Virus Replication: Genome Classification and Replication Steps

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Questions and Answers

What is the classification property of a virus genome?

  • Method of replication
  • Genetic material (DNA or RNA) (correct)
  • Type of host cell
  • Number of strands

How do orthomyxoviruses and paramyxoviruses attach to cells during adsorption?

  • Through the viral genome
  • Via nuclear membrane fusion
  • Through receptor-mediated endocytosis
  • By glycoprotein spikes (correct)

Which type of DNA virus can exist in a circular form?

  • Single-stranded linear
  • Double-stranded circular (correct)
  • Double-stranded linear
  • Single-stranded circular

What process often follows penetration in viral replication?

<p>Uncoating (D)</p> Signup and view all the answers

Why do viral populations not grow through cell division?

<p>They use host cell machinery for replication (A)</p> Signup and view all the answers

What type of inclusion bodies are typically seen in cells infected with herpesvirus?

<p>Nuclear inclusion bodies (A)</p> Signup and view all the answers

During viral replication, where do virions enter the host cell through?

<p>Receptor-mediated endocytosis (D)</p> Signup and view all the answers

What is the diagnostic significance of the presence of inclusion bodies in viral infections?

<p>Inclusion bodies are only found in some viral infections and can aid diagnosis (C)</p> Signup and view all the answers

Which of the following is the most accurate statement about the Negri body?

<p>The Negri body is pathognomonic for rabies virus infection (B)</p> Signup and view all the answers

Which of the following is the most accurate statement about varicella (chickenpox)?

<p>Varicella is a mild, highly contagious disease primarily affecting children (C)</p> Signup and view all the answers

Which of the following best describes the cytopathology of herpesviruses?

<p>Herpesviruses cause the formation of multinucleated giant cells (B)</p> Signup and view all the answers

Which of the following is the most accurate statement about the diagnostic significance of inclusion bodies in viral infections?

<p>Inclusion bodies can be useful for the diagnosis of some viral infections, but their presence is not always specific (D)</p> Signup and view all the answers

Which disease is characterized by a rash limited to the skin innervated by a single sensory ganglion?

<p>Zoster (shingles) (C)</p> Signup and view all the answers

What is the reactivated form of an earlier varicella infection?

<p>Shingles (Zoster) (D)</p> Signup and view all the answers

Which virus causes chickenpox in childhood and shingles later in life?

<p>Varicella-Zoster virus (B)</p> Signup and view all the answers

What is the largest genome of all herpes viruses?

<p>Cytomegalovirus (B)</p> Signup and view all the answers

Which virus has transformation of B cells as one of its associated diseases?

<p>Epstein-Barr virus (B)</p> Signup and view all the answers

Which virus can only replicate in human cells and form multinucleated cells with staining inclusions?

<p>Cytomegalovirus (A)</p> Signup and view all the answers

What is the approximate range of the replication cycle length for herpesviruses?

<p>18 to 70 hours (C)</p> Signup and view all the answers

Which of the following is NOT mentioned as a way herpesviruses evade the immune system?

<p>Inhibiting the production of antibodies against the virus (D)</p> Signup and view all the answers

What stimuli can reactivate the virus from its latent state?

<p>Axonal injury, fever, physical or emotional stress, and exposure to ultraviolet light (A)</p> Signup and view all the answers

After reactivation, where does the virus replicate?

<p>At the skin or mucous membranes (D)</p> Signup and view all the answers

What is true about recurrent herpesvirus infections, even in the presence of host immunity?

<p>They are less extensive and less severe than primary infections (B)</p> Signup and view all the answers

What is a common manifestation of recurrent HSV-1 infection?

<p>Cold sores (fever blisters) near the lip (D)</p> Signup and view all the answers

Which statement about the herpesvirus entry into host cells is correct?

<p>The virus binds to specific cellular receptors via envelope glycoproteins and fuses with the cell membrane. (D)</p> Signup and view all the answers

What is the role of cellular RNA polymerase II in the herpesvirus replication cycle?

<p>It transcribes the viral DNA throughout the replication cycle with the help of viral factors. (D)</p> Signup and view all the answers

Which step in the herpesvirus replication cycle involves the formation of a circular DNA molecule?

<p>Release of viral DNA from the capsid upon entry into the host cell nucleus. (C)</p> Signup and view all the answers

What is the final step in the herpesvirus replication cycle before the release of new virus particles?

<p>Transport of nucleocapsids to the cell surface through vesicular movement. (A)</p> Signup and view all the answers

Which herpesvirus is associated with Kaposi's sarcoma, a type of cancer?

<p>Kaposi's sarcoma-associated herpesvirus (KSHV or HHV-8) (D)</p> Signup and view all the answers

Which cell type is primarily targeted by Kaposi's sarcoma-associated herpesvirus (KSHV)?

<p>Monocytes and lymphocytes (C)</p> Signup and view all the answers

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