Viral Infections and Hyperthermia Quiz

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Questions and Answers

What is the primary effect of ionizing radiation on rapidly proliferating cells?

  • It kills the cells (correct)
  • It increases cell mutation rates
  • It promotes cell growth
  • It enhances cell division

Which of the following is a consequence of radiation exposure during pregnancy?

  • Decreased chances of birth defects
  • Increased likelihood of abortions (correct)
  • Higher chances of normal birth outcomes
  • Improved fetal health

What percentage of women who were pregnant during the atomic bomb explosions at Hiroshima and Nagasaki gave birth to children with severe birth defects involving the central nervous system?

  • 10%
  • 75%
  • 50%
  • 25% (correct)

In addition to being teratogenic, what other significant effect does radiation have on cells?

<p>It is a mutagenic agent (A)</p> Signup and view all the answers

What is a potential outcome of genetic alteration of germ cells due to ionizing radiation?

<p>Subsequent malformations (C)</p> Signup and view all the answers

What defines a syndrome in the context of abnormalities?

<p>A group of anomalies with a specific common cause. (B)</p> Signup and view all the answers

Which of the following statements correctly describes an association?

<p>An association is when anomalies appear together more frequently than by chance alone. (D)</p> Signup and view all the answers

What is a key characteristic that differentiates a syndrome from an association?

<p>Syndromes have known causes, while associations do not determine causation. (D)</p> Signup and view all the answers

Which of the following is an example of an association?

<p>VACTERL association. (B)</p> Signup and view all the answers

Why is recognizing anomalies in an association important?

<p>It promotes the search for other abnormalities within the group. (A)</p> Signup and view all the answers

What percentage of birth defect cases have an unknown cause?

<p>40% to 60% (B)</p> Signup and view all the answers

How do environmental factors contribute to the occurrence of birth defects?

<p>They account for about 10% of cases. (C)</p> Signup and view all the answers

What is the relationship between the number of minor anomalies and the chance of having major malformations in infants?

<p>Three or more minor anomalies result in a 20% chance. (C)</p> Signup and view all the answers

What is the primary cause of malformations during fetal development?

<p>Environmental and/or genetic factors during organ formation (D)</p> Signup and view all the answers

What percentage of newborns are affected by minor anomalies?

<p>15% (B)</p> Signup and view all the answers

In cases of twinning, what percentage contributes to birth defects?

<p>0.5% to 1% (D)</p> Signup and view all the answers

Which of the following is an example of a deformation?

<p>Clubfeet resulting from compression in the amniotic cavity (A)</p> Signup and view all the answers

Which infectious agent is associated with significant birth defects and often shows no symptoms in the mother?

<p>Cytomegalovirus (A)</p> Signup and view all the answers

What characterizes disruptions in fetal development?

<p>They involve morphological alterations of already formed structures. (A)</p> Signup and view all the answers

During which weeks of gestation do most malformations typically originate?

<p>Third to eighth week (D)</p> Signup and view all the answers

What percentage of women are currently immune to Rubella, reducing the incidence of related birth defects?

<p>85% (A)</p> Signup and view all the answers

Which of the following viruses is NOT listed as a cause of birth defects?

<p>Papillomavirus (D)</p> Signup and view all the answers

Which condition would best be classified as a disruption?

<p>A limb absence from amniotic band syndrome (A)</p> Signup and view all the answers

Which birth defect-causing virus can lead to severe mental impairment, such as mental retardation, due to its effects on the fetus?

<p>Cytomegalovirus (A)</p> Signup and view all the answers

What was a significant factor in reducing birth defects caused by Rubella?

<p>Vaccine and serum antibody detection (D)</p> Signup and view all the answers

Which viral infections have been associated with malformations following maternal infection?

<p>Measles, Mumps, and Hepatitis (B)</p> Signup and view all the answers

What is a characteristic feature of fetal infection due to Toxoplasmosis?

<p>Calcifications (A)</p> Signup and view all the answers

Which of the following sources can carry Toxoplasmosis gondii?

<p>Poorly cooked meat (C)</p> Signup and view all the answers

What is the general rate of malformations indicated by prospective studies following maternal infections with certain viral agents?

<p>Low or nonexistent malformation rate (D)</p> Signup and view all the answers

Which condition is NOT mentioned as causing birth defects?

<p>Hepatitis (D)</p> Signup and view all the answers

What is the primary field of study concerned with birth defects?

<p>Teratology and dysmorphology (A)</p> Signup and view all the answers

What percentage of liveborn infants are identified with major structural anomalies?

<p>2% to 3% (C)</p> Signup and view all the answers

What is the significance of birth defects in infant mortality?

<p>They are the leading cause of infant mortality. (C)</p> Signup and view all the answers

What role do dysmorphologists typically play in clinical settings?

<p>They work in clinical genetics departments. (A)</p> Signup and view all the answers

In addition to infant mortality, what other impact do birth defects have?

<p>They are the fifth leading cause of years of potential life lost before age 65. (A)</p> Signup and view all the answers

What makes it challenging to assess the role of chemical agents in human abnormalities?

<p>The reliance on mothers' memory for exposure history and the high number of drugs taken. (B)</p> Signup and view all the answers

Which drug is specifically mentioned as having a causal relationship with meromelia?

<p>Thalidomide (A)</p> Signup and view all the answers

Why might the association between common birth defects and drug exposure be overlooked?

<p>Defects like cleft lip or heart malformations occur frequently. (B)</p> Signup and view all the answers

What kind of studies are primarily used to assess the impact of pharmaceutical drugs on pregnant women?

<p>Retrospective studies. (D)</p> Signup and view all the answers

What is a consequence of the widespread use of chemical agents during pregnancy?

<p>Few drugs have been positively identified as teratogenic. (B)</p> Signup and view all the answers

What primarily influences susceptibility to teratogenesis in a conceptus?

<p>The genotype of the conceptus and maternal genome interactions (B)</p> Signup and view all the answers

During which period of gestation is the conceptus most sensitive to teratogenic exposure?

<p>Third to eighth weeks of gestation (C)</p> Signup and view all the answers

What is a key factor in the manifestations of abnormal development caused by teratogens?

<p>Dose and duration of exposure to the teratogen (B)</p> Signup and view all the answers

How do teratogens typically affect developing cells and tissues?

<p>They initiate abnormal embryogenesis through various mechanisms (D)</p> Signup and view all the answers

Which of the following is NOT a manifestation of abnormal development caused by teratogens?

<p>Fatigue in the mother (D)</p> Signup and view all the answers

Flashcards

Maternal viral infections

Infection during pregnancy that can cause malformations in the baby.

Toxoplasmosis

A type of parasitic infection that can affect the developing baby and cause birth defects.

Syphilis

A bacterial infection that can be passed from mother to baby and cause birth defects.

Calcifications

A characteristic sign of fetal toxoplasmosis infection.

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Toxoplasma gondii

The protozoan parasite that causes toxoplasmosis.

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Syndrome

A group of abnormalities occurring together with a known common cause, indicating a diagnosis has been made, suggesting a pattern and potential recurrence.

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Association

The non-random appearance of two or more anomalies occurring together more frequently than by chance, with an undetermined cause.

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VACTERL association

An association characterized by the occurrence of vertebral, anal, cardiac, tracheoesophageal, renal, and limb abnormalities together.

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Association vs Syndrome

In contrast to syndromes, associations do not constitute a diagnosis.

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Significance of Associations

Recognition of one or more components of an association can prompt the search for other abnormalities within the group.

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Radiation as a Teratogen

Ionizing radiation can cause severe developmental abnormalities in a fetus, leading to a wide range of birth defects.

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Radiation's Impact on Fetal Development

Radiation can harm a developing fetus at any stage, but the type of defect depends on how developed the baby is when exposed.

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Radiation's Effects on Pregnancy

Radiation exposure during pregnancy can lead to miscarriage, stillbirth, and severe birth defects in the child.

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Radiation as a Mutagenic Agent

Radiation is also known to alter genes in reproductive cells, leading to birth defects in future generations.

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Inherited Radiation-Induced Birth Defects

Changes in DNA caused by radiation can be passed down to future generations, causing birth defects even if the parents weren't exposed.

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Birth defect

Any structural, behavioral, functional, or metabolic disorder present at birth.

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Teratology

The study of birth defects.

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Dysmorphology

The study of abnormal physical features.

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Dysmorphologist

A specialist who studies birth defects, typically part of a clinical genetics department.

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Birth defects

A significant cause of infant mortality, accounting for 21% of infant deaths.

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Malformation

An abnormality that occurs during the formation of structures, such as organs, caused by genetic or environmental factors.

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Deformation

An abnormality that occurs due to mechanical forces that mold a part of the fetus over a prolonged period, often affecting the musculoskeletal system.

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Disruption

An alteration in an already formed structure caused by a destructive process, interrupting normal development.

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Bowel Atresia

A condition where the digestive tract is incomplete or blocked, typically caused by disruptions during development.

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Amniotic Bands

Fibrous bands in the amniotic sac that can wrap around a fetus, leading to constrictions and disruptions.

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Cytomegalovirus

A virus that can be passed from a pregnant woman to her developing baby, potentially causing birth defects. It is often asymptomatic in the mother but can have serious consequences for the fetus, including death or mental retardation.

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Herpes simplex virus

A virus that can cause birth defects, including mental retardation, if a pregnant woman is infected. This virus is often fatal for the fetus.

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Varicella virus

A virus that can cause birth defects, including mental retardation, if a pregnant woman is infected. The virus is often asymptomatic in the mother but can have serious consequences for the fetus.

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Human Immunodeficiency Virus (HIV)

A virus that can cause birth defects, including developmental problems and weakened immune systems, if a pregnant woman is infected. The virus can be passed from the mother to the child during pregnancy or childbirth.

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Rubella

A virus that can cause birth defects, including deafness, blindness, and heart defects, if a pregnant woman is infected. The virus can be passed from the mother to the child during pregnancy or childbirth.

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Susceptibility to teratogenesis

The likelihood of an agent causing birth defects depends on the genetic makeup of the developing fetus.

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Susceptibility to teratogens

The time of exposure to a teratogen during pregnancy significantly affects the outcome. The period of organ development is the most vulnerable.

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Manifestations of abnormal development

The amount of exposure to a teratogen and how long the exposure lasts determine the severity of the birth defects.

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Teratogens act in specific ways

Teratogens disrupt normal development at the cellular level by interfering with specific processes or causing cell death.

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Manifestations of abnormal development

The outcomes of teratogenic exposure range from death of the fetus to physical deformities, slowed growth, and functional impairments.

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Teratogenic Drugs

Drugs taken by mothers during pregnancy that can lead to birth defects in the baby.

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Thalidomide

A drug formerly used to treat nausea and sleep problems during pregnancy, now known to cause severe birth defects.

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Amelia and Meromelia

Absence of some or all of the limbs in a baby.

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Identifying Birth Defect Causes

Identifying the cause of a birth defect can be difficult, especially if the defect is common.

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Minor Anomalies

Minor anomalies that are not harmful alone, but can indicate a higher risk of major defects.

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Frequency of Minor Anomalies

Minor anomalies, like small ears or pigmented spots, can occur in 15% of babies. These are not harmful themselves, but can signal the presence of more serious defects.

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Minor Anomalies and Major Defects

The presence of several minor anomalies suggests a higher chance of major defects. One minor anomaly gives a 3% chance, two a 10% chance, and three or more an even greater 20% chance.

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Study Notes

Other Viral Infections and Hyperthermia

  • Malformations from maternal infections with measles, mumps, hepatitis, poliomyelitis, echovirus, coxsackie virus, and influenza virus have been described.
  • Prospective studies show the rate of malformation after exposure to these agents is low.
  • Toxoplasmosis and syphilis cause birth defects.
  • Poorly cooked meat from domestic animals, especially cats, and feces in contaminated soil can carry the protozoan parasite Toxoplasma gondii.
  • A characteristic feature of fetal toxoplasmosis infection is calcification.

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