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What is the most common type of calicivirus?
What is the most common type of calicivirus?
Where does the replication of calicivirus occur?
Where does the replication of calicivirus occur?
What is a common route of transmission for calicivirus?
What is a common route of transmission for calicivirus?
What is a characteristic of the protein produced by calicivirus?
What is a characteristic of the protein produced by calicivirus?
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What is the typical duration of illness caused by Norwalk virus?
What is the typical duration of illness caused by Norwalk virus?
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What is a common setting where outbreaks of calicivirus often occur?
What is a common setting where outbreaks of calicivirus often occur?
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Study Notes
Calicivirus
- Positively stranded RNA virus
Structure and Replication
- Produces one long single protein that is cleaved by viral proteases into smaller active constituents
- Replicates in the cytoplasm like all positive-stranded RNA viruses
Types of Calicivirus
- Norovirus (Norwalk virus) is the most common type
Epidemiology
- Commonly affects people in closed quarters (e.g. cruise ships, daycare centers)
- 90% of all diarrhea outbreaks on cruises are caused by norovirus
- Can be transmitted through consumption of contaminated shellfish or food handled by infected individuals
Clinical Features
- Symptoms: nausea, vomiting, diarrhea
- Damages intestinal brush border
- Short incubation period (1-2 days)
- Illness resolves within 60 hours without complications
Viral Characteristics
- Resistant to chlorine and desiccation
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