Podcast
Questions and Answers
What is the common mechanism for virus entry that does not require specific virus proteins beyond those involved in receptor binding?
What is the common mechanism for virus entry that does not require specific virus proteins beyond those involved in receptor binding?
- Fusion
- Receptor binding
- Uncoating
- Endocytosis (correct)
What is the process by which the virus sheds its outer coat to release its genetic material into the host cell?
What is the process by which the virus sheds its outer coat to release its genetic material into the host cell?
- Uncoating (correct)
- Receptor binding
- Fusion
- Endocytosis
What is required for fusion to occur between the virus envelope and the cell membrane?
What is required for fusion to occur between the virus envelope and the cell membrane?
- Specific fusion proteins in the virus envelope (correct)
- Spike protein priming
- ACE2 receptor binding
- Host cell proteases
What occurs simultaneously in some viruses, such as bacteriophages?
What occurs simultaneously in some viruses, such as bacteriophages?
What is the result of the uncoating step in the viral life cycle?
What is the result of the uncoating step in the viral life cycle?
What is involved in the interactions between the virus and the host cell during virus entry?
What is involved in the interactions between the virus and the host cell during virus entry?
What determines the tropism of a virus?
What determines the tropism of a virus?
What is the role of viral attachment proteins?
What is the role of viral attachment proteins?
What is the usual requirement for cell entry into the host cell?
What is the usual requirement for cell entry into the host cell?
What is the primary function of host cell proteases such as TMPRSS2 and cathepsin in the priming of the spike protein?
What is the primary function of host cell proteases such as TMPRSS2 and cathepsin in the priming of the spike protein?
What is the process by which the virus is engulfed into the cell within a vesicle called an endosome?
What is the process by which the virus is engulfed into the cell within a vesicle called an endosome?
What is the result of the attachment phase of viral replication?
What is the result of the attachment phase of viral replication?
What is the rare mechanism of virus entry into host cells where the entire virus particle is transported across the cell membrane?
What is the rare mechanism of virus entry into host cells where the entire virus particle is transported across the cell membrane?
What is the name of the protease that cleaves the spike protein at a specific site located at the junction of the S1 and S2 subunits?
What is the name of the protease that cleaves the spike protein at a specific site located at the junction of the S1 and S2 subunits?
What is the result of the cleavage of the spike protein by host cell proteases?
What is the result of the cleavage of the spike protein by host cell proteases?
What is the type of RNA contained in the viral particle of SARS-CoV-2?
What is the type of RNA contained in the viral particle of SARS-CoV-2?
What is the primary function of the furin cleavage site in the spike protein of SARS-CoV-2?
What is the primary function of the furin cleavage site in the spike protein of SARS-CoV-2?
Where does the cleavage of the spike protein by TMPRSS2 and cathepsins occur?
Where does the cleavage of the spike protein by TMPRSS2 and cathepsins occur?
