Virus Entry and Receptors
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Questions and Answers

What is the role of the viral envelope?

  • To facilitate penetration of the host cell membrane (correct)
  • To form the capsid and package the viral genome
  • To contain the virus's genetic material
  • To encode all the information necessary to produce new progeny virions
  • Which proteins are involved in the initial contact with receptors on host cells?

  • Matrix proteins
  • Structural proteins
  • Non-structural proteins
  • Viral envelope proteins (correct)
  • What is the function of matrix proteins in enveloped viruses?

  • To serve as a bridge between the nucleocapsid and the inside of the viral membrane or envelope (correct)
  • To facilitate replication
  • To form the capsid
  • To package the viral genome
  • Which type of viruses have a defined external capsid and are referred to as naked capsid viruses?

    <p>DNA viruses</p> Signup and view all the answers

    What is the main role of non-structural proteins in viruses?

    <p>Replication</p> Signup and view all the answers

    In which part of the viral life cycle do structural proteins play a key role?

    <p>Assembly of progeny virions</p> Signup and view all the answers

    Which type of symmetry do most viruses have in their capsid structure?

    <p>Cubic symmetry</p> Signup and view all the answers

    What is the role of spikes in enveloped viruses?

    <p>Initial contact with receptor on host cells</p> Signup and view all the answers

    What is the role of T-cell activation in the viral life cycle?

    <p>To activate the human immune system</p> Signup and view all the answers

    Which of the following is a component of a typical virus?

    <p>Lipid bilayer</p> Signup and view all the answers

    What is the function of viral receptors and VAP found on a virus?

    <p>To bind to host cell receptors</p> Signup and view all the answers

    What is the classification of the Ebola virus in terms of its genetic material?

    <p>RNA virus, Filoviridae family</p> Signup and view all the answers

    Which of the following is a type of viral symmetry?

    <p>Radial symmetry</p> Signup and view all the answers

    What technique is commonly used to identify viruses in the lab?

    <p>Polymerase chain reaction (PCR)</p> Signup and view all the answers

    What does serology refer to in the context of virology?

    <p>Study of host immune response to viruses</p> Signup and view all the answers

    Which cellular process plays a role in phagocytosis of the human immune system during the viral life cycle?

    <p>Endocytosis</p> Signup and view all the answers

    Which protein on the surface of herpes simplex virus (HSV) mediates the initial attachment of virus particles to heparan sulfate moieties on host cell-surface proteoglycans?

    <p>gB</p> Signup and view all the answers

    Which receptor does gD bind to trigger membrane fusion for herpes simplex virus (HSV) entry?

    <p>Nectin-1</p> Signup and view all the answers

    Which of the following is the receptor for parvovirus B19 entry into erythroid precursor cells?

    <p>P antigen (globoside)</p> Signup and view all the answers

    Which cell type expresses high levels of P antigen receptor but lacks α5β1 integrin coreceptor, thus allowing parvovirus B19 binding but not viral entry?

    <p>Mature human red blood cells (RBCs)</p> Signup and view all the answers

    Which type of viruses enter cells by direct fusion mechanism, where the viral envelope fuses with the plasma membrane of the host cells?

    <p>Orthomyxoviruses</p> Signup and view all the answers

    Which viral protein is involved in the entry of influenza virus by binding to sialic acid receptors on respiratory epithelial cells?

    <p>HA</p> Signup and view all the answers

    Which protein mediates the attachment and entry of rabies virus into neurons and muscle cells?

    <p>G protein</p> Signup and view all the answers

    Which type of cell does rhinovirus specifically target for entry?

    <p>Epithelial cells</p> Signup and view all the answers

    What is the first line of defense against viral infections?

    <p>Interferons</p> Signup and view all the answers

    What type of cells destroy virus-infected cells?

    <p>Cytotoxic T lymphocytes</p> Signup and view all the answers

    What is the first specific immune response after viral infection?

    <p>T-cell mediated response</p> Signup and view all the answers

    What is the method used to quantitate viruses by counting plaque-forming units?

    <p>Plaque assay</p> Signup and view all the answers

    Which laboratory technique involves the use of cell culture to grow viruses in-vitro?

    <p>Viral culture</p> Signup and view all the answers

    What is the target molecule for the polymerase chain reaction (PCR)?

    <p>DNA</p> Signup and view all the answers

    What is the primary culture referred to in the growth of human viruses?

    <p>The initial cell population before propagation</p> Signup and view all the answers

    Which type of viruses are all DNA viruses, except Parvoviridae?

    <p>Double-stranded genomes</p> Signup and view all the answers

    What is the main feature of negative sense viruses?

    <p>Single-stranded genomes</p> Signup and view all the answers

    In viral pathogenesis, what aspect involves the complex interactions between viruses and hosts?

    <p>Immune response</p> Signup and view all the answers

    What is the main feature of innate defenses against damaging organisms and toxins?

    <p>Ability to resist damaging organisms and toxins</p> Signup and view all the answers

    Which factor plays an important role in determining the outcome of viral infection?

    <p>Specific immune responses</p> Signup and view all the answers

    What is the capability of viruses to infect a discrete population of cells within an organ called?

    <p>Tropism</p> Signup and view all the answers

    What does viral virulence refer to?

    <p>Degree of pathogenicity of a virus</p> Signup and view all the answers

    Which type of host defense includes interferons, natural killer cells, and fever?

    <p>Innate immune response</p> Signup and view all the answers

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