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Viral Genetic Mutations: Antigenic Drift and Shift

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12 Questions

What is the term used to describe minor changes in a virus due to mutations in its DNA or RNA?

Point mutations

When two genetically distinct viruses infect a cell, what process results in a major change in the virus's genome?

Antigenic shift

What type of genetic interaction among viruses results in progeny with traits not found in either parent?

Recombination

Which mechanism involves the exchange of genetic material between different chromosomes or regions within the same chromosome in viruses?

Recombination

What kind of mutations do not change the protein encoded by a gene in a virus?

Silent mutations

In which type of viruses does recombination generally occur, mediated by homology?

ds DNA viruses

What is the classic mechanism of recombination?

The nucleic acid strands break, and parts of the genomes from two parents are joined.

What is the process called when two chromosomes (M and F) break and rejoin to produce two re-arranged chromosomes (C1 and C2)?

Recombination of incompletely linked genes

What is the characteristic of a recombinant virus with a stable genome?

It yields progeny that are genetically similar to itself upon replication.

For viruses with segmented genomes (RNA viruses), how is the formation of recombinants caused?

By reassortment of individual genome fragments rather than by an actual crossover event

What is the evolutionary advantage conferred by segmented genomes in viruses like influenza?

Different strains can shuffle/mix and combine genes to produce offspring with unique characteristics.

What is the process called when different strains of a virus with a segmented genome shuffle/mix and combine genes to produce offspring with unique characteristics?

Reassortment or viral sex

Explore how viruses undergo genetic change through processes like antigenic drift and shift. Learn about the mechanisms behind minor changes in DNA or RNA and how certain mutations can lead to evolutionary advantages like drug resistance.

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