lecture 25- immunology

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Questions and Answers

What is the primary goal of viruses targeting and infecting immune cells?

  • Induce inflammatory responses
  • Enhance host immunity
  • Facilitate viral replication (correct)
  • Promote host cell growth

How do viruses evade host immunity by depleting CD4+ T cells?

  • Compromising the host's adaptive immune system (correct)
  • Stimulating antibody production
  • Enhancing adaptive immune responses
  • Promoting host cell differentiation

Which of the following is a mechanism viruses use to evade host immunity mentioned in the text?

  • Promote immune cell growth
  • Suppress inflammatory responses (correct)
  • Enhance immune signaling pathways
  • Induce CTL activation

What property makes vaccination most effective against microbes?

<p>Undergoing antigenic variation (B)</p> Signup and view all the answers

Why is understanding viral evasion mechanisms crucial for developing antiviral therapies and vaccines?

<p>To counteract viral immune evasion strategies (C)</p> Signup and view all the answers

What is the key mechanism highlighted in the text that viruses use to evade host immunity?

<p>Surface antigen alterations (C)</p> Signup and view all the answers

What is the role of the transporter associated with antigen processing (TAP) protein in the Class I MHC pathway?

<p>Transports peptides from ER to cytosol (B)</p> Signup and view all the answers

Why do alterations in surface antigens help viruses evade host immunity?

<p>To avoid immune detection and elimination (A)</p> Signup and view all the answers

Which viral evasion strategy involves inhibiting steps in the Class I MHC pathway?

<p>Inhibition of antigen processing (D)</p> Signup and view all the answers

How does inhibiting antigen processing and Class I MHC presentation impact infected cells?

<p>Decreases immune response effectiveness (B)</p> Signup and view all the answers

How do some viruses evade immune detection and clearance?

<p>By inhibiting key steps in the immune response (A)</p> Signup and view all the answers

What is a potential consequence of animals serving as reservoirs for viruses?

<p>Continuous transmission of the virus (A)</p> Signup and view all the answers

Which factor is crucial for developing effective vaccination strategies against viruses?

<p>Understanding properties of the target microbe (A)</p> Signup and view all the answers

The shift in focus to immunity against bacteria, fungi, and parasites is mentioned as a result of what?

<p>Understanding the importance of other microbial threats (C)</p> Signup and view all the answers

Why is it essential to address factors like latency and antigenic variation in vaccination strategies?

<p>To improve vaccine efficacy and immune protection (A)</p> Signup and view all the answers

What term describes the gradual changes in surface antigens of viruses due to point mutations?

<p>Antigenic drift (C)</p> Signup and view all the answers

Which mechanism involves sudden and significant changes in surface antigens of viruses due to genetic reassortment between different viral strains?

<p>Antigenic shift (D)</p> Signup and view all the answers

What is the significance of viral evasion of host immunity through alterations in surface antigens?

<p>Challenging immune responses (B)</p> Signup and view all the answers

Why does viral alteration of surface antigens create strains that are no longer recognized by the immune system?

<p>Caused by genetic changes (A)</p> Signup and view all the answers

How do alterations in surface antigens contribute to the spread of viruses within populations?

<p>Via reduced recognition by the immune system (A)</p> Signup and view all the answers

What type of immune response provides early defense against microbes?

<p>Innate immunity (D)</p> Signup and view all the answers

How do many pathogenic microbes ensure their survival?

<p>By resisting innate immunity (A)</p> Signup and view all the answers

What is a key factor that influences the success of vaccination?

<p>The properties of the target microbe (B)</p> Signup and view all the answers

Which statement best describes the relationship between infectious microbes and the immune system?

<p>They are in constant conflict for survival (B)</p> Signup and view all the answers

How do some microbes establish latent or persistent infections?

<p>By being controlled but not eliminated by the immune response (C)</p> Signup and view all the answers

How does understanding the mechanisms of immune evasion and resistance help combat infectious diseases?

<p>By developing targeted approaches to combat pathogens (B)</p> Signup and view all the answers

What role do defects in immunity play in susceptibility to infections?

<p>They increase vulnerability to certain types of infections (C)</p> Signup and view all the answers

Why is studying immune responses important in managing infections?

<p>To assess the severity and guide treatment strategies (A)</p> Signup and view all the answers

In what way do microbes with effective evasion mechanisms impact infection severity?

<p>They are more likely to cause severe infections (D)</p> Signup and view all the answers

What is crucial for developing effective strategies to prevent, treat, and manage infectious diseases?

<p>Understanding the interplay between the immune system and microbes (A)</p> Signup and view all the answers

What is the role of viral decoy molecules in protecting infected cells from NK cell-mediated killing?

<p>Competing with pro-inflammatory cytokines (C)</p> Signup and view all the answers

How do viral proteins interact with natural killer (NK) cell receptors to evade immune surveillance?

<p>By acting as ligands for NK cell inhibitory receptors (A)</p> Signup and view all the answers

Why do viruses encode proteins that act as ligands for inhibitory receptors on natural killer (NK) cells?

<p>To evade immune surveillance and inhibit NK cell-mediated killing (A)</p> Signup and view all the answers

What is the purpose of viruses inhibiting antigen processing and Class I MHC presentation?

<p>To evade recognition by cytotoxic T lymphocytes (D)</p> Signup and view all the answers

Which mechanism do viruses use to compete with cytokines and protect infected cells from natural killer cell-mediated killing?

<p>Functioning as decoy signal molecules (D)</p> Signup and view all the answers

How do viruses evade the host immune system by resembling MHC class I proteins?

<p>By interacting with natural killer cell receptors (A)</p> Signup and view all the answers

In what way do viral proteins mimic the action of immunosuppressive cytokines like IL-10?

<p>By binding and inhibiting pro-inflammatory cytokines (C)</p> Signup and view all the answers

What role do viral proteins that act as ligands for NK cell inhibitory receptors play in evasion of immune surveillance?

<p>Preventing NK cell-mediated killing of infected cells (D)</p> Signup and view all the answers

How do viruses manage to evade recognition by cytotoxic T lymphocytes?

<p>Through inhibition of antigen processing pathways (C)</p> Signup and view all the answers

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