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Questions and Answers
What are the cardinal features of inflammation?
What is the outcome of tissue damage characterized by regeneration and/or scarring?
What is the term often used as a synonym for 'healing'?
What is the reaction in tissue that consists mainly of responses of blood vessels and leukocytes?
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What are the conditions required for healing by scar formation (fibrosis) and healing by regeneration?
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What are the cardinal features of inflammation in Latin?
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What is the outcome of tissue damage that may be the result of a non-inflammatory process?
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What are the types of cells based on proliferative capacity?
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Which type of cells continually divide throughout life?
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Under what conditions do stable cells re-enter the cell cycle?
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Which factor impairs tissue repair processes?
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Which type of cells cannot undergo mitosis postnatally?
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What is the main component of the extracellular matrix (ECM)?
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In which type of tissue does scarring occur due to lack of surviving tissue cells?
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Which growth factor plays a key role in repair and regeneration?
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What are the phases of the cell cycle?
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What is the process called when mild injuries are repaired by the formation of new tissue?
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Which cells are categorized as stable based on their proliferative capacity?
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What is the deposition of fibrous tissue into a mature scar a part of?
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What is the role of fibroblasts in tissue repair mechanisms?
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What is the main characteristic of granulation tissue?
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What do myofibroblasts contribute to in wound healing?
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What is the main difference between cutaneous wound healing by first intention and second intention?
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What is the characteristic of embryonic stem cells?
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Where are stem cell niches found?
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What is the main component of granulation tissue?
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What type of collagen do fibroblasts in granulation tissue synthesize?
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What happens to granulation tissue weeks to months after injury?
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What is the role of injury-induced inflammation in scar formation?
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What is the capacity of progenitor cells?
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What is the differentiation capacity of adult stem cells?
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What is the potential use of embryonic stem cells?
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Study Notes
Understanding Granulation Tissue and Scar Formation
- Granulation tissue is formed after tissue injury, characterized by angiogenesis and fibroblast proliferation, and has a pink, soft, granular appearance.
- The granulation tissue contains newly formed small blood vessels originating from preexisting blood vessels and immature vessels with leaky interendothelial junctions, causing edema.
- Fibroblasts in granulation tissue synthesize Type III collagen, and myofibroblasts are important in wound contraction.
- Weeks to months after injury, granulation tissue transforms into a mature scar, with an increase in collagen and other extracellular matrix proteins, and a decrease in fibroblasts and vascularity.
- Scar formation involves injury-induced inflammation, vascularized granulation tissue, and deposition of extracellular matrix to form the scar.
- Cutaneous wound healing by first intention involves regeneration with wound edges close together, while healing by second intention involves more scarring and less regeneration with farther apart wound edges.
- Progenitor cells have unlimited proliferative capacity and undergo asymmetric replication, retaining self-renewing capacity while the other cell enters a differentiation pathway.
- Embryonic stem cells are pluripotent and can be isolated from blastocysts, potentially used for therapeutic cloning and producing knockout mice.
- Adult stem cells have a more restricted differentiation capacity and are generally lineage-specific, but stem cells with broad differentiation potential have been found in various adult tissues.
- Stem cell niches are specific locations in tissues where stem cells are found, including crypts in the intestine, hair follicle bulge, and canals of Hering in the liver.
- The text includes references to authoritative sources such as Kumar et al.'s "Robbins Basic Pathology" and Kumar et al.'s "Robbins and Cotran Pathologic Basis of Disease."
- The text also acknowledges special thanks to Paul Murphy, M.D., from the Department of Pathology at the University of Kentucky, and lists additional resources such as WebPath, Pathoma, and Access Medicine.
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Description
Test your knowledge of granulation tissue, scar formation, and stem cells with this quiz. Explore the processes involved in wound healing, scar maturation, and the characteristics of different types of stem cells. Whether you're a student or professional in the medical field, this quiz covers essential concepts backed by authoritative sources and references.