Von Willebrand Disease (VWD) questions

Which of the following is NOT a known function of von Willebrand factor (vWF)?

A patient presents with a history of easy bruising, frequent nosebleeds, and heavy menstrual bleeding. These symptoms are most indicative of which bleeding disorder?

A patient with type O blood is being evaluated for a bleeding disorder. Which of the following statements is most accurate regarding the interpretation of their vWF levels?

Desmopressin (DDAVP) is a common treatment for some types of Von Willebrand Disease (VWD). What is the primary mechanism of action of Desmopressin in treating VWD?

In which type of Von Willebrand Disease (VWD) is agarose gel electrophoresis least likely to detect any vWF multimers?

Which type of VWD is characterized by hyperfunctional platelet binding?

A patient diagnosed with aortic stenosis develops acquired Von Willebrand Disease (VWD). Which pathophysiological mechanism is MOST likely responsible for the development of VWD in this scenario?

A 25-year-old female patient with a history of menorrhagia is suspected of having a bleeding disorder. Initial lab results show normal platelet count, PT, and INR, but prolonged PTT. Further testing reveals decreased levels of vWF antigen and activity. Which of the following genetic inheritance patterns would make Type 3 VWD most likely in this patient?

During an investigation into a qualitative VWD, a lab technician performs an in vitro platelet aggregation study. They observe that ristocetin-induced platelet aggregation is significantly enhanced. Which subtype of VWD is most likely indicated by this finding?

A researcher is investigating novel therapeutic targets for VWD. They hypothesize that inhibiting a specific enzyme could prevent the degradation of vWF multimers under high shear stress conditions. Which of the following enzymes would be the MOST rational target for this therapeutic intervention?

What is the approximate prevalence of von Willebrand Disease (VWD) in the UK population?

Which of the following is the primary function of von Willebrand Factor (vWF)?

Which of the following inheritance patterns is MOST commonly associated with VWD?

A patient with a known bleeding disorder requires a tooth extraction. Which local haemostatic measure is LEAST appropriate for managing bleeding risk?

In a patient with VWD undergoing a minor surgical procedure, what is the generally accepted minimum platelet count to proceed safely, assuming no other complications?

Which of the following best describes the underlying mechanism of Factor V Leiden thrombophilia?

A patient with acquired VWD secondary to liver disease is scheduled for a dental extraction. Which of the following coagulation factors is MOST likely to be affected due to the liver dysfunction?

What is the primary reason NSAIDs are contraindicated in patients with inherited bleeding disorders?

A patient on DOACs requires flap-raising procedures. According to SDCEP guidelines, this falls under which risk category for bleeding?

A researcher is investigating a novel treatment for VWD Type 3. The therapeutic strategy aims to enhance the half-life of endogenous Factor VIII. Which of the following mechanisms would be MOST directly relevant to this therapeutic approach?

What is the most prevalent inherited bleeding disorder in the UK population?

Von Willebrand Factor (vWF) is primarily found in which of the following locations within the body?

In Type 2 Von Willebrand Disease (VWD), what is the primary characteristic of the von Willebrand Factor (vWF) protein?

Which of the following best describes the inheritance pattern most commonly associated with von Willebrand Disease (VWD)?

A patient with von Willebrand Disease (VWD) is scheduled for a minor tooth extraction. Which local haemostatic agent is MOST appropriate for use in managing post-extraction bleeding?

Why are non-steroidal anti-inflammatory drugs (NSAIDs) generally contraindicated in patients with inherited bleeding disorders like von Willebrand Disease (VWD)?

In the context of dental procedures for patients on Direct Oral Anticoagulants (DOACs) as per SDCEP guidelines, which of the following procedures is classified as carrying a 'higher risk of bleeding'?

A patient with acquired von Willebrand Disease (VWD) secondary to severe liver disease is being evaluated. Dysfunction of the liver in this context MOST directly impacts which aspect of coagulation leading to acquired VWD?

A dental practitioner is considering treating a patient with known Type 3 Von Willebrand Disease (VWD). Which of the following factors is the MOST critical to ascertain prior to undertaking even a minimally invasive procedure, such as a single tooth extraction?

In Factor V Leiden thrombophilia, the mutated Factor V protein exhibits resistance to inactivation by Activated Protein C (APC). Considering the role of Protein C in the coagulation cascade, what is the MOST direct consequence of this resistance on haemostasis?