatory stage of wound healing, which cells are responsible for destroying bacteria and devitalized necrotic tissue?
Macrophages
What is the main purpose of the platelet plug in wound healing?
To prevent blood loss
Which phase of wound healing involves the formation of granulation tissue and the proliferation of fibroblasts and blood vessels?
Proliferation (repair) phase
What gives granulation tissue its shiny and red appearance?
Blood vessels
What type of cells contract and cause wound contraction during the proliferation 2 phase of wound healing?
Myofibroblasts
• The first phase of wound healing is ______ and inflammation – continues for a couple of days.
haemostasis
• During haemostasis, the clotting cascade consists of ______ and extrinsic factors.
intrinsic
• Platelet aggregation during haemostasis is stabilized by ______ formation.
fibrin
• During the inflammatory stage, cytokines in the platelet clot attract the white blood cells. Initially it is neutrophils but then ______.
macrophages
• The fibroblasts proliferate and they are responsible for making the new extracellular matrix, elastin, and collagen ______.
fibers
• The wound contraction and new epithelial tissue we should start to see the deficit ______ in this phase.
shrinking
You may not be able to do anything about ______ but you may be able to reduce the dose
corticosteroids
This leads to tissue fibrosis and vascular scarring
radiation treatment
Wound factors can be the location of the ______, the tension on the ______, the movements of the ______, the local blood supply of the ______.
wound
Age, comorbidities, and nutrition status are examples of ______ factors that can affect wound healing.
patient
Study Notes
Wound Healing Phases
- The proliferation phase involves the formation of granulation tissue and collagen formation.
- The final phase of wound healing is the remodeling phase, which involves the remodeling of collagen.
Haemostasis Phase
- Immediately after an injury, the haemostasis phase involves platelet aggregation and clotting cascade.
- The first thing that happens in the clotting cascade is the release of tissue factor.
- Platelets aggregate during haemostasis, facilitated by thromboxane A2.
Inflammatory Stage
- Vasodilation occurs during the inflammatory stage due to the release of histamine from platelets.
- Cytokines in the platelet clot attract white blood cells, initially neutrophils and then macrophages.
Proliferation Phase
- Myofibroblasts play a crucial role in the proliferation phase, causing wound contraction.
- Granulation tissue gets its shiny and red appearance due to the proliferation of new blood vessels.
- It's essential to measure or take pictures of the wound during the proliferation 2 phase to track progress.
Maturation Phase
- Type III collagen is replaced by type I mature collagen during the maturation phase.
- The extracellular matrix undergoes changes during the maturation phase.
- Radiation treatment can lead to tissue fibrosis and vascular scarring during wound healing.
Factors Affecting Wound Healing
- Patient factors that can affect wound healing include age, comorbidities, and nutrition status.
- Radiation treatment can delay all stages of healing.
- Wound factors such as location, tension, movement, and local blood supply can also affect wound healing.
Test your knowledge on the phases of wound healing and understand the importance of proper management in the healing process. Explore the stages of haemostasis, inflammation, and platelet aggregation.
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