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Questions and Answers
Which of the listed characteristics is NOT a primary criterion used in the traditional hierarchical virus classification system?
Which of the listed characteristics is NOT a primary criterion used in the traditional hierarchical virus classification system?
- Symmetry of the capsid.
- Nature of the nucleic acid (DNA or RNA).
- Specific host cell receptor interaction. (correct)
- Presence or absence of an envelope.
In the Baltimore classification system, what serves as the central point for categorizing viruses?
In the Baltimore classification system, what serves as the central point for categorizing viruses?
- Type of capsid symmetry.
- Size of the viral genome.
- Production of mRNA (+ sense RNA). (correct)
- Presence of a viral envelope.
How does the genomic system classify viruses, especially in recent years?
How does the genomic system classify viruses, especially in recent years?
- According to the geographical location where the virus was first isolated.
- Based on the host organism infected.
- Primarily by the size and shape of the virion.
- By analyzing the DNA or RNA sequence. (correct)
A newly discovered virus has been found to contain a single-stranded RNA genome and lacks an envelope. According to the traditional hierarchical classification, to what level can this virus be classified with the information provided?
A newly discovered virus has been found to contain a single-stranded RNA genome and lacks an envelope. According to the traditional hierarchical classification, to what level can this virus be classified with the information provided?
If a virus is classified as a positive-sense RNA virus by the Baltimore classification system, what key process must it perform upon entering a host cell?
If a virus is classified as a positive-sense RNA virus by the Baltimore classification system, what key process must it perform upon entering a host cell?
Which of the following characteristics is NOT a primary factor in determining the shape of a virus?
Which of the following characteristics is NOT a primary factor in determining the shape of a virus?
If a newly discovered virus has a capsid that appears to have flat sides and edges when viewed under an electron microscope, which shape would be most likely?
If a newly discovered virus has a capsid that appears to have flat sides and edges when viewed under an electron microscope, which shape would be most likely?
A researcher identifies a virus that infects bacteria and has a distinct head-tail structure. The head appears icosahedral, and the tail is helical. How should this virus be classified based on its shape?
A researcher identifies a virus that infects bacteria and has a distinct head-tail structure. The head appears icosahedral, and the tail is helical. How should this virus be classified based on its shape?
Which of the following viruses is known to have the largest diameter?
Which of the following viruses is known to have the largest diameter?
A newly discovered virus infects only specific strains of a bacterial species. This is an example of:
A newly discovered virus infects only specific strains of a bacterial species. This is an example of:
Which of the following factors is MOST crucial for a virus to successfully infect a host cell?
Which of the following factors is MOST crucial for a virus to successfully infect a host cell?
What is the function of the protein subunits that surround the RNA molecules in a non-enveloped helical virus such as the Tobacco Mosaic Virus (TMV)?
What is the function of the protein subunits that surround the RNA molecules in a non-enveloped helical virus such as the Tobacco Mosaic Virus (TMV)?
A virus is found to exclusively target and infect nerve cells in humans. What property of this virus allows it to exhibit such specific targeting?
A virus is found to exclusively target and infect nerve cells in humans. What property of this virus allows it to exhibit such specific targeting?
Which factor primarily dictates a virus's capacity to infect a specific host cell?
Which factor primarily dictates a virus's capacity to infect a specific host cell?
A virus with a narrow host range is MOST likely to infect:
A virus with a narrow host range is MOST likely to infect:
Before 1966, how were viruses commonly named?
Before 1966, how were viruses commonly named?
The ICTV's (International Committee on Taxonomy of Viruses) classification system is MOST important from which taxonomic level?
The ICTV's (International Committee on Taxonomy of Viruses) classification system is MOST important from which taxonomic level?
What MUST occur before any translation can occur for a virus with a negative-sense (-) RNA genome?
What MUST occur before any translation can occur for a virus with a negative-sense (-) RNA genome?
Which characteristic is NOT a primary factor used in the classification of viruses?
Which characteristic is NOT a primary factor used in the classification of viruses?
Which of the following viruses is MOST likely to exhibit a broad host range?
Which of the following viruses is MOST likely to exhibit a broad host range?
What is the correct suffix for viral families in the hierarchical virus classification?
What is the correct suffix for viral families in the hierarchical virus classification?
Which characteristic of viral capsomeres is most important for viral classification and identification?
Which characteristic of viral capsomeres is most important for viral classification and identification?
What is the primary difference between a naked virus and an enveloped virus?
What is the primary difference between a naked virus and an enveloped virus?
Which component of an enveloped virus is typically derived from the host cell during the budding process?
Which component of an enveloped virus is typically derived from the host cell during the budding process?
What is the term for a complete virus particle, including its envelope (if present)?
What is the term for a complete virus particle, including its envelope (if present)?
What advantage do envelope proteins provide to viruses regarding the host's immune system?
What advantage do envelope proteins provide to viruses regarding the host's immune system?
Which environmental condition is least likely to damage enveloped viruses?
Which environmental condition is least likely to damage enveloped viruses?
Viruses are considered metabolically inert outside of a host cell. What does this imply about their ability to function?
Viruses are considered metabolically inert outside of a host cell. What does this imply about their ability to function?
What is the function of the glycoprotein spikes found on the surface of some viruses?
What is the function of the glycoprotein spikes found on the surface of some viruses?
Why is the property of hemagglutination useful in viral identification?
Why is the property of hemagglutination useful in viral identification?
A newly discovered microorganism is non-cellular and contains DNA enclosed within a protein coat. It can only replicate inside a host cell. Which of the following is the most likely classification of this microorganism?
A newly discovered microorganism is non-cellular and contains DNA enclosed within a protein coat. It can only replicate inside a host cell. Which of the following is the most likely classification of this microorganism?
Which of the characteristics listed is NOT a feature of viruses?
Which of the characteristics listed is NOT a feature of viruses?
Outside of a host cell, a virus is metabolically inactive. How does the virus become active?
Outside of a host cell, a virus is metabolically inactive. How does the virus become active?
A researcher is studying a virus and finds that its genetic material is single-stranded RNA. Which of the following accurately describes the genetic composition of this virus?
A researcher is studying a virus and finds that its genetic material is single-stranded RNA. Which of the following accurately describes the genetic composition of this virus?
What is the primary function of the capsid?
What is the primary function of the capsid?
Which of the following components are found in ALL viruses?
Which of the following components are found in ALL viruses?
Why are viruses not classified into any of the established biological kingdoms (e.g., Animalia, Plantae, Fungi)?
Why are viruses not classified into any of the established biological kingdoms (e.g., Animalia, Plantae, Fungi)?
Flashcards
Definition of Virus
Definition of Virus
An infectious agent that can multiply only in living cells.
Characteristics of Viruses
Characteristics of Viruses
Viruses are small, non-cellular, obligate intracellular parasites.
Virus Components
Virus Components
Viruses contain nucleic acid, capsid, and sometimes an envelope protein.
Nucleic Acid in Viruses
Nucleic Acid in Viruses
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Capsid Function
Capsid Function
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Obligate Intracellular Parasite
Obligate Intracellular Parasite
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Metabolic Activity of Viruses
Metabolic Activity of Viruses
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Virus Replication Process
Virus Replication Process
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Capsomeres
Capsomeres
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Naked Virus
Naked Virus
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Enveloped Virus
Enveloped Virus
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Virion
Virion
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Nucleocapsid
Nucleocapsid
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Spikes
Spikes
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Hemagglutination
Hemagglutination
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Viral Size
Viral Size
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Smallest Virus
Smallest Virus
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Hierarchical Classification
Hierarchical Classification
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Largest Virus
Largest Virus
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Baltimore Classification System
Baltimore Classification System
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Helical Virus Shape
Helical Virus Shape
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Viral Characteristics
Viral Characteristics
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Polyhedral Virus Shape
Polyhedral Virus Shape
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Genomic Classification
Genomic Classification
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Complex Virus Structure
Complex Virus Structure
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mRNA Sense
mRNA Sense
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Animal Viruses
Animal Viruses
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Plant Viruses
Plant Viruses
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Host Range Specificity
Host Range Specificity
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Broad host range
Broad host range
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Narrow host range
Narrow host range
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Virus specificity
Virus specificity
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Classification of viruses
Classification of viruses
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Nucleic acid types
Nucleic acid types
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Virus coat morphology
Virus coat morphology
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Hierarchical virus classification
Hierarchical virus classification
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Virus nomenclature history
Virus nomenclature history
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Study Notes
Virus Introduction
- Viruses are infectious agents.
- They are very small, requiring a microscope to see.
- They are not part of any kingdom (not plants, animals, fungi, protists, or bacteria).
- They are obligate intracellular parasites; they can only replicate within a host cell, relying on host metabolic processes.
- Viral diseases result from the interaction between the virus and host cell.
Virus Characteristics
- Viruses are too small to be seen with a light microscope.
- They are non-cellular, lacking a nucleus, organelles, cytoplasm, or cell membrane.
- Viruses are obligate intracellular parasites, meaning they multiply only inside living cells.
- They cannot divide or live outside a host cell.
- Outside a host cell (extracellular), viral metabolism is inactive, and biosynthetic functions are impossible.
- Once inside a cell, they direct host machinery to produce new complete viral particles (virions), which complete the replication process.
Virus Components
- Viruses contain nucleic acid (either DNA or RNA).
- The capsid, composed of capsomeres, provides a protective protein coat.
- Some viruses have an envelope, a lipid-protein membrane outside the capsid.
- The envelope is derived from host cell membranes, and the material may include carbohydrates
- The nucleocapsid contains the viral genome along with the capsid.
Viral Nucleic Acid
- Viruses contain either DNA or RNA, but not both.
- Nucleic acid can be double-stranded (DS), single-stranded (SS), linear, circular, or segmented.
Viral Capsids
- The capsid (or capsids) is the surrounding protein coat around the nucleic acid.
- Determine the shape of the virus.
- Contains protein subunits known as capsomeres.
- The number and arrangement of capsomeres are important in classifying and identifying viruses.
Viral Envelopes
- Some viruses have a membrane called an envelope surrounding the capsid.
- Consisting of lipids, proteins, and carbohydrates
- Enveloped viruses are often derived from host cell membranes as they bud from or detach from the host cell.
- Enveloped viruses can lose their envelope under harsh conditions (e.g., high temperature, freezing/thawing, certain chemicals).
Viral Shapes and Sizes
- Viruses exhibit various shapes (helical, polyhedral, complex).
- Sizes fluctuate among different viruses.
- Measured in nanometers (nm).
- Poliovirus (28 nm) is the smallest virus shown; smallpox viruses are large (200 nm).
Host Range and Specificity
- Viruses have a limited host range, attacking only one or a few host types or cell types.
- Viruses show specificity for cells/tissue—a complementary fit between external viral proteins and host cell surface proteins.
- This specificity impacts the host cells infected.
- Broad-range viruses can infect various host types (e.g., swine flu and rabies), while narrow-range viruses are limited to a single tissue type in a single species (e.g., HIV, phages on E. coli).
Virus Classification
- Viruses are classified based on their genetic material, morphology of their capsid, presence or absence of an envelope, and their host range.
- The ICTV (International Committee on Taxonomy of Viruses) maintains a systematic system for classifying viruses.
- Historically, method classification has been developed using the following:
- type of disease caused;
- site of the first virus isolation;
- scientific discoverer of the virus;
- perceived method of contraction
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