lecture 25- immunology
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Questions and Answers

What is the primary goal of viruses targeting and infecting immune cells?

  • Induce inflammatory responses
  • Enhance host immunity
  • Facilitate viral replication (correct)
  • Promote host cell growth
  • How do viruses evade host immunity by depleting CD4+ T cells?

  • Compromising the host's adaptive immune system (correct)
  • Stimulating antibody production
  • Enhancing adaptive immune responses
  • Promoting host cell differentiation
  • Which of the following is a mechanism viruses use to evade host immunity mentioned in the text?

  • Promote immune cell growth
  • Suppress inflammatory responses (correct)
  • Enhance immune signaling pathways
  • Induce CTL activation
  • What property makes vaccination most effective against microbes?

    <p>Undergoing antigenic variation</p> Signup and view all the answers

    Why is understanding viral evasion mechanisms crucial for developing antiviral therapies and vaccines?

    <p>To counteract viral immune evasion strategies</p> Signup and view all the answers

    What is the key mechanism highlighted in the text that viruses use to evade host immunity?

    <p>Surface antigen alterations</p> Signup and view all the answers

    What is the role of the transporter associated with antigen processing (TAP) protein in the Class I MHC pathway?

    <p>Transports peptides from ER to cytosol</p> Signup and view all the answers

    Why do alterations in surface antigens help viruses evade host immunity?

    <p>To avoid immune detection and elimination</p> Signup and view all the answers

    Which viral evasion strategy involves inhibiting steps in the Class I MHC pathway?

    <p>Inhibition of antigen processing</p> Signup and view all the answers

    How does inhibiting antigen processing and Class I MHC presentation impact infected cells?

    <p>Decreases immune response effectiveness</p> Signup and view all the answers

    How do some viruses evade immune detection and clearance?

    <p>By inhibiting key steps in the immune response</p> Signup and view all the answers

    What is a potential consequence of animals serving as reservoirs for viruses?

    <p>Continuous transmission of the virus</p> Signup and view all the answers

    Which factor is crucial for developing effective vaccination strategies against viruses?

    <p>Understanding properties of the target microbe</p> Signup and view all the answers

    The shift in focus to immunity against bacteria, fungi, and parasites is mentioned as a result of what?

    <p>Understanding the importance of other microbial threats</p> Signup and view all the answers

    Why is it essential to address factors like latency and antigenic variation in vaccination strategies?

    <p>To improve vaccine efficacy and immune protection</p> Signup and view all the answers

    What term describes the gradual changes in surface antigens of viruses due to point mutations?

    <p>Antigenic drift</p> Signup and view all the answers

    Which mechanism involves sudden and significant changes in surface antigens of viruses due to genetic reassortment between different viral strains?

    <p>Antigenic shift</p> Signup and view all the answers

    What is the significance of viral evasion of host immunity through alterations in surface antigens?

    <p>Challenging immune responses</p> Signup and view all the answers

    Why does viral alteration of surface antigens create strains that are no longer recognized by the immune system?

    <p>Caused by genetic changes</p> Signup and view all the answers

    How do alterations in surface antigens contribute to the spread of viruses within populations?

    <p>Via reduced recognition by the immune system</p> Signup and view all the answers

    What type of immune response provides early defense against microbes?

    <p>Innate immunity</p> Signup and view all the answers

    How do many pathogenic microbes ensure their survival?

    <p>By resisting innate immunity</p> Signup and view all the answers

    What is a key factor that influences the success of vaccination?

    <p>The properties of the target microbe</p> Signup and view all the answers

    Which statement best describes the relationship between infectious microbes and the immune system?

    <p>They are in constant conflict for survival</p> Signup and view all the answers

    How do some microbes establish latent or persistent infections?

    <p>By being controlled but not eliminated by the immune response</p> Signup and view all the answers

    How does understanding the mechanisms of immune evasion and resistance help combat infectious diseases?

    <p>By developing targeted approaches to combat pathogens</p> Signup and view all the answers

    What role do defects in immunity play in susceptibility to infections?

    <p>They increase vulnerability to certain types of infections</p> Signup and view all the answers

    Why is studying immune responses important in managing infections?

    <p>To assess the severity and guide treatment strategies</p> Signup and view all the answers

    In what way do microbes with effective evasion mechanisms impact infection severity?

    <p>They are more likely to cause severe infections</p> Signup and view all the answers

    What is crucial for developing effective strategies to prevent, treat, and manage infectious diseases?

    <p>Understanding the interplay between the immune system and microbes</p> Signup and view all the answers

    What is the role of viral decoy molecules in protecting infected cells from NK cell-mediated killing?

    <p>Competing with pro-inflammatory cytokines</p> Signup and view all the answers

    How do viral proteins interact with natural killer (NK) cell receptors to evade immune surveillance?

    <p>By acting as ligands for NK cell inhibitory receptors</p> Signup and view all the answers

    Why do viruses encode proteins that act as ligands for inhibitory receptors on natural killer (NK) cells?

    <p>To evade immune surveillance and inhibit NK cell-mediated killing</p> Signup and view all the answers

    What is the purpose of viruses inhibiting antigen processing and Class I MHC presentation?

    <p>To evade recognition by cytotoxic T lymphocytes</p> Signup and view all the answers

    Which mechanism do viruses use to compete with cytokines and protect infected cells from natural killer cell-mediated killing?

    <p>Functioning as decoy signal molecules</p> Signup and view all the answers

    How do viruses evade the host immune system by resembling MHC class I proteins?

    <p>By interacting with natural killer cell receptors</p> Signup and view all the answers

    In what way do viral proteins mimic the action of immunosuppressive cytokines like IL-10?

    <p>By binding and inhibiting pro-inflammatory cytokines</p> Signup and view all the answers

    What role do viral proteins that act as ligands for NK cell inhibitory receptors play in evasion of immune surveillance?

    <p>Preventing NK cell-mediated killing of infected cells</p> Signup and view all the answers

    How do viruses manage to evade recognition by cytotoxic T lymphocytes?

    <p>Through inhibition of antigen processing pathways</p> Signup and view all the answers

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