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Questions and Answers
What is the prevalence of von Willebrand disease?
What is the prevalence of von Willebrand disease?
What role does von Willebrand factor play in the body?
What role does von Willebrand factor play in the body?
Which receptor does von Willebrand factor interact with on platelets?
Which receptor does von Willebrand factor interact with on platelets?
What is a common clinical manifestation of von Willebrand disease?
What is a common clinical manifestation of von Willebrand disease?
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Which of the following does NOT describe a symptom of von Willebrand disease?
Which of the following does NOT describe a symptom of von Willebrand disease?
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Von Willebrand factor is involved in which of the following diseases?
Von Willebrand factor is involved in which of the following diseases?
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Study Notes
Von Willebrand Disease
- Von Willebrand disease (VWD) is the most common congenital bleeding disorder, with a prevalence of 1% to 2%.
- It's a family of disorders, caused by a quantitative and/or qualitative defect of von Willebrand factor (VWF).
- VWF is a blood glycoprotein crucial for hemostasis, particularly platelet adhesion.
- VWF is deficient or defective in VWD, impacting many other conditions, including thrombotic thrombocytopenic purpura, Heyde's syndrome, and possible hemolytic-uremic syndrome.
- VWF is vital for both primary and secondary hemostasis.
- It promotes platelet adhesion after vascular injury by interacting with the glycoprotein Ib receptor on platelets.
- Symptoms can vary, ranging from asymptomatic to various bleeding manifestations.
- Common clinical manifestations include:
- Mucocutaneous bleeding (e.g., nosebleeds (epistaxis), bleeding gums with minor trauma.
- Menorrhagia (heavy menstrual bleeding).
- Easy bruising.
- Postoperative bleeding.
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Description
This quiz delves into von Willebrand disease (VWD), the most common congenital bleeding disorder. Learn about its causes, symptoms, and the crucial role of von Willebrand factor in hemostasis. Understand the various clinical manifestations associated with VWD.
