30 Questions
What is the classification property of a virus genome?
Genetic material (DNA or RNA)
How do orthomyxoviruses and paramyxoviruses attach to cells during adsorption?
By glycoprotein spikes
Which type of DNA virus can exist in a circular form?
Double-stranded circular
What process often follows penetration in viral replication?
Uncoating
Why do viral populations not grow through cell division?
They use host cell machinery for replication
What type of inclusion bodies are typically seen in cells infected with herpesvirus?
Nuclear inclusion bodies
During viral replication, where do virions enter the host cell through?
Receptor-mediated endocytosis
What is the diagnostic significance of the presence of inclusion bodies in viral infections?
Inclusion bodies are only found in some viral infections and can aid diagnosis
Which of the following is the most accurate statement about the Negri body?
The Negri body is pathognomonic for rabies virus infection
Which of the following is the most accurate statement about varicella (chickenpox)?
Varicella is a mild, highly contagious disease primarily affecting children
Which of the following best describes the cytopathology of herpesviruses?
Herpesviruses cause the formation of multinucleated giant cells
Which of the following is the most accurate statement about the diagnostic significance of inclusion bodies in viral infections?
Inclusion bodies can be useful for the diagnosis of some viral infections, but their presence is not always specific
Which disease is characterized by a rash limited to the skin innervated by a single sensory ganglion?
Zoster (shingles)
What is the reactivated form of an earlier varicella infection?
Shingles (Zoster)
Which virus causes chickenpox in childhood and shingles later in life?
Varicella-Zoster virus
What is the largest genome of all herpes viruses?
Cytomegalovirus
Which virus has transformation of B cells as one of its associated diseases?
Epstein-Barr virus
Which virus can only replicate in human cells and form multinucleated cells with staining inclusions?
Cytomegalovirus
What is the approximate range of the replication cycle length for herpesviruses?
18 to 70 hours
Which of the following is NOT mentioned as a way herpesviruses evade the immune system?
Inhibiting the production of antibodies against the virus
What stimuli can reactivate the virus from its latent state?
Axonal injury, fever, physical or emotional stress, and exposure to ultraviolet light
After reactivation, where does the virus replicate?
At the skin or mucous membranes
What is true about recurrent herpesvirus infections, even in the presence of host immunity?
They are less extensive and less severe than primary infections
What is a common manifestation of recurrent HSV-1 infection?
Cold sores (fever blisters) near the lip
Which statement about the herpesvirus entry into host cells is correct?
The virus binds to specific cellular receptors via envelope glycoproteins and fuses with the cell membrane.
What is the role of cellular RNA polymerase II in the herpesvirus replication cycle?
It transcribes the viral DNA throughout the replication cycle with the help of viral factors.
Which step in the herpesvirus replication cycle involves the formation of a circular DNA molecule?
Release of viral DNA from the capsid upon entry into the host cell nucleus.
What is the final step in the herpesvirus replication cycle before the release of new virus particles?
Transport of nucleocapsids to the cell surface through vesicular movement.
Which herpesvirus is associated with Kaposi's sarcoma, a type of cancer?
Kaposi's sarcoma-associated herpesvirus (KSHV or HHV-8)
Which cell type is primarily targeted by Kaposi's sarcoma-associated herpesvirus (KSHV)?
Monocytes and lymphocytes
Learn about the classification of virus genomes as DNA or RNA, and the various properties of DNA and RNA viruses. Explore the different stages involved in viral replication.
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