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Questions and Answers

What is the primary mechanism of action for Nitrates?

Nitrates cause vasodilation, thereby increasing oxygenated blood flow to the heart.

What are the main therapeutic uses of Nitrates?

Nitrates are used for treating acute angina attacks and for prophylaxis (prevention) of angina.

List the common adverse effects associated with Nitrate administration.

Hypotension (which can be significant), headache, and flushing.

Match the following Nitrate drugs with their brand names:

<p>Nitroglycerin = Nitrostat Isosorbide Mononitrate = Imdur Isosorbide Dinitrate = Isordil</p> Signup and view all the answers

How should sublingual nitroglycerin be administered during an acute angina attack according to standard teaching?

<p>Give one tablet sublingually every 5 minutes for up to 3 doses. If pain is still present after 3 doses, seek immediate medical attention (e.g., call 911 or the doctor).</p> Signup and view all the answers

True or False: Nitroglycerin tablets lose potency over time and should be kept in their original brown bottle.

<p>True (A)</p> Signup and view all the answers

What sensation under the tongue might indicate that sublingual nitroglycerin is still potent?

<p>A slight tingling or stinging sensation.</p> Signup and view all the answers

What instructions should be given regarding nitroglycerin patches?

<p>Rotate patch application sites daily, remove the old patch before applying a new one, and ensure there is a patch-free period (usually at night) to prevent tolerance.</p> Signup and view all the answers

Why should patients taking nitrates be advised to rise slowly from a lying or sitting position?

<p>To prevent orthostatic hypotension (a sudden drop in blood pressure upon standing), which can cause dizziness or fainting.</p> Signup and view all the answers

Describe the mechanism of action of Beta Blockers.

<p>Beta Blockers slow the heart rate and cause vasodilation, which reduces the heart's workload and myocardial oxygen demand.</p> Signup and view all the answers

What are the primary clinical uses for Beta Blockers?

<p>They are used as a maintenance drug for angina, hypertension, and Congestive Heart Failure (CHF).</p> Signup and view all the answers

What are potential adverse effects of Beta Blockers?

<p>Bradycardia (slow heart rate), hypotension (low blood pressure), and bronchospasm (especially with nonselective beta blockers).</p> Signup and view all the answers

What is the brand name for the beta blocker Metoprolol?

<p>Lopressor</p> Signup and view all the answers

How do Bile Acid Resins work to lower cholesterol?

<p>They bind with bile acids in the intestine, preventing their reabsorption. This forces the liver to use more cholesterol from the bloodstream to synthesize new bile acids.</p> Signup and view all the answers

What is the main indication for using Bile Acid Resins?

<p>Hyperlipidemia (high cholesterol levels).</p> Signup and view all the answers

List the common adverse effects of Bile Acid Resins.

<p>Constipation, general GI distress (bloating, gas), and potential malabsorption of fat-soluble vitamins like vitamin K.</p> Signup and view all the answers

What is the brand name for the bile acid resin Cholestyramine?

<p>Questran</p> Signup and view all the answers

What is the mechanism of action for HMG-CoA Reductase Inhibitors (Statins)?

<p>They inhibit HMG-CoA reductase, a key enzyme in the liver responsible for cholesterol synthesis, and may also promote the breakdown of existing cholesterol.</p> Signup and view all the answers

What is the primary use for HMG-CoA Reductase Inhibitors (Statins)?

<p>Hyperlipidemia (high cholesterol levels).</p> Signup and view all the answers

Identify potential adverse effects associated with HMG-CoA Reductase Inhibitors (Statins).

<p>Constipation, flatulence, and potential muscle toxicity (myopathy, rhabdomyolysis).</p> Signup and view all the answers

What is the brand name for the HMG-CoA reductase inhibitor Simvastatin?

<p>Zocor</p> Signup and view all the answers

How do Fibric Acid Derivatives work to modify lipid levels?

<p>They stimulate the liver to break down VLDL (Very Low-Density Lipoprotein) and LDL (Low-Density Lipoprotein) and increase the excretion of cholesterol in the feces.</p> Signup and view all the answers

What are common adverse effects of Fibric Acid Derivatives?

<p>Nausea, vomiting, diarrhea (N/V/D), and an increased risk of cholelithiasis (gallstones).</p> Signup and view all the answers

Match the following Fibric Acid Derivative brand names with their generic names:

<p>Tricor = Fenofibrate Lopid = Gemfibrozil</p> Signup and view all the answers

What are the two main effects of Cardiotonics (like Digoxin) on the heart?

<p>They increase the force of contraction of the myocardium (positive inotropic effect) and slow the heart rate (negative chronotropic effect).</p> Signup and view all the answers

List potential adverse reactions associated with Cardiotonics.

<p>Headache, weakness, drowsiness, visual disturbances (blurred vision, yellow/green halos), arrhythmias, GI upset (nausea, vomiting, diarrhea), and anorexia.</p> Signup and view all the answers

What are the characteristic signs and symptoms of Digoxin (Dig) toxicity?

<p>Visual disturbances (especially green/yellow halos), anorexia (loss of appetite - a significant sign), nausea, vomiting, diarrhea, and potentially life-threatening arrhythmias. Hypokalemia (low potassium) increases the risk.</p> Signup and view all the answers

What is the antidote used for severe Digoxin toxicity?

<p>Digibind (digoxin immune Fab).</p> Signup and view all the answers

What is the therapeutic serum level range for Digoxin?

<p>0.8 - 2.0 ng/mL.</p> Signup and view all the answers

What electrolyte imbalance significantly increases a patient's risk for developing Digoxin toxicity?

<p>Hypokalemia (low potassium levels).</p> Signup and view all the answers

What vital sign must be carefully assessed before administering a dose of Digoxin?

<p>Apical pulse rate (taken for a full minute).</p> Signup and view all the answers

Describe the mechanism of action for Angiotensin-Converting Enzyme Inhibitors (ACEIs).

<p>ACEIs block the conversion of angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor, so blocking its formation leads to vasodilation and reduced blood pressure.</p> Signup and view all the answers

What are the primary therapeutic uses for ACE Inhibitors?

<p>Hypertension and heart failure.</p> Signup and view all the answers

What is a characteristic and often troublesome adverse effect of ACE Inhibitors?

<p>A persistent dry cough.</p> Signup and view all the answers

Match the following ACE Inhibitor drugs with their brand names:

<p>Benazepril = Lotensin Lisinopril = Zestril Captopril = Capoten</p> Signup and view all the answers

How do Calcium Channel Blockers (CCBs) exert their effects?

<p>They block the movement of calcium ions across cell membranes, particularly in vascular smooth muscle and cardiac cells. This results in vasodilation, slowed heart rate, and decreased myocardial contractility.</p> Signup and view all the answers

What conditions are Calcium Channel Blockers used to treat?

<p>Hypertension, angina, and certain types of cardiac arrhythmias.</p> Signup and view all the answers

Identify common adverse effects associated with Calcium Channel Blockers.

<p>Peripheral edema (ankle swelling), headache, constipation, nasal congestion, hypotension, and bradycardia (especially with heart-rate slowing CCBs like diltiazem).</p> Signup and view all the answers

Match the following Calcium Channel Blocker drugs with their brand names:

<p>Amlodipine = Norvasc Diltiazem = Cardizem</p> Signup and view all the answers

What is the mechanism of action for Loop Diuretics?

<p>They inhibit the reabsorption of sodium and chloride primarily in the ascending loop of Henle in the kidneys.</p> Signup and view all the answers

What are the main clinical uses for Loop Diuretics?

<p>Treatment of hypertension (though not always first-line), edema associated with heart failure (CHF), renal failure, or cirrhosis.</p> Signup and view all the answers

What is a common cardiovascular adverse effect of Loop Diuretics?

<p>Orthostatic hypotension.</p> Signup and view all the answers

Match the following Loop Diuretic drugs with their brand names:

<p>Furosemide = Lasix Bumetanide = Bumex</p> Signup and view all the answers

How do Centrally-Acting Antiadrenergics lower blood pressure?

<p>According to the provided text, they block alpha adrenergic receptors producing vasodilation. (Note: The primary mechanism is actually stimulation of alpha-2 receptors in the CNS, reducing sympathetic outflow).</p> Signup and view all the answers

What is the primary indication for Centrally-Acting Antiadrenergics?

<p>Hypertension.</p> Signup and view all the answers

List common adverse effects of Centrally-Acting Antiadrenergics.

<p>Drowsiness, sedation, dry mouth, constipation, and syncope (fainting).</p> Signup and view all the answers

Match the following Centrally-Acting Antiadrenergic drugs with their brand names:

<p>Clonidine = Catapres Methyldopa = Aldomet</p> Signup and view all the answers

What is the mechanism of action for oral anticoagulants like Warfarin?

<p>Warfarin interferes with the synthesis of Vitamin K-dependent clotting factors (Factors II, VII, IX, and X) in the liver.</p> Signup and view all the answers

What are the primary indications for using oral anticoagulants (e.g., Warfarin)?

<p>Prevention and treatment of Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE), and prevention/treatment of thromboembolism associated with Atrial Fibrillation (A-fib) or prosthetic heart valves.</p> Signup and view all the answers

What is the main and most serious adverse effect of oral anticoagulants?

<p>Bleeding.</p> Signup and view all the answers

What is the brand name for the oral anticoagulant Warfarin?

<p>Coumadin</p> Signup and view all the answers

Which laboratory tests are used to monitor Warfarin (Coumadin) therapy?

<p>Prothrombin Time (PT) and International Normalized Ratio (INR).</p> Signup and view all the answers

What are the typical target therapeutic ranges for PT and INR for a patient on Warfarin?

<p>PT: 1.2 to 1.5 times the control value; INR: 2.0 to 3.0 (though target range may be higher for specific indications like mechanical heart valves).</p> Signup and view all the answers

What is the pharmacological antidote for Warfarin overdose or excessive anticoagulation?

<p>Vitamin K (phytonadione).</p> Signup and view all the answers

What is the mechanism of action for parenteral anticoagulants like Heparin?

<p>Heparin inhibits the formation of fibrin clots, primarily by potentiating the activity of antithrombin III, which inactivates thrombin and Factor Xa.</p> Signup and view all the answers

What are the clinical uses for parenteral anticoagulants such as Heparin?

<p>Prevention and treatment of DVT and PE, prevention and treatment of emboli associated with A-fib, treatment of acute myocardial infarction, and maintaining patency of IV catheters (low-dose heparin flushes).</p> Signup and view all the answers

What is the primary adverse effect risk associated with parenteral anticoagulants?

<p>Bleeding.</p> Signup and view all the answers

Which laboratory test is typically used to monitor intravenous Heparin therapy?

<p>Partial Thromboplastin Time (PTT) or activated Partial Thromboplastin Time (aPTT).</p> Signup and view all the answers

What is the target therapeutic range for PTT/aPTT for a patient receiving a therapeutic Heparin infusion?

<p>Typically 1.5 to 2.5 times the baseline control value.</p> Signup and view all the answers

What is the antidote for Heparin overdose?

<p>Protamine sulfate.</p> Signup and view all the answers

What is a potential advantage of Low Molecular Weight Heparin (LMWH) compared to unfractionated Heparin?

<p>Bleeding is generally less likely with LMWH.</p> Signup and view all the answers

What is the brand name for the Low Molecular Weight Heparin (LMWH) Enoxaparin?

<p>Lovenox</p> Signup and view all the answers

How is Low Molecular Weight Heparin (LMWH), such as Lovenox, typically administered?

<p>By subcutaneous injection only, commonly in the anterolateral or posterolateral abdominal wall ('love handles').</p> Signup and view all the answers

True or False: When administering a prefilled syringe of LMWH (e.g., Lovenox), the air bubble should be expelled before injection.

<p>False (B)</p> Signup and view all the answers

True or False: After injecting LMWH subcutaneously, the site should be aspirated before injection and massaged afterward.

<p>False (B)</p> Signup and view all the answers

What is the general action of Disease-Modifying Antirheumatic Drugs (DMARDs)?

<p>They produce immunosuppression, which helps to slow down the progression of autoimmune diseases like rheumatoid arthritis.</p> Signup and view all the answers

What is the primary condition treated with DMARDs?

<p>Rheumatoid arthritis (RA).</p> Signup and view all the answers

List potential adverse effects associated with DMARDs.

<p>Increased susceptibility to infections (due to immunosuppression), nausea, stomatitis (mouth sores), and alopecia (hair loss).</p> Signup and view all the answers

What laboratory test is often used to monitor inflammatory activity in conditions like rheumatoid arthritis, where DMARDs are used?

<p>Erythrocyte Sedimentation Rate (ESR).</p> Signup and view all the answers

Match the following DMARDs with their brand names:

<p>Adalimumab = Humira Etanercept = Enbrel Methotrexate = Rheumatrex</p> Signup and view all the answers

What specific blood count abnormalities are a concern with Methotrexate, and what monitoring is required?

<p>Thrombocytopenia (low platelets) and leukopenia (low white blood cells) are concerns. Hematology (blood counts), liver function, and renal function tests should be monitored regularly (e.g., every 3 months).</p> Signup and view all the answers

What is the mechanism of action for Bisphosphonates?

<p>They act directly on bone tissue to inhibit osteoclast activity, thereby slowing down both normal and abnormal bone resorption (breakdown).</p> Signup and view all the answers

What are the primary clinical uses for Bisphosphonates?

<p>Treatment and prevention of osteoporosis, and management of hypercalcemia (high calcium levels), often associated with malignancy.</p> Signup and view all the answers

Describe common gastrointestinal adverse effects associated with oral Bisphosphonates.

<p>Acid regurgitation (heartburn), dysphagia (difficulty swallowing), nausea, and diarrhea.</p> Signup and view all the answers

Name two common Bisphosphonate drugs used for osteoporosis.

<p>Alendronate (Fosamax) and Ibandronate (Boniva).</p> Signup and view all the answers

What is the generally accepted mechanism of action for Nonsteroidal Anti-inflammatory Drugs (NSAIDs)?

<p>They are thought to inhibit the synthesis of prostaglandins, which are mediators of inflammation, pain, and fever.</p> Signup and view all the answers

What are the common uses for NSAIDs?

<p>Management of chronic pain (especially inflammatory pain like arthritis), acute pain, and fever reduction.</p> Signup and view all the answers

List common adverse effects associated with NSAID use.

<p>Gastrointestinal issues like nausea, vomiting, epigastric pain, bloating, and potentially GI bleeding/ulceration. They can also reduce the effectiveness of some hypertension medications.</p> Signup and view all the answers

Match the following NSAID drugs with their common brand names:

<p>Ibuprofen = Motrin (or Advil) Naproxen = Aleve Celecoxib = Celebrex</p> Signup and view all the answers

What allergy is a specific contraindication for taking Celecoxib (Celebrex)?

<p>Sulfa allergy.</p> Signup and view all the answers

What are the primary pharmacological actions of Salicylates, such as Aspirin?

<p>They inhibit prostaglandin synthesis, leading to anti-inflammatory, analgesic (pain relief), and antipyretic (fever reduction) effects.</p> Signup and view all the answers

What are the clinical uses for Salicylates like Aspirin?

<p>Treatment of mild to moderate pain, reducing inflammation, and, in low doses, prevention of cardiovascular events (like heart attack and stroke) due to its antiplatelet effect.</p> Signup and view all the answers

Identify two significant adverse effects associated with Salicylate (Aspirin) use.

<p>Gastrointestinal (GI) ulcerations and bleeding, and tinnitus (ringing in the ears), which can be a sign of ototoxicity or overdose.</p> Signup and view all the answers

What is a common brand name for enteric-coated Aspirin?

<p>Ecotrin</p> Signup and view all the answers

When initiating an intravenous (IV) line, should the nurse start insertion attempts proximally or distally on the limb?

<p>Start distally (e.g., hand) and work proximally (up the arm).</p> Signup and view all the answers

What is the recommended minimum frequency for monitoring an IV insertion site?

<p>Monitor the site at least every 2 hours.</p> Signup and view all the answers

According to typical institutional protocols, how often should a peripheral IV catheter site be changed?

<p>Usually every 72 hours (3 days).</p> Signup and view all the answers

How often should continuously infusing IV fluid bags typically be changed?

<p>Every 24 hours.</p> Signup and view all the answers

How often should primary and secondary continuous IV tubing typically be changed?

<p>Generally every 72 to 96 hours, and also whenever an IV site is changed.</p> Signup and view all the answers

List potential local and systemic complications associated with IV therapy.

<p>Infiltration (fluid leaking into tissue), Phlebitis (vein inflammation), localized Infection, Hematoma (bruising), Fluid overload (systemic), Venous vasospasm, and Emboli (air or clot - systemic).</p> Signup and view all the answers

Describe the key signs and symptoms of a venous air embolism.

<p>Cardiovascular: Hypotension, weak/thready pulse, chest pain, jugular vein distention (JVD). Respiratory: Dyspnea (shortness of breath), cyanosis (bluish skin), tachypnea (rapid breathing), expiratory wheezes, cough, pulmonary edema, decreased breath sounds, hemoptysis (coughing up blood). Neurological: Changes in mental status (confusion, coma), anxiousness, seizures, lightheadedness, weakness.</p> Signup and view all the answers

How do Nitrates work to treat cardiac conditions?

<p>Nitrates cause vasodilation, thereby increasing oxygenated blood flow to the heart.</p> Signup and view all the answers

What are the primary uses for Nitrates?

<p>Acute angina attacks and prophylaxis (prevention) of angina.</p> Signup and view all the answers

List the common adverse effects of Nitrates.

<p>Hypotension (which can be significant), headache, and flushing.</p> Signup and view all the answers

Which of the following drugs are classified as Nitrates?

<p>Isosorbide Mononitrate (B), Nitroglycerin (C)</p> Signup and view all the answers

What is the brand name for Nitroglycerin?

<p>Nitrostat</p> Signup and view all the answers

What is the brand name for Isosorbide Mononitrate?

<p>Imdur</p> Signup and view all the answers

Describe the administration protocol for sublingual nitroglycerin during an acute angina attack.

<p>Give one sublingual tablet every 5 minutes for up to 3 doses. If chest pain persists after 3 doses, the patient or caregiver should seek immediate medical attention (e.g., call 911 or the doctor).</p> Signup and view all the answers

Nitroglycerin tablets should be replaced every year.

<p>False (B)</p> Signup and view all the answers

How do Beta Blockers work to manage cardiac conditions?

<p>Beta blockers slow the heart rate and cause vasodilation, which reduces the heart's workload and myocardial oxygen demand.</p> Signup and view all the answers

What are the clinical uses for Beta Blockers?

<p>They are used as maintenance therapy for angina, hypertension (high blood pressure), and Congestive Heart Failure (CHF).</p> Signup and view all the answers

Provide an example of a Beta Blocker drug.

<p>Metoprolol</p> Signup and view all the answers

What is the brand name for Metoprolol?

<p>Lopressor</p> Signup and view all the answers

How do Bile Acid Resins lower cholesterol?

<p>They bind with bile acids in the intestine, preventing their reabsorption. This forces the liver to use more cholesterol from the blood to synthesize new bile acids.</p> Signup and view all the answers

What is the primary use for Bile Acid Resins?

<p>Hyperlipidemia (high cholesterol levels).</p> Signup and view all the answers

What are common adverse effects associated with Bile Acid Resins?

<p>Constipation, general GI distress (bloating, gas), and potentially malabsorption of fat-soluble vitamins like Vitamin K.</p> Signup and view all the answers

Name a Bile Acid Resin drug.

<p>Cholestyramine</p> Signup and view all the answers

What is the brand name for Cholestyramine?

<p>Questran</p> Signup and view all the answers

What is the main indication for using HMG-CoA Reductase Inhibitors (Statins)?

<p>Hyperlipidemia (high cholesterol levels).</p> Signup and view all the answers

List potential adverse effects of HMG-CoA Reductase Inhibitors (Statins).

<p>Constipation, flatulence, and potential muscle toxicity (myopathy, rhabdomyolysis).</p> Signup and view all the answers

Provide an example of an HMG-CoA Reductase Inhibitor drug.

<p>Simvastatin</p> Signup and view all the answers

What is the brand name for Simvastatin?

<p>Zocor</p> Signup and view all the answers

What are the adverse effects associated with Fibric Acid Derivatives?

<p>Nausea, vomiting, diarrhea (N/V/D), and an increased risk of cholelithiasis (gallstones).</p> Signup and view all the answers

Which of the following are brand names for Fibric Acid Derivative drugs?

<p>Tricor (A), Lopid (B)</p> Signup and view all the answers

What is the generic name for Tricor?

<p>Fenofibrate</p> Signup and view all the answers

What is the generic name for Lopid?

<p>Gemfibrozil</p> Signup and view all the answers

What are the primary effects of Cardiotonics (like Digoxin)?

<p>They increase the force of myocardial contraction (positive inotropic effect) and slow the heart rate (negative chronotropic effect).</p> Signup and view all the answers

List common adverse reactions to Cardiotonics (Digoxin).

<p>Headache, weakness, drowsiness, visual disturbances (halos, color changes), arrhythmias, GI upset (nausea, vomiting, diarrhea), and anorexia.</p> Signup and view all the answers

What are key signs of Digoxin (Dig) toxicity?

<p>Visual disturbances (especially green/yellow halos), anorexia (a significant sign), nausea, vomiting, diarrhea, and hypokalemia (low potassium).</p> Signup and view all the answers

What is the antidote for Digoxin toxicity?

<p>Digibind (Digoxin Immune Fab)</p> Signup and view all the answers

Hypokalemia (low potassium) decreases the risk of digoxin toxicity.

<p>False (B)</p> Signup and view all the answers

What nursing intervention is crucial before administering any cardiotonic drug like Digoxin?

<p>Take the patient's apical pulse for a full minute.</p> Signup and view all the answers

How do Angiotensin-Converting Enzyme Inhibitors (ACEIs) lower blood pressure?

<p>They block the conversion of angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor, so blocking its formation leads to vasodilation and reduced blood pressure.</p> Signup and view all the answers

What are the main uses for ACE Inhibitors?

<p>Hypertension (high blood pressure) and heart failure.</p> Signup and view all the answers

What is a characteristic and common adverse effect of ACE Inhibitors?

<p>A persistent dry cough.</p> Signup and view all the answers

Which of the following drugs are ACE Inhibitors?

<p>Lisinopril (A)</p> Signup and view all the answers

What is the brand name for Benazepril?

<p>Lotensin</p> Signup and view all the answers

What is the brand name for Lisinopril?

<p>Zestril</p> Signup and view all the answers

What are the clinical applications of Calcium Channel Blockers?

<p>Hypertension, angina, and certain types of cardiac arrhythmias.</p> Signup and view all the answers

List common adverse effects of Calcium Channel Blockers.

<p>Peripheral edema (swelling in ankles/legs), headache, constipation, nasal congestion, hypotension, and bradycardia (especially with non-dihydropyridines like diltiazem).</p> Signup and view all the answers

Which of the following are examples of Calcium Channel Blocker drugs?

<p>Amlodipine (A), Diltiazem (D)</p> Signup and view all the answers

What is the brand name for Amlodipine?

<p>Norvasc</p> Signup and view all the answers

What is the brand name for Diltiazem?

<p>Cardizem</p> Signup and view all the answers

What conditions are commonly treated with Loop Diuretics?

<p>Hypertension (sometimes as first-line therapy), edema associated with conditions like Congestive Heart Failure (CHF), renal failure, or liver cirrhosis.</p> Signup and view all the answers

What is a common adverse effect patients should be monitored for when taking Loop Diuretics?

<p>Orthostatic hypotension (dizziness upon standing).</p> Signup and view all the answers

Identify the Loop Diuretic drugs from the list below.

<p>Furosemide (C), Bumetanide (D)</p> Signup and view all the answers

What is the brand name for Furosemide?

<p>Lasix</p> Signup and view all the answers

What is the brand name for Bumetanide?

<p>Bumex</p> Signup and view all the answers

What is the primary use for Centrally-Acting Antiadrenergic drugs?

<p>Hypertension.</p> Signup and view all the answers

Which of the following are Centrally-Acting Antiadrenergic drugs?

<p>Clonidine (B), Methyldopa (D)</p> Signup and view all the answers

What is the brand name for Methyldopa?

<p>Aldomet</p> Signup and view all the answers

What are the main uses for oral anticoagulants such as Warfarin?

<p>Prevention and treatment of Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE), and prevention of stroke-causing emboli in patients with Atrial Fibrillation (A-fib).</p> Signup and view all the answers

What is the primary adverse effect of oral anticoagulants like Warfarin?

<p>Bleeding.</p> Signup and view all the answers

What is the primary oral anticoagulant discussed that interferes with Vitamin K?

<p>Warfarin</p> Signup and view all the answers

What is the brand name for Warfarin?

<p>Coumadin</p> Signup and view all the answers

What laboratory tests are used to monitor Warfarin (Coumadin) therapy, and what are the typical target ranges?

<p>Prothrombin Time (PT) and International Normalized Ratio (INR). Target PT is typically 1.2-1.5 times the control value, and target INR is usually 2.0-3.0 (may be higher for specific indications like mechanical heart valves).</p> Signup and view all the answers

What is the antidote for Warfarin (Coumadin) overdose or excessive anticoagulation?

<p>Vitamin K (Phytonadione).</p> Signup and view all the answers

How do parenteral anticoagulants like Heparin work?

<p>Heparin potentiates the action of antithrombin III, which inactivates thrombin and Factor Xa, thus inhibiting the formation of fibrin clots.</p> Signup and view all the answers

What are the uses for parenteral anticoagulants like Heparin?

<p>Prevention and treatment of DVT and PE, prevention of emboli in A-fib (often as a bridge to warfarin), and maintaining the patency of IV catheters (low doses).</p> Signup and view all the answers

What is the main adverse effect of parenteral anticoagulants like Heparin?

<p>Bleeding.</p> Signup and view all the answers

What is the primary parenteral anticoagulant discussed?

<p>Heparin</p> Signup and view all the answers

What laboratory test is used to monitor therapeutic intravenous Heparin therapy, and what is the typical target range?

<p>Activated Partial Thromboplastin Time (aPTT or PTT). Target PTT is typically 1.5-2.5 times the control value.</p> Signup and view all the answers

Low Molecular Weight Heparin (LMWH) carries a higher risk of bleeding compared to unfractionated Heparin.

<p>False (B)</p> Signup and view all the answers

Name an example of a Low Molecular Weight Heparin (LMWH) drug.

<p>Enoxaparin</p> Signup and view all the answers

What is the brand name for Enoxaparin?

<p>Lovenox</p> Signup and view all the answers

Which of the following is a key nursing intervention when administering Low Molecular Weight Heparin (LMWH) like Enoxaparin?

<p>Do not expel the air bubble in the prefilled syringe (C)</p> Signup and view all the answers

What is the primary action of Disease-Modifying Antirheumatic Drugs (DMARDs)?

<p>They produce immunosuppression to slow down the progression of autoimmune diseases like rheumatoid arthritis.</p> Signup and view all the answers

What is the main use for Disease-Modifying Antirheumatic Drugs (DMARDs)?

<p>Rheumatoid arthritis (RA).</p> Signup and view all the answers

What are potential adverse effects associated with DMARDs?

<p>Increased risk of infection (due to immunosuppression), nausea, stomatitis (mouth sores), and alopecia (hair loss).</p> Signup and view all the answers

What laboratory test can be used to monitor disease activity and response to therapy in conditions treated with DMARDs?

<p>Erythrocyte Sedimentation Rate (ESR).</p> Signup and view all the answers

Which of these drugs are classified as DMARDs?

<p>Etanercept (B), Methotrexate (C), Adalimumab (D)</p> Signup and view all the answers

What is the brand name for Adalimumab?

<p>Humira</p> Signup and view all the answers

What is the brand name for Etanercept?

<p>Enbrel</p> Signup and view all the answers

What is the brand name for Methotrexate used in rheumatology?

<p>Rheumatrex</p> Signup and view all the answers

What are potential hematologic adverse effects of Methotrexate, and what monitoring is required?

<p>Thrombocytopenia (low platelets) and leukopenia (low white blood cells). Hematology (blood counts), liver function, and renal function tests should be monitored regularly (e.g., every 3 months).</p> Signup and view all the answers

How do Bisphosphonates work?

<p>They act primarily on bone tissue to inhibit osteoclast activity, thereby slowing down both normal and abnormal bone resorption (breakdown).</p> Signup and view all the answers

What are the primary uses for Bisphosphonates?

<p>Treatment and prevention of osteoporosis (especially postmenopausal) and management of hypercalcemia (high blood calcium levels), often associated with malignancy.</p> Signup and view all the answers

List common gastrointestinal adverse effects of oral Bisphosphonates.

<p>Acid regurgitation (heartburn), dysphagia (difficulty swallowing), esophagitis, nausea, and diarrhea.</p> Signup and view all the answers

Which of the following drugs are Bisphosphonates?

<p>Alendronate (A), Ibandronate (D)</p> Signup and view all the answers

What is the proposed mechanism of action for Nonsteroidal Anti-inflammatory Drugs (NSAIDs)?

<p>They are thought to inhibit the synthesis of prostaglandins by blocking cyclooxygenase (COX) enzymes.</p> Signup and view all the answers

Which of the following medications are classified as NSAIDs?

<p>Ibuprofen (A), Celecoxib (C), Naproxen (D)</p> Signup and view all the answers

What is the brand name for Ibuprofen?

<p>Motrin (also Advil)</p> Signup and view all the answers

What is the brand name for Celecoxib, and what specific contraindication does it have?

<p>Celebrex. It is contraindicated in patients with a known sulfa allergy.</p> Signup and view all the answers

What are the primary pharmacological actions of Salicylates (like Aspirin)?

<p>They inhibit prostaglandin synthesis, providing anti-inflammatory, analgesic (pain relief), and antipyretic (fever reduction) effects.</p> Signup and view all the answers

What are the therapeutic uses for Salicylates?

<p>Mild to moderate pain relief, reduction of inflammation, fever reduction, and, in low doses, prevention of cardiovascular events (like heart attack and stroke) due to antiplatelet effects.</p> Signup and view all the answers

What are significant adverse effects associated with Salicylates?

<p>GI ulcerations and bleeding, and tinnitus (ringing in the ears), which can be an early sign of ototoxicity (damage to the ear) or salicylate toxicity.</p> Signup and view all the answers

What is the primary example of a Salicylate drug?

<p>Aspirin</p> Signup and view all the answers

Which principle should guide IV site selection?

<p>Start distally on the non-dominant arm (B)</p> Signup and view all the answers

How often should peripheral IV sites typically be monitored and changed?

<p>Monitor the site frequently (e.g., every 1-2 hours) for complications. Change the site per facility protocol, which is often every 72-96 hours.</p> Signup and view all the answers

What is infiltration in the context of IV therapy?

<p>Infiltration occurs when IV fluid leaks from the vein into the surrounding subcutaneous tissue.</p> Signup and view all the answers

Which of the following are potential complications of IV therapy?

<p>Infection (A), Hematoma (B), Infiltration (C), Fluid overload (D)</p> Signup and view all the answers

List cardiovascular signs and symptoms associated with a venous air embolism.

<p>Hypotension (low blood pressure), weak thready pulse, chest pain, and jugular vein distention.</p> Signup and view all the answers

Describe the respiratory signs and symptoms that may indicate a venous air embolism.

<p>Dyspnea (shortness of breath), cyanosis (bluish discoloration), tachypnea (rapid breathing), expiratory wheezes, cough, pulmonary edema, decreased breath sounds, and potentially hemoptysis (coughing up blood).</p> Signup and view all the answers

What neurological changes might occur with a venous air embolism?

<p>Changes in mental status, confusion, coma, anxiousness, seizures, lightheadedness, and weakness.</p> Signup and view all the answers

How do nitrates improve oxygenated blood flow to the heart?

<p>Nitrates cause vasodilation, which widens blood vessels, thereby increasing oxygenated blood flow to the heart muscle.</p> Signup and view all the answers

List the common adverse effects associated with nitrate use.

<p>Hypotension (which can be significant), headache, and flushing.</p> Signup and view all the answers

Match the generic nitrate drug name to its brand name.

<p>Nitroglycerin = Nitrostat Isosorbide Mononitrate = Imdur Isosorbide Dinitrate = Isordil</p> Signup and view all the answers

Describe the instructions for using sublingual nitroglycerin during an acute angina attack.

<p>Take one tablet sublingually every 5 minutes for up to 3 doses. If chest pain persists after the third dose, seek immediate medical attention (call emergency services/doctor).</p> Signup and view all the answers

Nitroglycerin tablets lose potency over time and should be replaced every 3-6 months.

<p>True (A)</p> Signup and view all the answers

When applying a nitroglycerin patch, it's important to place the new patch in the exact same spot each day.

<p>False (B)</p> Signup and view all the answers

How do beta blockers help manage angina?

<p>Beta blockers slow the heart rate and cause vasodilation, which reduces the heart muscle's oxygen demand.</p> Signup and view all the answers

Besides angina, what other conditions are commonly treated with beta blockers?

<p>Hypertension and Congestive Heart Failure (CHF) (D)</p> Signup and view all the answers

Explain the mechanism of action for bile acid resins.

<p>Bile acid resins bind with bile acids in the intestines, preventing their reabsorption. This forces the liver to use more cholesterol from the blood to synthesize new bile acids, thus lowering blood cholesterol levels.</p> Signup and view all the answers

What are common adverse effects of bile acid resins?

<p>Constipation, general GI distress, and potentially malabsorption of vitamin K.</p> Signup and view all the answers

How do HMG-CoA reductase inhibitors (statins) lower cholesterol?

<p>They inhibit HMG-CoA reductase, an enzyme essential for the liver's production of cholesterol. They may also promote the breakdown of existing cholesterol.</p> Signup and view all the answers

What is a notable adverse effect of HMG-CoA reductase inhibitors that involves the muscles?

<p>Muscle toxicity (myopathy or rhabdomyolysis).</p> Signup and view all the answers

Describe the mechanism of action of fibric acid derivatives.

<p>They stimulate the liver to break down VLDL (Very Low-Density Lipoprotein) and LDL (Low-Density Lipoprotein) and increase the excretion of cholesterol in the feces.</p> Signup and view all the answers

What are potential adverse effects of fibric acid derivatives?

<p>Nausea, vomiting, diarrhea (N/V/D), and cholelithiasis (gallstones).</p> Signup and view all the answers

Match the fibric acid derivative brand name to its generic name.

<p>Tricor = Fenofibrate Lopid = Gemfibrozil</p> Signup and view all the answers

What is often the first sign of digoxin toxicity in adults?

<p>Nausea is usually the first sign of toxicity in adults.</p> Signup and view all the answers

List key signs and symptoms specifically associated with digoxin toxicity.

<p>Green/yellow halos and visual disturbances, anorexia (a significant indicator), N/V/D, and arrhythmias. Hypokalemia (low potassium) increases the risk.</p> Signup and view all the answers

Hypokalemia (low potassium levels) predisposes a patient to digoxin toxicity.

<p>True (A)</p> Signup and view all the answers

How do ACE inhibitors (ACEIs) work to lower blood pressure?

<p>They block the conversion of angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor, so blocking its formation prevents vasoconstriction and leads to lower blood pressure.</p> Signup and view all the answers

What is a common and distinctive adverse effect associated with ACE inhibitors?

<p>A persistent dry cough.</p> Signup and view all the answers

Match the generic ACE inhibitor drug name to its brand name.

<p>Benazepril = Lotensin Lisinopril = Zestril Captopril = Capoten</p> Signup and view all the answers

Describe the mechanism of action for calcium channel blockers (CCBs).

<p>They block the movement of calcium ions across cell membranes, particularly in vascular smooth muscle and cardiac cells. This leads to vasodilation, slows the heart rate, and decreases the force of heart contractions.</p> Signup and view all the answers

What are the main uses for calcium channel blockers?

<p>Hypertension, angina, and treating certain types of arrhythmias (antiarrhythmic).</p> Signup and view all the answers

Match the generic calcium channel blocker drug name to its brand name.

<p>Amlodipine = Norvasc Diltiazem = Cardizem</p> Signup and view all the answers

How do loop diuretics work?

<p>They inhibit the reabsorption of sodium and chloride primarily in the ascending limb of the Loop of Henle in the kidneys.</p> Signup and view all the answers

What is a common cardiovascular adverse effect associated with loop diuretics?

<p>Orthostatic hypotension (a drop in blood pressure upon standing).</p> Signup and view all the answers

Match the generic loop diuretic drug name to its brand name.

<p>Furosemide = Lasix Bumetanide = Bumex</p> Signup and view all the answers

What is the mechanism of action for centrally-acting antiadrenergic drugs?

<p>They stimulate alpha-2 adrenergic receptors in the central nervous system, which reduces sympathetic outflow from the brain, leading to vasodilation and decreased heart rate.</p> Signup and view all the answers

Match the generic centrally-acting antiadrenergic drug name to its brand name.

<p>Clonidine = Catapres Methyldopa = Aldomet</p> Signup and view all the answers

How do oral anticoagulants like Warfarin work?

<p>They interfere with the synthesis of Vitamin K-dependent clotting factors in the liver.</p> Signup and view all the answers

What are the main indications for using oral anticoagulants such as Warfarin (Coumadin)?

<p>Prevention and treatment of Deep Vein Thrombosis (DVT), and prevention and treatment of emboli (clots) resulting from Atrial Fibrillation (A-fib).</p> Signup and view all the answers

What is the primary adverse effect of Warfarin (Coumadin)?

<p>Bleeding.</p> Signup and view all the answers

What lab tests monitor Warfarin therapy, and what are the typical target therapeutic ranges?

<p>Prothrombin Time (PT) and International Normalized Ratio (INR). Therapeutic ranges are typically PT: 1.2-1.5 times control, and INR: 2-3.</p> Signup and view all the answers

What is the antidote for Warfarin (Coumadin) overdose?

<p>Vitamin K.</p> Signup and view all the answers

List the uses for parenteral anticoagulants like Heparin.

<p>Prevention and treatment of DVT, prevention and treatment of A-fib induced emboli, and maintaining the patency of intravenous (IV) catheters.</p> Signup and view all the answers

What is the main adverse effect associated with Heparin therapy?

<p>Bleeding.</p> Signup and view all the answers

What lab test is primarily used to monitor Heparin therapy (standard unfractionated heparin), and what is the typical therapeutic range?

<p>Partial Thromboplastin Time (PTT) or activated Partial Thromboplastin Time (aPTT). The therapeutic range is typically 1.5-2.5 times the control value.</p> Signup and view all the answers

Low Molecular Weight Heparin (LMWH) is associated with a higher risk of bleeding compared to standard unfractionated heparin.

<p>False (B)</p> Signup and view all the answers

Which instruction is correct regarding the subcutaneous administration of Low Molecular Weight Heparin (LMWH) like Enoxaparin (Lovenox)?

<p>Administer subcutaneously into the abdomen, rotating sites, and do not aspirate or massage. (C)</p> Signup and view all the answers

What is the primary mechanism of action for Disease-Modifying Antirheumatic Drugs (DMARDs)?

<p>DMARDs produce immunosuppression.</p> Signup and view all the answers

What laboratory test can help monitor the level of inflammation often treated by DMARDs?

<p>Erythrocyte Sedimentation Rate (ESR).</p> Signup and view all the answers

Match the generic DMARD name to its brand name.

<p>Adalimumab = Humira Etanercept = Enbrel Methotrexate = Rheumatrex</p> Signup and view all the answers

What are potential hematologic adverse effects of Methotrexate?

<p>Thrombocytopenia (low platelets) and leukopenia (low white blood cells).</p> Signup and view all the answers

How frequently should hematology, liver, and renal function tests be performed for patients taking Methotrexate?

<p>Approximately every 3 months.</p> Signup and view all the answers

What conditions are bisphosphonates used to treat?

<p>Osteoporosis (to prevent fractures) and hypercalcemia (high calcium levels, often related to malignancy).</p> Signup and view all the answers

List common adverse effects associated with oral bisphosphonates.

<p>Acid regurgitation (heartburn), dysphagia (difficulty swallowing), nausea, and diarrhea.</p> Signup and view all the answers

Which of the following are examples of bisphosphonate drugs?

<p>Alendronate and Ibandronate (D)</p> Signup and view all the answers

List common adverse effects of NSAIDs.

<p>Nausea, vomiting, epigastric pain, bloating, GI bleeding, and potentially reducing the effectiveness of antihypertensive medications.</p> Signup and view all the answers

Celecoxib (Celebrex) is contraindicated in patients with an allergy to which type of medication?

<p>Sulfa drugs (sulfonamides).</p> Signup and view all the answers

What are the main therapeutic actions of salicylates like Aspirin?

<p>Inhibition of prostaglandins, resulting in anti-inflammatory, analgesic (pain relief), and antipyretic (fever reduction) effects.</p> Signup and view all the answers

What are the uses for salicylates such as Aspirin?

<p>Mild to moderate pain relief, reducing inflammation, and, in low doses, prevention of cardiovascular events (like heart attack and stroke).</p> Signup and view all the answers

What are two significant potential adverse effects of salicylates (e.g., Aspirin)?

<p>GI ulcerations/bleeding and tinnitus (ringing in the ears), which can be a sign of ototoxicity.</p> Signup and view all the answers

When initiating IV therapy, the nurse should attempt insertions on the patient's dominant side first.

<p>False (B)</p> Signup and view all the answers

How frequently should a peripheral IV insertion site typically be monitored?

<p>At least every 2 hours.</p> Signup and view all the answers

List potential complications associated with intravenous (IV) therapy.

<p>Infiltration (fluid leaking into tissue), phlebitis (vein inflammation), infection (local or systemic), fluid overload, venous vasospasm, hematoma (bruising), and emboli (air or catheter fragment).</p> Signup and view all the answers

Which set of signs and symptoms is most characteristic of a venous air embolism?

<p>Hypotension, weak/thready pulse, dyspnea, cyanosis, chest pain, altered mental status (B)</p> Signup and view all the answers

Flashcards

Nitrates

Vasodilates, increasing oxygenated blood flow to the heart.

Nitrates Uses

Used for acute angina and prophylaxis.

Nitrates Adverse Effects

Can cause hypotension, headache, and flushing.

Nitrates Drugs

Includes Nitroglycerin, Isosorbide Mononitrate, Isosorbide Dinitrate & patches.

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Nitroglycerin

Also known as Nitrostat.

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Isosorbide Mononitrate

Also known as Imdur.

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Isosorbide Dinitrate

Also known as Isordil.

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Nitrates Patient Teaching

Administer sublingual nitroglycerin every 5 minutes x 3 rounds. Monitor vital signs. Keep nitro with you at all times.

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Beta Blockers

Slows heart rate and vasodilates, reducing myocardial O2 demand.

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Beta Blocker Uses

Used for maintenance of angina, hypertension, and CHF.

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Beta Blockers Adverse Effects

Can cause bradycardia, hypotension, and bronchospasm (nonselective).

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Beta Blocker Drugs

Example drug: Metoprolol.

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Metoprolol

Also known as Lopressor.

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Bile Acid Resins

Binds with bile acids, preventing their use; liver uses more cholesterol to make bile.

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Bile Acid Resins Uses

Used for hyperlipidemia.

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Bile Acid Resins Adverse Effects

Can cause constipation, GI distress, and malabsorption of vitamin K.

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Bile Acid Resins Drugs

Example drug: Cholestyramine.

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Cholestyramine

Also known as Questran.

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HMG-CoA Reductase Inhibitors

Inhibit the manufacture or promote breakdown of cholesterol.

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HMG-CoA Reductase Inhibitors Uses

Used for hyperlipidemia.

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HMG-CoA Reductase Inhibitors Adverse Effects

Can cause constipation, flatulence, and muscle toxicity.

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HMG-CoA Reductase Inhibitor Drugs

Example drug: Simvastatin.

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Simvastatin

Also known as Zocor.

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Fibric Acid Derivatives

Stimulates liver to breakdown VLDL and LDL, increases excretion of cholesterol in feces.

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Fibric Acid Derivatives Adverse Effects

Can cause N/V/D and cholelithiasis.

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Fibric Acid Derivatives Drugs

Examples: Tricor and Lopid.

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Tricor

Also known as Fenofibrate.

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Lopid

Also known as Gemfibrozil.

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Cardiotonics

Increase force of contraction of myocardium and slows heart rate.

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Cardiotonics Adverse Reactions

Can cause headache, weakness, drowsiness, visual disturbances, arrhythmias, and GI upset.

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Cardiotonics: Dig Toxicity

Green/yellow halos, anorexia, N/V/D, hypokalemia.

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Cardiotonics Nursing Interventions

Antidote: Digibind. therapeutic level-0.8-2.0. Apical pulse important.

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Antihypertensives (ACEIs)

Block conversion of angiotensin I to angiotensin II, preventing vasoconstriction.

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Antihypertensives Uses

Used for hypertension and heart failure.

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Antihypertensives Adverse Effects

Can cause cough, hypotension, dizziness, nausea, and orthostatic hypotension.

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Antihypertensives Drugs

Examples: Benazepril, Lisinopril, Captopril.

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Benazepril

Also known as Lotensin.

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Lisinopril

Also known as Zestril.

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Captopril

Also known as Capoten.

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Calcium Channel Blockers

Block movement of calcium across cell membranes producing vasodilation.

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Calcium Channel Blockers Uses

Used for hypertension, angina, and antiarrhythmic purposes.

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Calcium Channel Blockers Adverse Effects

Can cause peripheral edema, headache, constipation, nasal congestion, hypotension, and bradycardia.

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Calcium Channel Blockers Drugs

Examples: Amlodipine, Diltiazem.

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Amlodipine

Also known as Norvasc.

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Diltiazem

Also known as Cardizem.

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Loop Diuretics

Inhibits the reabsorption of sodium and chloride in loop of Henle.

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Loop Diuretics Uses

Used for hypertension and edema due to renal failure or cirrhosis.

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Loop Diuretics Adverse Effects

Can cause orthostatic hypotension.

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Loop Diuretics Drugs

Examples: Furosemide, Bumetanide.

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Furosemide

Also known as Lasix.

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Bumetanide

Also known as Bumex.

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Study Notes

Nitrates

  • Act as vasodilators, increasing oxygenated blood flow to the heart.
  • Used for acute angina and prophylaxis.
  • Adverse effects include hypotension, headache, and flushing.
  • Drug examples are Nitroglycerin (Nitrostat), Isosorbide Mononitrate (Imdur), Isosorbide Dinitrate (Isordil), and Nitrates in patch form.

Nitrates: Patient Teaching

  • For acute angina, administer sublingual nitroglycerin every 5 minutes for up to 3 doses; if pain persists, seek medical attention.
  • Monitor vital signs and document chest pain.
  • Apical pulse should be taken with any cardiac drug.
  • Ensure patient safety due to potential hypotensive effects.
  • Nitroglycerin should be replaced every 3-6 months and stored in a brown bottle.
  • Patients should rise slowly from lying or sitting positions.
  • Nitroglycerin should cause a tingling or stinging sensation when used.
  • Patch sites should be rotated, and old patches removed.
  • Patients should carry nitroglycerin at all times and use it prophylactically before stress-inducing activities.

Beta Blockers

  • Slow heart rate and cause vasodilation, reducing myocardial oxygen demand.
  • Used for angina maintenance, hypertension, and CHF.
  • Can cause bradycardia, hypotension, and bronchospasm with nonselective types.
  • Metoprolol (Lopressor) is an example of a beta-blocker drug.

Bile Acid Resins

  • Bind with bile acids to prevent their use, prompting the liver to use more cholesterol to produce bile.
  • Used to treat hyperlipidemia.
  • Adverse effects include constipation, GI distress, and malabsorption of vitamin K.
  • Cholestyramine (Questran) is a bile acid resin medication.

HMG-CoA Reductase Inhibitors

  • Inhibit cholesterol production or promote its breakdown.
  • Treat hyperlipidemia.
  • Adverse effects can include constipation, flatulence, and muscle toxicity.
  • Simvastatin (Zocor) is an example.

Fibric Acid Derivatives

  • Stimulate the liver to break down VLDL and LDL, and increase cholesterol excretion in feces.
  • Adverse effects include N/V/D and cholelithiasis.
  • Examples include Fenofibrate (Tricor) and Gemfibrozil (Lopid).

Cardiotonics

  • Increase the force of myocardial contraction and slow heart rate.
  • Can cause headache, weakness, drowsiness, visual disturbances, arrhythmias, and GI upset.
  • Anorexia and nausea are often the first signs of toxicity in adults.
  • GI or CNS signs often indicate adverse effects.

Cardiotonics: Dig Toxicity

  • Manifests as green/yellow halos in vision, anorexia, N/V/D, and hypokalemia.

Cardiotonics: Nursing Interventions

  • Digibind is the antidote for Dig toxicity.
  • The therapeutic level is 0.8-2.0; levels greater than 2.0 are considered toxic.
  • Monitor apical pulse.
  • Hypokalemia predisposes patients to Dig toxicity.

Antihypertensives (ACEIs)

  • Block the conversion of angiotensin I to angiotensin II, preventing vasoconstriction.
  • Used for hypertension and heart failure.
  • Adverse effects include cough, hypotension, dizziness, nausea, and orthostatic hypotension.
  • Examples include Benazepril (Lotensin), Lisinopril (Zestril), and Captopril (Capoten).

Calcium Channel Blockers

  • Block calcium movement across cell membranes, causing vasodilation; slows heart rate and decreases contractility.
  • Used for hypertension, angina, and as an antiarrhythmic.
  • Adverse effects include peripheral edema, headache, constipation, nasal congestion, hypotension, and bradycardia.
  • Examples of drugs include Amlodipine (Norvasc) and Diltiazem (Cardizem).

Loop Diuretics

  • Inhibit sodium and chloride reabsorption in the loop of Henle.
  • Used for hypertension and edema related to renal failure, cirrhosis, or CHF.
  • Orthostatic hypotension is a notable adverse effect.
  • Examples are Furosemide (Lasix) and Bumetanide (Bumex).

Centrally-Acting Antiadrenergics

  • Block alpha-adrenergic receptors, producing vasodilation.
  • Used for hypertension.
  • Adverse effects include drowsiness, sedation, dry mouth, constipation, and syncope.
  • Drugs include Clonidine (Catapres) and Methyldopa (Aldomet).

Anticoagulants-Oral

  • Interfere with Vitamin K-dependent clotting factors.
  • Used for the prevention and treatment of DVT and A-fib-induced emboli.
  • Bleeding is a primary adverse effect.
  • Warfarin (Coumadin) is a common oral anticoagulant.

Anticoagulants-Oral: Nursing Interventions

  • Monitor PT/INR results before administering Warfarin (Coumadin).
  • PT target is 1.2-1.5, and INR target is 2-3.
  • Vitamin K is the antidote.

Anticoagulants-Parenteral

  • Inhibit the formation of fibrin clots.
  • Used for prevention and treatment of DVT and A-fib-induced emboli.
  • Heparin is used to maintain patency of IV catheters.
  • Bleeding is a major adverse effect.
  • Heparin is a common parenteral anticoagulant.

Anticoagulants-Parenteral: Nursing Interventions

  • Monitor PTT results before administering Heparin.
  • Heparin PTT target is 1.5-2.5.
  • Protamine sulfate is the antidote.

Low Molecular Weight Heparin (LMWH)

  • Bleeding is less likely compared to heparin.
  • Enoxaparin (Lovenox) is a common LMWH.

Low Molecular Weight Heparin (LMWH): Nursing Interventions

  • Administered subcutaneously, without expelling the air bubble.
  • Do not aspirate or massage the injection site.
  • Inject subcutaneously in the abdomen, rotating sites.

DMARDs

  • Produce immunosuppression.
  • Used for rheumatoid arthritis.
  • Adverse effects include signs/symptoms of infection, nausea, stomatitis, and alopecia.
  • Monitor Erythrocyte Sedimentation Rate (ESR).
  • Examples include Adalimumab (Humira), Etanercept (Enbrel), and Methotrexate (Rheumatrex).

DMARDs: Methotrexate

  • Can cause thrombocytopenia and leukopenia.
  • Hematology, liver, and renal function should be monitored every 3 months.

Bisphosphonates

  • Act on bone to inhibit normal and abnormal bone resorption.
  • Used for osteoporosis and hypercalcemia.
  • Adverse effects include acid regurgitation, dysphagia, N/D.
  • Alendronate and Ibandronate are examples.

NSAIDs

  • Inhibit prostaglandin synthesis.
  • Used for chronic pain and fever.
  • Adverse effects include N/V, epigastric pain, bloating, GI bleeding, and potential ineffectiveness of hypertension medications.
  • Common NSAIDs include Ibuprofen (Motrin), Naproxen (Aleve), and Celecoxib (Celebrex).
  • Celecoxib (Celebrex) is contraindicated in patients with sulfa allergies.

Salicylates

  • Inhibit prostaglandins, acting as anti-inflammatories and analgesics.
  • Used for mild to moderate pain and inflammation; low doses are used for cardiovascular disorders.
  • Can cause GI ulcerations/bleeding and tinnitus (ototoxicity).
  • Aspirin (Ecotrin) is a common salicylate.

IV Therapy Nursing Interventions

  • Wash hands/wear gloves.
  • Start distally and work proximally.
  • Use the non-dominant side first.
  • Avoid sites on the side of trauma, stroke, surgery, etc.
  • Monitor the site every 2 hours.
  • Change the site per protocol, usually every 72 hours.
  • Use the smallest catheter necessary.
  • Use aseptic technique when starting and accessing IVs.
  • Flush intermittent needle therapy (INTs) before and after accessing (at least every 8 hours).
  • Change fluids every 24 hours and tubings every 72 hours (and with site changes).
  • Monitor for complications.

IV Therapy Complications

  • Infiltration
  • Fluid overload
  • Infection (localized and systemic)
  • Venous vasospasm
  • Emboli
  • Hematoma

Venous Air Embolism: Signs and Symptoms

Cardiovascular

  • Hypotension
  • Weak, thready pulse
  • Chest pain
  • Jugular vein distention

Respiratory

  • Dyspnea
  • Cyanosis
  • Tachypnea
  • Expiratory wheezes
  • Cough
  • Pulmonary edema
  • Decreased breath sounds on the affected side
  • Hemoptysis

Neurological

  • Changes in mental status
  • Confusion
  • Coma
  • Anxiousness
  • Seizures
  • Lightheadedness
  • Weakness

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