Virus Entry and Receptors

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What is the role of the viral envelope?

To facilitate penetration of the host cell membrane

Which proteins are involved in the initial contact with receptors on host cells?

Viral envelope proteins

What is the function of matrix proteins in enveloped viruses?

To serve as a bridge between the nucleocapsid and the inside of the viral membrane or envelope

Which type of viruses have a defined external capsid and are referred to as naked capsid viruses?

<p>DNA viruses</p> Signup and view all the answers

What is the main role of non-structural proteins in viruses?

<p>Replication</p> Signup and view all the answers

In which part of the viral life cycle do structural proteins play a key role?

<p>Assembly of progeny virions</p> Signup and view all the answers

Which type of symmetry do most viruses have in their capsid structure?

<p>Cubic symmetry</p> Signup and view all the answers

What is the role of spikes in enveloped viruses?

<p>Initial contact with receptor on host cells</p> Signup and view all the answers

What is the role of T-cell activation in the viral life cycle?

<p>To activate the human immune system</p> Signup and view all the answers

Which of the following is a component of a typical virus?

<p>Lipid bilayer</p> Signup and view all the answers

What is the function of viral receptors and VAP found on a virus?

<p>To bind to host cell receptors</p> Signup and view all the answers

What is the classification of the Ebola virus in terms of its genetic material?

<p>RNA virus, Filoviridae family</p> Signup and view all the answers

Which of the following is a type of viral symmetry?

<p>Radial symmetry</p> Signup and view all the answers

What technique is commonly used to identify viruses in the lab?

<p>Polymerase chain reaction (PCR)</p> Signup and view all the answers

What does serology refer to in the context of virology?

<p>Study of host immune response to viruses</p> Signup and view all the answers

Which cellular process plays a role in phagocytosis of the human immune system during the viral life cycle?

<p>Endocytosis</p> Signup and view all the answers

Which protein on the surface of herpes simplex virus (HSV) mediates the initial attachment of virus particles to heparan sulfate moieties on host cell-surface proteoglycans?

<p>gB</p> Signup and view all the answers

Which receptor does gD bind to trigger membrane fusion for herpes simplex virus (HSV) entry?

<p>Nectin-1</p> Signup and view all the answers

Which of the following is the receptor for parvovirus B19 entry into erythroid precursor cells?

<p>P antigen (globoside)</p> Signup and view all the answers

Which cell type expresses high levels of P antigen receptor but lacks α5β1 integrin coreceptor, thus allowing parvovirus B19 binding but not viral entry?

<p>Mature human red blood cells (RBCs)</p> Signup and view all the answers

Which type of viruses enter cells by direct fusion mechanism, where the viral envelope fuses with the plasma membrane of the host cells?

<p>Orthomyxoviruses</p> Signup and view all the answers

Which viral protein is involved in the entry of influenza virus by binding to sialic acid receptors on respiratory epithelial cells?

<p>HA</p> Signup and view all the answers

Which protein mediates the attachment and entry of rabies virus into neurons and muscle cells?

<p>G protein</p> Signup and view all the answers

Which type of cell does rhinovirus specifically target for entry?

<p>Epithelial cells</p> Signup and view all the answers

What is the first line of defense against viral infections?

<p>Interferons</p> Signup and view all the answers

What type of cells destroy virus-infected cells?

<p>Cytotoxic T lymphocytes</p> Signup and view all the answers

What is the first specific immune response after viral infection?

<p>T-cell mediated response</p> Signup and view all the answers

What is the method used to quantitate viruses by counting plaque-forming units?

<p>Plaque assay</p> Signup and view all the answers

Which laboratory technique involves the use of cell culture to grow viruses in-vitro?

<p>Viral culture</p> Signup and view all the answers

What is the target molecule for the polymerase chain reaction (PCR)?

<p>DNA</p> Signup and view all the answers

What is the primary culture referred to in the growth of human viruses?

<p>The initial cell population before propagation</p> Signup and view all the answers

Which type of viruses are all DNA viruses, except Parvoviridae?

<p>Double-stranded genomes</p> Signup and view all the answers

What is the main feature of negative sense viruses?

<p>Single-stranded genomes</p> Signup and view all the answers

In viral pathogenesis, what aspect involves the complex interactions between viruses and hosts?

<p>Immune response</p> Signup and view all the answers

What is the main feature of innate defenses against damaging organisms and toxins?

<p>Ability to resist damaging organisms and toxins</p> Signup and view all the answers

Which factor plays an important role in determining the outcome of viral infection?

<p>Specific immune responses</p> Signup and view all the answers

What is the capability of viruses to infect a discrete population of cells within an organ called?

<p>Tropism</p> Signup and view all the answers

What does viral virulence refer to?

<p>Degree of pathogenicity of a virus</p> Signup and view all the answers

Which type of host defense includes interferons, natural killer cells, and fever?

<p>Innate immune response</p> Signup and view all the answers

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