Podcast
Questions and Answers
Which phase of wound healing involves the formation of granulation tissue and collagen formation?
Which phase of wound healing involves the formation of granulation tissue and collagen formation?
- Proliferation (correct)
- Maturation
- Haemostasis
- Inflammation
What happens immediately after an injury in the haemostasis phase of wound healing?
What happens immediately after an injury in the haemostasis phase of wound healing?
- Platelet aggregation (correct)
- Release of cytokines
- Fibrin formation
- Remodeling of collagen
What is the first thing that happens in the clotting cascade during haemostasis?
What is the first thing that happens in the clotting cascade during haemostasis?
- Platelet aggregation (correct)
- Release of cytokines
- Fibrin formation
- Remodeling of collagen
Which cells are involved in platelet aggregation during haemostasis?
Which cells are involved in platelet aggregation during haemostasis?
What is the final phase of wound healing that involves the remodeling of collagen?
What is the final phase of wound healing that involves the remodeling of collagen?
Which type of collagen is replaced by type I mature collagen during the maturation phase of wound healing?
Which type of collagen is replaced by type I mature collagen during the maturation phase of wound healing?
What is one of the patient factors that can affect wound healing?
What is one of the patient factors that can affect wound healing?
Which factor can delay all stages of healing?
Which factor can delay all stages of healing?
What can radiation treatment lead to during wound healing?
What can radiation treatment lead to during wound healing?
Which component of the extracellular matrix undergoes changes during the maturation phase of wound healing?
Which component of the extracellular matrix undergoes changes during the maturation phase of wound healing?
During the inflammatory stage, why do we get vasodilation?
During the inflammatory stage, why do we get vasodilation?
What cells are attracted to the cytokines in the platelet clot during the inflammatory stage?
What cells are attracted to the cytokines in the platelet clot during the inflammatory stage?
What gives granulation tissue its shiny and red appearance?
What gives granulation tissue its shiny and red appearance?
What is the role of myofibroblasts in the proliferation phase?
What is the role of myofibroblasts in the proliferation phase?
Why is it important to measure or take pictures of the wound during the proliferation 2 phase?
Why is it important to measure or take pictures of the wound during the proliferation 2 phase?
Which phase of wound healing involves the formation of granulation tissue and collagen formation?
Which phase of wound healing involves the formation of granulation tissue and collagen formation?
What is the role of myofibroblasts in the proliferation phase?
What is the role of myofibroblasts in the proliferation phase?
What is the first thing that happens in the clotting cascade during haemostasis?
What is the first thing that happens in the clotting cascade during haemostasis?
Which type of collagen is replaced by type I mature collagen during the maturation phase of wound healing?
Which type of collagen is replaced by type I mature collagen during the maturation phase of wound healing?
What can affect wound healing in patients?
What can affect wound healing in patients?
Which factor can delay all stages of healing?
Which factor can delay all stages of healing?
What is the role of myofibroblasts in the proliferation phase of wound healing?
What is the role of myofibroblasts in the proliferation phase of wound healing?
Which phase of wound healing is characterized by the formation of granulation tissue and the proliferation of fibroblasts and blood vessels?
Which phase of wound healing is characterized by the formation of granulation tissue and the proliferation of fibroblasts and blood vessels?
What type of cells are responsible for destroying bacteria and devitalized necrotic tissue during the inflammatory stage of wound healing?
What type of cells are responsible for destroying bacteria and devitalized necrotic tissue during the inflammatory stage of wound healing?
What is the purpose of the platelet plug in wound healing?
What is the purpose of the platelet plug in wound healing?
During which phase of wound healing does the formation of granulation tissue and collagen occur?
During which phase of wound healing does the formation of granulation tissue and collagen occur?
What is the first phase of wound healing that occurs immediately after an injury?
What is the first phase of wound healing that occurs immediately after an injury?
What is the role of platelet aggregation during haemostasis?
What is the role of platelet aggregation during haemostasis?
What happens during the maturation phase of wound healing?
What happens during the maturation phase of wound healing?
Which phase of wound healing involves the release of cytokines from platelets?
Which phase of wound healing involves the release of cytokines from platelets?
Which type of collagen is replaced by type I mature collagen during the maturation phase of wound healing?
Which type of collagen is replaced by type I mature collagen during the maturation phase of wound healing?
What is one of the patient factors that can affect wound healing?
What is one of the patient factors that can affect wound healing?
What factor can delay all stages of healing?
What factor can delay all stages of healing?
What is the role of myofibroblasts in the proliferation phase of wound healing?
What is the role of myofibroblasts in the proliferation phase of wound healing?
What can radiation treatment lead to during wound healing?
What can radiation treatment lead to during wound healing?
During the inflammatory stage of wound healing, which cells are responsible for destroying bacteria and devitalized necrotic tissue?
During the inflammatory stage of wound healing, which cells are responsible for destroying bacteria and devitalized necrotic tissue?
What is the main purpose of the platelet plug in wound healing?
What is the main purpose of the platelet plug in wound healing?
Which phase of wound healing involves the formation of granulation tissue and the proliferation of fibroblasts and blood vessels?
Which phase of wound healing involves the formation of granulation tissue and the proliferation of fibroblasts and blood vessels?
What gives granulation tissue its shiny and red appearance?
What gives granulation tissue its shiny and red appearance?
What type of cells contract and cause wound contraction during the proliferation 2 phase of wound healing?
What type of cells contract and cause wound contraction during the proliferation 2 phase of wound healing?
• The first phase of wound healing is ______ and inflammation – continues for a couple of days.
• The first phase of wound healing is ______ and inflammation – continues for a couple of days.
• During haemostasis, the clotting cascade consists of ______ and extrinsic factors.
• During haemostasis, the clotting cascade consists of ______ and extrinsic factors.
• Platelet aggregation during haemostasis is stabilized by ______ formation.
• Platelet aggregation during haemostasis is stabilized by ______ formation.
• During the inflammatory stage, cytokines in the platelet clot attract the white blood cells. Initially it is neutrophils but then ______.
• During the inflammatory stage, cytokines in the platelet clot attract the white blood cells. Initially it is neutrophils but then ______.
• The fibroblasts proliferate and they are responsible for making the new extracellular matrix, elastin, and collagen ______.
• The fibroblasts proliferate and they are responsible for making the new extracellular matrix, elastin, and collagen ______.
• The wound contraction and new epithelial tissue we should start to see the deficit ______ in this phase.
• The wound contraction and new epithelial tissue we should start to see the deficit ______ in this phase.
You may not be able to do anything about ______ but you may be able to reduce the dose
You may not be able to do anything about ______ but you may be able to reduce the dose
This leads to tissue fibrosis and vascular scarring
This leads to tissue fibrosis and vascular scarring
Wound factors can be the location of the ______, the tension on the ______, the movements of the ______, the local blood supply of the ______.
Wound factors can be the location of the ______, the tension on the ______, the movements of the ______, the local blood supply of the ______.
Age, comorbidities, and nutrition status are examples of ______ factors that can affect wound healing.
Age, comorbidities, and nutrition status are examples of ______ factors that can affect wound healing.
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Study Notes
Wound Healing Phases
- The proliferation phase involves the formation of granulation tissue and collagen formation.
- The final phase of wound healing is the remodeling phase, which involves the remodeling of collagen.
Haemostasis Phase
- Immediately after an injury, the haemostasis phase involves platelet aggregation and clotting cascade.
- The first thing that happens in the clotting cascade is the release of tissue factor.
- Platelets aggregate during haemostasis, facilitated by thromboxane A2.
Inflammatory Stage
- Vasodilation occurs during the inflammatory stage due to the release of histamine from platelets.
- Cytokines in the platelet clot attract white blood cells, initially neutrophils and then macrophages.
Proliferation Phase
- Myofibroblasts play a crucial role in the proliferation phase, causing wound contraction.
- Granulation tissue gets its shiny and red appearance due to the proliferation of new blood vessels.
- It's essential to measure or take pictures of the wound during the proliferation 2 phase to track progress.
Maturation Phase
- Type III collagen is replaced by type I mature collagen during the maturation phase.
- The extracellular matrix undergoes changes during the maturation phase.
- Radiation treatment can lead to tissue fibrosis and vascular scarring during wound healing.
Factors Affecting Wound Healing
- Patient factors that can affect wound healing include age, comorbidities, and nutrition status.
- Radiation treatment can delay all stages of healing.
- Wound factors such as location, tension, movement, and local blood supply can also affect wound healing.
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